Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01520:Vmn1r85'

90473

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r85

Ensembl Gene

ENSMUSG00000070817

Gene Name

vomeronasal 1 receptor 85

Synonyms

V1rj3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01520

Quality Score

Status

Chromosome

Chromosomal Location

12818216-12819142 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 12819081 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glycine at position 21 (V21G)

Ref Sequence

ENSEMBL: ENSMUSP00000148178 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094829] [ENSMUST00000209822]

AlphaFold

Q8VIB8

Predicted Effect

probably damaging
Transcript: ENSMUST00000094829
AA Change: V21G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000092424
Gene: ENSMUSG00000070817
AA Change: V21G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	296	8.4e-18	PFAM
Pfam:V1R	24	298	2.5e-36	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000209822
AA Change: V21G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	T	A	7: 78,734,318 (GRCm39)	H58Q	probably damaging	Het
Atp6v1c2	A	T	12: 17,347,754 (GRCm39)	L149Q	probably damaging	Het
Bltp1	T	A	3: 37,027,409 (GRCm39)	Y2265*	probably null	Het
Cd40lg	A	G	X: 56,265,148 (GRCm39)	N132D	probably benign	Het
Cemip	G	T	7: 83,597,830 (GRCm39)	T1060K	probably benign	Het
Ces1a	G	T	8: 93,771,726 (GRCm39)	P24T	probably damaging	Het
Ces5a	A	T	8: 94,246,206 (GRCm39)	S328T	probably benign	Het
Cfap70	A	G	14: 20,470,755 (GRCm39)	C497R	probably benign	Het
Cndp2	T	C	18: 84,686,732 (GRCm39)	K430R	probably benign	Het
Cplane1	C	A	15: 8,251,395 (GRCm39)	T1889K	probably damaging	Het
Crlf3	T	C	11: 79,950,972 (GRCm39)	D126G	probably benign	Het
Cxcr1	A	T	1: 74,231,434 (GRCm39)	L196Q	probably damaging	Het
E330013P04Rik	A	G	19: 60,150,329 (GRCm39)		noncoding transcript	Het
Erbb2	C	T	11: 98,324,835 (GRCm39)	H810Y	probably benign	Het
Fmn1	C	A	2: 113,274,713 (GRCm39)		probably benign	Het
Fpr3	A	G	17: 18,191,325 (GRCm39)	T199A	possibly damaging	Het
Gcsh	A	G	8: 117,710,688 (GRCm39)		probably benign	Het
Gm10073	T	A	8: 107,299,901 (GRCm39)	I28F	probably benign	Het
Gucy1a2	C	A	9: 3,759,561 (GRCm39)	Q456K	probably damaging	Het
Hgs	C	A	11: 120,369,174 (GRCm39)	P317T	probably damaging	Het
Inmt	C	A	6: 55,148,213 (GRCm39)	V139F	probably damaging	Het
Kcnma1	C	A	14: 23,551,211 (GRCm39)	M460I	possibly damaging	Het
Map9	A	T	3: 82,286,272 (GRCm39)	N359I	probably damaging	Het
Mavs	T	C	2: 131,087,263 (GRCm39)	S254P	probably benign	Het
Mcts1	T	A	X: 37,700,636 (GRCm39)		probably benign	Het
Mecp2	C	A	X: 73,079,447 (GRCm39)	R344L	possibly damaging	Het
Or1e32	T	G	11: 73,705,612 (GRCm39)	T99P	probably damaging	Het
Or4z4	A	G	19: 12,077,000 (GRCm39)	M1T	probably null	Het
Or5b3	G	T	19: 13,388,114 (GRCm39)	M60I	probably damaging	Het
Or8g36	T	C	9: 39,422,342 (GRCm39)	I225V	possibly damaging	Het
Or8g54	T	G	9: 39,706,674 (GRCm39)	M1R	probably null	Het
Or9g4	T	C	2: 85,504,701 (GRCm39)	T265A	probably benign	Het
Rasgrp1	T	C	2: 117,119,144 (GRCm39)	I498V	probably damaging	Het
Rbbp6	T	A	7: 122,584,898 (GRCm39)	S185T	possibly damaging	Het
Rd3	A	T	1: 191,717,283 (GRCm39)	H251L	possibly damaging	Het
Rnf180	T	A	13: 105,386,864 (GRCm39)	D148V	probably damaging	Het
Rnf43	C	A	11: 87,555,542 (GRCm39)	A34E	probably damaging	Het
Rslcan18	A	G	13: 67,250,172 (GRCm39)	V21A	probably benign	Het
Septin9	T	C	11: 117,243,469 (GRCm39)	V128A	probably damaging	Het
Slc36a1	A	G	11: 55,110,482 (GRCm39)	H103R	probably benign	Het
Spata6l	A	T	19: 28,873,532 (GRCm39)		probably null	Het
Ssh2	A	G	11: 77,340,732 (GRCm39)	D628G	probably damaging	Het
Tlcd3a	T	C	11: 76,098,051 (GRCm39)		probably null	Het
Tmem119	A	G	5: 113,933,546 (GRCm39)	F85S	probably damaging	Het
Tpp1	A	T	7: 105,396,936 (GRCm39)	I398N	probably benign	Het
Ttc3	T	C	16: 94,191,066 (GRCm39)	Y203H	probably benign	Het
Vars1	G	T	17: 35,232,849 (GRCm39)	V898L	probably benign	Het
Zfp521	T	C	18: 14,072,045 (GRCm39)	H65R	possibly damaging	Het

Other mutations in Vmn1r85

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01099:Vmn1r85	APN	7	12,818,461 (GRCm39)	nonsense	probably null
IGL01803:Vmn1r85	APN	7	12,818,496 (GRCm39)	missense	probably damaging	0.98
IGL02285:Vmn1r85	APN	7	12,818,711 (GRCm39)	missense	probably damaging	1.00
IGL02852:Vmn1r85	APN	7	12,819,010 (GRCm39)	missense	possibly damaging	0.70
IGL03012:Vmn1r85	APN	7	12,818,692 (GRCm39)	missense	probably benign	0.01
R0391:Vmn1r85	UTSW	7	12,818,515 (GRCm39)	missense	probably benign	0.01
R0655:Vmn1r85	UTSW	7	12,818,650 (GRCm39)	missense	probably damaging	1.00
R1142:Vmn1r85	UTSW	7	12,818,481 (GRCm39)	missense	probably benign	0.01
R1452:Vmn1r85	UTSW	7	12,818,808 (GRCm39)	missense	probably damaging	1.00
R1942:Vmn1r85	UTSW	7	12,818,668 (GRCm39)	missense	possibly damaging	0.83
R3760:Vmn1r85	UTSW	7	12,818,932 (GRCm39)	missense	probably damaging	0.96
R4783:Vmn1r85	UTSW	7	12,818,788 (GRCm39)	missense	probably damaging	1.00
R4785:Vmn1r85	UTSW	7	12,818,788 (GRCm39)	missense	probably damaging	1.00
R5373:Vmn1r85	UTSW	7	12,818,255 (GRCm39)	nonsense	probably null
R6021:Vmn1r85	UTSW	7	12,818,616 (GRCm39)	missense	probably benign	0.00
R6035:Vmn1r85	UTSW	7	12,818,854 (GRCm39)	missense	probably damaging	1.00
R6035:Vmn1r85	UTSW	7	12,818,854 (GRCm39)	missense	probably damaging	1.00
R6834:Vmn1r85	UTSW	7	12,818,571 (GRCm39)	missense	probably damaging	1.00
R7340:Vmn1r85	UTSW	7	12,819,073 (GRCm39)	missense	probably damaging	1.00
R7346:Vmn1r85	UTSW	7	12,818,964 (GRCm39)	missense	probably damaging	0.99
R7836:Vmn1r85	UTSW	7	12,818,698 (GRCm39)	missense	probably benign	0.06
R7896:Vmn1r85	UTSW	7	12,818,448 (GRCm39)	missense	probably benign	0.22
R9090:Vmn1r85	UTSW	7	12,818,942 (GRCm39)	nonsense	probably null
R9271:Vmn1r85	UTSW	7	12,818,942 (GRCm39)	nonsense	probably null
R9354:Vmn1r85	UTSW	7	12,818,725 (GRCm39)	missense	probably damaging	1.00
R9713:Vmn1r85	UTSW	7	12,818,458 (GRCm39)	missense	probably damaging	1.00
R9779:Vmn1r85	UTSW	7	12,818,308 (GRCm39)	missense	probably benign	0.02

Posted On

2013-12-09