Incidental Mutation 'IGL01517:Cylc1'
ID 90435
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cylc1
Ensembl Gene ENSMUSG00000073001
Gene Name cylicin, basic protein of sperm head cytoskeleton 1
Synonyms 4930401M13Rik
Accession Numbers
Essential gene? Not available question?
Stock # IGL01517
Quality Score
Status
Chromosome X
Chromosomal Location 110154024-110169624 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 110162799 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 29 (T29A)
Ref Sequence ENSEMBL: ENSMUSP00000147334 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101282] [ENSMUST00000210720]
AlphaFold A0A1B0GR13
Predicted Effect possibly damaging
Transcript: ENSMUST00000101282
AA Change: T29A

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000098840
Gene: ENSMUSG00000073001
AA Change: T29A

DomainStartEndE-ValueType
Pfam:Cylicin_N 26 131 2.8e-42 PFAM
low complexity region 307 330 N/A INTRINSIC
low complexity region 334 371 N/A INTRINSIC
low complexity region 376 398 N/A INTRINSIC
low complexity region 402 420 N/A INTRINSIC
low complexity region 421 450 N/A INTRINSIC
low complexity region 467 491 N/A INTRINSIC
low complexity region 513 523 N/A INTRINSIC
low complexity region 532 542 N/A INTRINSIC
low complexity region 549 562 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000210720
AA Change: T29A

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 A T 13: 104,526,700 (GRCm39) probably benign Het
Arpc1b A G 5: 145,064,679 (GRCm39) probably benign Het
Ccdc54 G A 16: 50,410,280 (GRCm39) L329F possibly damaging Het
Cdc42bpg G A 19: 6,368,467 (GRCm39) R1055H probably damaging Het
Ddx50 T C 10: 62,482,911 (GRCm39) T53A probably benign Het
Dmap1 G A 4: 117,533,206 (GRCm39) R283C probably damaging Het
Extl3 A T 14: 65,314,156 (GRCm39) L342H probably damaging Het
Gjb3 A C 4: 127,219,914 (GRCm39) I206S probably damaging Het
Gphn T A 12: 78,423,148 (GRCm39) I53K probably damaging Het
Gpr22 C T 12: 31,758,709 (GRCm39) probably benign Het
Inpp5b T A 4: 124,676,229 (GRCm39) C362S probably benign Het
Iqgap3 C A 3: 88,016,703 (GRCm39) Q1062K probably benign Het
Kdm2a A G 19: 4,412,089 (GRCm39) probably benign Het
Ltbp3 A G 19: 5,807,760 (GRCm39) D1167G possibly damaging Het
Mpo A G 11: 87,686,647 (GRCm39) N65D possibly damaging Het
Mrpl2 A G 17: 46,960,909 (GRCm39) R268G probably damaging Het
Nfkbia C T 12: 55,537,430 (GRCm39) A220T probably damaging Het
Nlrc3 T A 16: 3,765,351 (GRCm39) I1091F probably damaging Het
Notch2 T A 3: 98,045,971 (GRCm39) S1674R probably benign Het
Or10h28 T A 17: 33,488,629 (GRCm39) N310K probably benign Het
Or14a257 T C 7: 86,138,765 (GRCm39) probably benign Het
Pde8b A G 13: 95,237,395 (GRCm39) probably null Het
Pla2r1 A G 2: 60,334,597 (GRCm39) Y392H probably damaging Het
Plekhm1 A T 11: 103,285,609 (GRCm39) N275K possibly damaging Het
Prdm16 T C 4: 154,412,882 (GRCm39) H1041R probably damaging Het
Rapsn C A 2: 90,866,963 (GRCm39) N88K probably damaging Het
Rasef T A 4: 73,688,059 (GRCm39) Q31H probably benign Het
Rpl28-ps4 T C 6: 117,190,813 (GRCm39) noncoding transcript Het
Trpc7 T C 13: 57,008,878 (GRCm39) Y263C probably damaging Het
Ttn T C 2: 76,577,940 (GRCm39) T24318A probably damaging Het
Vmn1r35 T C 6: 66,656,434 (GRCm39) T79A probably benign Het
Vmn2r100 T A 17: 19,742,225 (GRCm39) S200T probably benign Het
Wnt9b A G 11: 103,621,907 (GRCm39) V250A probably benign Het
Zyg11a T A 4: 108,058,391 (GRCm39) K383M probably null Het
Other mutations in Cylc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01473:Cylc1 APN X 110,166,449 (GRCm39) missense unknown
IGL01656:Cylc1 APN X 110,167,485 (GRCm39) missense probably benign 0.35
IGL02944:Cylc1 APN X 110,167,373 (GRCm39) missense possibly damaging 0.91
IGL03029:Cylc1 APN X 110,156,944 (GRCm39) splice site probably benign
IGL03057:Cylc1 APN X 110,166,370 (GRCm39) missense unknown
R2060:Cylc1 UTSW X 110,166,892 (GRCm39) missense unknown
Z1176:Cylc1 UTSW X 110,166,915 (GRCm39) missense unknown
Z1177:Cylc1 UTSW X 110,166,048 (GRCm39) missense probably benign 0.03
Posted On 2013-12-09