Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01521:Bicra'

90519

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Bicra

Ensembl Gene

ENSMUSG00000070808

Gene Name

BRD4 interacting chromatin remodeling complex associated protein

Synonyms

Gltscr1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.212) question?

Stock #

IGL01521

Quality Score

Status

Chromosome

Chromosomal Location

15704597-15781846 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 15723113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 135 (Q135K)

Ref Sequence

ENSEMBL: ENSMUSP00000148012 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000210781]

AlphaFold

F8VPZ9

Predicted Effect

probably benign
Transcript: ENSMUST00000094821
AA Change: Q135K

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: Q135K

Domain	Start	End	E-Value	Type
low complexity region	86	96	N/A	INTRINSIC
low complexity region	140	155	N/A	INTRINSIC
internal_repeat_1	156	298	1.03e-6	PROSPERO
low complexity region	308	323	N/A	INTRINSIC
low complexity region	427	443	N/A	INTRINSIC
internal_repeat_1	479	614	1.03e-6	PROSPERO
low complexity region	619	638	N/A	INTRINSIC
low complexity region	642	676	N/A	INTRINSIC
low complexity region	719	732	N/A	INTRINSIC
low complexity region	756	782	N/A	INTRINSIC
low complexity region	790	819	N/A	INTRINSIC
low complexity region	827	843	N/A	INTRINSIC
low complexity region	852	906	N/A	INTRINSIC
low complexity region	940	950	N/A	INTRINSIC
low complexity region	987	1006	N/A	INTRINSIC
Pfam:GLTSCR1	1094	1202	4.6e-43	PFAM
low complexity region	1232	1251	N/A	INTRINSIC
low complexity region	1275	1294	N/A	INTRINSIC
low complexity region	1349	1371	N/A	INTRINSIC
low complexity region	1460	1473	N/A	INTRINSIC
low complexity region	1535	1555	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210035

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210713

Predicted Effect

probably benign
Transcript: ENSMUST00000210781
AA Change: Q135K

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars1	A	T	8: 111,770,419 (GRCm39)	I406F	possibly damaging	Het
Adgrb2	A	G	4: 129,886,085 (GRCm39)	E75G	probably damaging	Het
Angptl2	T	C	2: 33,136,215 (GRCm39)	Y467H	probably damaging	Het
Arap1	G	T	7: 101,049,812 (GRCm39)		probably null	Het
Arfgap1	G	A	2: 180,613,371 (GRCm39)	C22Y	probably damaging	Het
Artn	G	A	4: 117,784,484 (GRCm39)	P25S	probably damaging	Het
Clpx	T	C	9: 65,226,026 (GRCm39)	V367A	probably damaging	Het
Clstn3	C	T	6: 124,434,990 (GRCm39)	W308*	probably null	Het
Cpb2	T	A	14: 75,495,071 (GRCm39)	V67D	probably damaging	Het
Cyp2c38	A	G	19: 39,449,114 (GRCm39)	Y80H	probably damaging	Het
Dbt	A	G	3: 116,327,032 (GRCm39)	D127G	probably benign	Het
Elp1	T	A	4: 56,771,059 (GRCm39)	E961D	probably benign	Het
Fhod1	G	A	8: 106,057,055 (GRCm39)	A973V	probably benign	Het
Flacc1	T	G	1: 58,709,553 (GRCm39)	K201Q	probably damaging	Het
Focad	A	T	4: 88,328,927 (GRCm39)	*1713C	probably null	Het
Gemin5	A	T	11: 58,025,744 (GRCm39)		probably benign	Het
Gpr22	C	T	12: 31,758,709 (GRCm39)		probably benign	Het
Kif23	T	A	9: 61,827,182 (GRCm39)	T890S	probably damaging	Het
Kmt5b	T	A	19: 3,836,618 (GRCm39)	S52T	possibly damaging	Het
Lipo3	A	T	19: 33,763,083 (GRCm39)	D53E	probably damaging	Het
Lrrc14b	G	A	13: 74,511,691 (GRCm39)	R130C	probably damaging	Het
Myt1	T	A	2: 181,467,704 (GRCm39)	I1046K	probably damaging	Het
Napsa	A	T	7: 44,236,061 (GRCm39)	I367F	probably damaging	Het
Or5aq1b	C	T	2: 86,902,077 (GRCm39)	V134I	probably benign	Het
Or8b56	A	T	9: 38,739,185 (GRCm39)	Y66F	probably damaging	Het
Rgcc	T	G	14: 79,538,185 (GRCm39)	S69R	probably damaging	Het
Rin3	T	A	12: 102,335,307 (GRCm39)	I326N	probably benign	Het
Sipa1	C	A	19: 5,711,006 (GRCm39)	M1I	probably null	Het
Sirpb1a	T	A	3: 15,475,561 (GRCm39)	M325L	probably benign	Het
Sult1a1	C	A	7: 126,274,451 (GRCm39)	V71F	possibly damaging	Het
Tgds	G	T	14: 118,350,506 (GRCm39)	P349Q	probably damaging	Het
Tmem63c	T	A	12: 87,115,918 (GRCm39)	H186Q	probably damaging	Het
Trappc9	A	G	15: 72,924,016 (GRCm39)	L242S	probably damaging	Het
Trip12	T	A	1: 84,743,919 (GRCm39)		probably benign	Het
Zfp451	T	C	1: 33,816,412 (GRCm39)		probably null	Het

Other mutations in Bicra

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00909:Bicra	APN	7	15,730,502 (GRCm39)	missense	possibly damaging	0.70
IGL01690:Bicra	APN	7	15,721,678 (GRCm39)	missense	probably benign	0.09
IGL01721:Bicra	APN	7	15,722,624 (GRCm39)	missense	probably benign
IGL01994:Bicra	APN	7	15,706,741 (GRCm39)	missense	possibly damaging	0.46
IGL02084:Bicra	APN	7	15,721,663 (GRCm39)	missense	probably benign	0.09
IGL02312:Bicra	APN	7	15,727,066 (GRCm39)	missense	possibly damaging	0.85
IGL02686:Bicra	APN	7	15,721,840 (GRCm39)	missense	probably benign	0.02
IGL02727:Bicra	APN	7	15,713,390 (GRCm39)	missense	possibly damaging	0.95
IGL03031:Bicra	APN	7	15,709,726 (GRCm39)	missense	probably benign	0.16
R0003:Bicra	UTSW	7	15,705,812 (GRCm39)	missense	probably benign
R0025:Bicra	UTSW	7	15,721,436 (GRCm39)	missense	possibly damaging	0.53
R0241:Bicra	UTSW	7	15,709,070 (GRCm39)	missense	probably damaging	1.00
R0241:Bicra	UTSW	7	15,709,070 (GRCm39)	missense	probably damaging	1.00
R0417:Bicra	UTSW	7	15,706,247 (GRCm39)	missense	probably damaging	1.00
R0437:Bicra	UTSW	7	15,722,687 (GRCm39)	missense	possibly damaging	0.73
R0547:Bicra	UTSW	7	15,706,173 (GRCm39)	missense	probably damaging	1.00
R0688:Bicra	UTSW	7	15,723,247 (GRCm39)	missense	probably damaging	1.00
R0855:Bicra	UTSW	7	15,705,929 (GRCm39)	missense	probably damaging	1.00
R1448:Bicra	UTSW	7	15,722,284 (GRCm39)	missense	possibly damaging	0.86
R1637:Bicra	UTSW	7	15,706,614 (GRCm39)	missense	probably benign	0.19
R1899:Bicra	UTSW	7	15,721,676 (GRCm39)	missense	possibly damaging	0.53
R2035:Bicra	UTSW	7	15,730,338 (GRCm39)	missense	possibly damaging	0.53
R2247:Bicra	UTSW	7	15,723,159 (GRCm39)	missense	probably benign	0.33
R2471:Bicra	UTSW	7	15,706,257 (GRCm39)	missense	probably benign	0.04
R2484:Bicra	UTSW	7	15,722,605 (GRCm39)	missense	possibly damaging	0.96
R3437:Bicra	UTSW	7	15,723,223 (GRCm39)	missense	possibly damaging	0.85
R3551:Bicra	UTSW	7	15,713,658 (GRCm39)	missense	probably benign	0.33
R4816:Bicra	UTSW	7	15,722,831 (GRCm39)	missense	possibly damaging	0.53
R4901:Bicra	UTSW	7	15,721,526 (GRCm39)	missense	possibly damaging	0.53
R5035:Bicra	UTSW	7	15,713,349 (GRCm39)	missense	possibly damaging	0.90
R5078:Bicra	UTSW	7	15,709,382 (GRCm39)	missense	probably damaging	1.00
R5094:Bicra	UTSW	7	15,709,296 (GRCm39)	missense	probably damaging	1.00
R5195:Bicra	UTSW	7	15,713,878 (GRCm39)	missense	possibly damaging	0.93
R5496:Bicra	UTSW	7	15,721,766 (GRCm39)	missense	probably benign	0.33
R5780:Bicra	UTSW	7	15,713,679 (GRCm39)	missense	possibly damaging	0.96
R6541:Bicra	UTSW	7	15,713,054 (GRCm39)	missense	probably benign	0.00
R6560:Bicra	UTSW	7	15,723,119 (GRCm39)	missense	possibly damaging	0.53
R6575:Bicra	UTSW	7	15,713,056 (GRCm39)	missense	probably benign	0.25
R6854:Bicra	UTSW	7	15,722,687 (GRCm39)	missense	probably benign	0.18
R6967:Bicra	UTSW	7	15,706,130 (GRCm39)	missense	probably damaging	0.97
R7283:Bicra	UTSW	7	15,706,425 (GRCm39)	missense	probably damaging	1.00
R7454:Bicra	UTSW	7	15,706,059 (GRCm39)	missense	probably benign	0.30
R7462:Bicra	UTSW	7	15,713,060 (GRCm39)	missense	possibly damaging	0.84
R7488:Bicra	UTSW	7	15,723,367 (GRCm39)	critical splice acceptor site	probably null
R7506:Bicra	UTSW	7	15,722,138 (GRCm39)	missense	possibly damaging	0.96
R7534:Bicra	UTSW	7	15,705,860 (GRCm39)	missense	probably damaging	0.98
R7915:Bicra	UTSW	7	15,722,447 (GRCm39)	missense	probably benign
R8063:Bicra	UTSW	7	15,712,969 (GRCm39)	missense	probably benign
R8147:Bicra	UTSW	7	15,722,395 (GRCm39)	missense	possibly damaging	0.93
R8699:Bicra	UTSW	7	15,723,113 (GRCm39)	missense	probably benign	0.18
R8784:Bicra	UTSW	7	15,705,875 (GRCm39)	missense	probably damaging	1.00
R8859:Bicra	UTSW	7	15,721,737 (GRCm39)	missense	possibly damaging	0.73
R8971:Bicra	UTSW	7	15,721,481 (GRCm39)	missense	probably benign	0.08
R9487:Bicra	UTSW	7	15,705,717 (GRCm39)	missense	probably damaging	0.99
R9614:Bicra	UTSW	7	15,705,880 (GRCm39)	missense	probably damaging	1.00
R9721:Bicra	UTSW	7	15,713,101 (GRCm39)	missense	probably damaging	1.00
R9777:Bicra	UTSW	7	15,705,987 (GRCm39)	missense	probably benign	0.09
X0064:Bicra	UTSW	7	15,709,700 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09