Incidental Mutation 'IGL01517:Vmn1r35'
ID90422
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r35
Ensembl Gene ENSMUSG00000060699
Gene Namevomeronasal 1 receptor 35
SynonymsV1rc12
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL01517
Quality Score
Status
Chromosome6
Chromosomal Location66678070-66685906 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 66679450 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 79 (T79A)
Ref Sequence ENSEMBL: ENSMUSP00000154707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071414] [ENSMUST00000227346] [ENSMUST00000227354] [ENSMUST00000227749] [ENSMUST00000227961]
Predicted Effect probably benign
Transcript: ENSMUST00000071414
AA Change: T79A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000071362
Gene: ENSMUSG00000060699
AA Change: T79A

DomainStartEndE-ValueType
Pfam:V1R 28 293 1.2e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227346
Predicted Effect probably benign
Transcript: ENSMUST00000227354
AA Change: T79A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000227749
AA Change: T79A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000227961
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 A T 13: 104,390,192 probably benign Het
Arpc1b A G 5: 145,127,869 probably benign Het
Ccdc54 G A 16: 50,589,917 L329F possibly damaging Het
Cdc42bpg G A 19: 6,318,437 R1055H probably damaging Het
Cylc1 A G X: 111,119,030 T29A possibly damaging Het
Ddx50 T C 10: 62,647,132 T53A probably benign Het
Dmap1 G A 4: 117,676,009 R283C probably damaging Het
Extl3 A T 14: 65,076,707 L342H probably damaging Het
Gjb3 A C 4: 127,326,121 I206S probably damaging Het
Gphn T A 12: 78,376,374 I53K probably damaging Het
Gpr22 C T 12: 31,708,710 probably benign Het
Inpp5b T A 4: 124,782,436 C362S probably benign Het
Iqgap3 C A 3: 88,109,396 Q1062K probably benign Het
Kdm2a A G 19: 4,362,061 probably benign Het
Ltbp3 A G 19: 5,757,732 D1167G possibly damaging Het
Mpo A G 11: 87,795,821 N65D possibly damaging Het
Mrpl2 A G 17: 46,649,983 R268G probably damaging Het
Nfkbia C T 12: 55,490,645 A220T probably damaging Het
Nlrc3 T A 16: 3,947,487 I1091F probably damaging Het
Notch2 T A 3: 98,138,655 S1674R probably benign Het
Olfr298 T C 7: 86,489,557 probably benign Het
Olfr63 T A 17: 33,269,655 N310K probably benign Het
Pde8b A G 13: 95,100,887 probably null Het
Pla2r1 A G 2: 60,504,253 Y392H probably damaging Het
Plekhm1 A T 11: 103,394,783 N275K possibly damaging Het
Prdm16 T C 4: 154,328,425 H1041R probably damaging Het
Rapsn C A 2: 91,036,618 N88K probably damaging Het
Rasef T A 4: 73,769,822 Q31H probably benign Het
Rpl28-ps4 T C 6: 117,213,852 noncoding transcript Het
Trpc7 T C 13: 56,861,065 Y263C probably damaging Het
Ttn T C 2: 76,747,596 T24318A probably damaging Het
Vmn2r100 T A 17: 19,521,963 S200T probably benign Het
Wnt9b A G 11: 103,731,081 V250A probably benign Het
Zyg11a T A 4: 108,201,194 K383M probably null Het
Other mutations in Vmn1r35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00962:Vmn1r35 APN 6 66679377 missense possibly damaging 0.90
IGL01417:Vmn1r35 APN 6 66679207 missense probably benign 0.00
IGL02142:Vmn1r35 APN 6 66679350 missense probably damaging 1.00
IGL02178:Vmn1r35 APN 6 66679102 missense probably damaging 1.00
IGL02383:Vmn1r35 APN 6 66678891 missense probably damaging 1.00
IGL02383:Vmn1r35 APN 6 66678892 missense probably damaging 1.00
IGL02493:Vmn1r35 APN 6 66679479 missense possibly damaging 0.76
R0360:Vmn1r35 UTSW 6 66678843 missense probably damaging 0.99
R0364:Vmn1r35 UTSW 6 66678843 missense probably damaging 0.99
R0599:Vmn1r35 UTSW 6 66679513 missense probably benign 0.06
R1447:Vmn1r35 UTSW 6 66678906 missense probably benign 0.13
R1781:Vmn1r35 UTSW 6 66679566 missense probably benign 0.24
R2096:Vmn1r35 UTSW 6 66678945 missense possibly damaging 0.94
R2937:Vmn1r35 UTSW 6 66678966 missense possibly damaging 0.78
R2938:Vmn1r35 UTSW 6 66678966 missense possibly damaging 0.78
R3937:Vmn1r35 UTSW 6 66679073 missense probably damaging 1.00
R3938:Vmn1r35 UTSW 6 66679073 missense probably damaging 1.00
R4386:Vmn1r35 UTSW 6 66679589 nonsense probably null
R5329:Vmn1r35 UTSW 6 66679506 nonsense probably null
R6638:Vmn1r35 UTSW 6 66678864 missense possibly damaging 0.63
R7175:Vmn1r35 UTSW 6 66678922 missense probably benign 0.06
R7448:Vmn1r35 UTSW 6 66679235 start gained probably benign
R7825:Vmn1r35 UTSW 6 66679459 missense probably damaging 1.00
Posted On2013-12-09