Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01552:Zfp827'

90611

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp827

Ensembl Gene

ENSMUSG00000071064

Gene Name

zinc finger protein 827

Synonyms

2810449M09Rik, D630040G17Rik

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.902) question?

Stock #

IGL01552

Quality Score

Status

Chromosome

Chromosomal Location

79028437-79193766 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79076191 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 464 (E464G)

Ref Sequence

ENSEMBL: ENSMUSP00000113199 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087927] [ENSMUST00000098614] [ENSMUST00000119254]

Predicted Effect

probably benign
Transcript: ENSMUST00000087927

SMART Domains

Protein: ENSMUSP00000085238
Gene: ENSMUSG00000071064

Domain	Start	End	E-Value	Type
low complexity region	102	128	N/A	INTRINSIC
low complexity region	226	256	N/A	INTRINSIC
low complexity region	271	298	N/A	INTRINSIC
low complexity region	306	342	N/A	INTRINSIC
low complexity region	343	348	N/A	INTRINSIC
ZnF_C2H2	371	393	6.78e-3	SMART
ZnF_C2H2	399	422	5.59e-4	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000098614
AA Change: E464G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000096214
Gene: ENSMUSG00000071064
AA Change: E464G

Domain	Start	End	E-Value	Type
low complexity region	102	128	N/A	INTRINSIC
low complexity region	226	256	N/A	INTRINSIC
low complexity region	271	298	N/A	INTRINSIC
low complexity region	306	342	N/A	INTRINSIC
low complexity region	343	348	N/A	INTRINSIC
ZnF_C2H2	371	393	6.78e-3	SMART
ZnF_C2H2	399	421	2.99e-4	SMART
ZnF_C2H2	430	452	5.42e-2	SMART
internal_repeat_2	561	585	3.31e-7	PROSPERO
low complexity region	613	627	N/A	INTRINSIC
internal_repeat_2	719	743	3.31e-7	PROSPERO
ZnF_C2H2	814	836	2.4e-3	SMART
ZnF_C2H2	842	864	4.72e-2	SMART
ZnF_C2H2	894	916	1.64e-1	SMART
ZnF_C2H2	926	949	7.89e0	SMART
low complexity region	956	974	N/A	INTRINSIC
ZnF_C2H2	1016	1038	1.26e-2	SMART
ZnF_C2H2	1044	1066	3.07e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000119254
AA Change: E464G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000113199
Gene: ENSMUSG00000071064
AA Change: E464G

Domain	Start	End	E-Value	Type
low complexity region	102	128	N/A	INTRINSIC
low complexity region	226	256	N/A	INTRINSIC
low complexity region	271	298	N/A	INTRINSIC
low complexity region	306	342	N/A	INTRINSIC
low complexity region	343	348	N/A	INTRINSIC
ZnF_C2H2	371	393	6.78e-3	SMART
ZnF_C2H2	399	421	2.99e-4	SMART
ZnF_C2H2	430	452	5.42e-2	SMART
internal_repeat_2	561	585	3.25e-7	PROSPERO
low complexity region	613	627	N/A	INTRINSIC
internal_repeat_2	719	743	3.25e-7	PROSPERO
ZnF_C2H2	814	836	2.4e-3	SMART
ZnF_C2H2	842	864	4.72e-2	SMART
ZnF_C2H2	894	916	1.64e-1	SMART
ZnF_C2H2	926	949	7.89e0	SMART
low complexity region	956	974	N/A	INTRINSIC
ZnF_C2H2	1016	1038	1.26e-2	SMART
ZnF_C2H2	1044	1066	3.07e-1	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417C22Rik	A	G	3: 108,481,312	W252R	possibly damaging	Het
Arl8a	T	C	1: 135,152,868		probably null	Het
Bivm	A	G	1: 44,126,773	N128D	probably benign	Het
Chil3	C	A	3: 106,148,848	G330V	probably damaging	Het
Dscaml1	A	G	9: 45,447,908	H155R	probably damaging	Het
Etl4	T	A	2: 20,778,189	V687D	probably damaging	Het
Fbxw10	A	T	11: 62,857,684		probably null	Het
Gfpt2	G	T	11: 49,805,005	E21*	probably null	Het
Gm10197	C	T	19: 53,371,691	V26I	possibly damaging	Het
Gm4788	A	G	1: 139,739,302	Y412H	probably damaging	Het
Gm6614	T	C	6: 141,987,706	K451R	possibly damaging	Het
Golim4	T	C	3: 75,956,195	E35G	probably damaging	Het
Igdcc4	A	G	9: 65,122,502		probably benign	Het
Ino80d	A	G	1: 63,057,977		probably benign	Het
Ipo13	A	G	4: 117,900,964	M734T	probably benign	Het
Klk1b27	C	T	7: 44,054,615	L61F	probably damaging	Het
Lamtor5	T	C	3: 107,279,008	V31A	probably benign	Het
Lrp1	A	T	10: 127,588,510	L769*	probably null	Het
Nipsnap1	A	T	11: 4,889,124	S135C	probably damaging	Het
Olfr1277	C	A	2: 111,269,912	G152C	probably damaging	Het
Pparg	A	T	6: 115,490,122	H452L	probably benign	Het
Rab34	C	T	11: 78,191,438	A202V	probably damaging	Het
Ryr3	T	A	2: 112,825,883	T1923S	possibly damaging	Het
Sall4	A	G	2: 168,756,123	S266P	probably damaging	Het
Sh2d4b	T	C	14: 40,860,648	Q195R	probably benign	Het
Sik2	C	A	9: 50,917,522		probably benign	Het
Slc25a36	A	G	9: 97,079,233	V111A	probably benign	Het
Sptbn5	A	T	2: 120,054,422		probably benign	Het
Tac2	G	A	10: 127,726,101	E25K	possibly damaging	Het
Tnc	A	G	4: 63,970,408	V1807A	probably damaging	Het
Top3b	T	C	16: 16,887,823		probably benign	Het

Other mutations in Zfp827

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01448:Zfp827	APN	8	79060733	missense	possibly damaging	0.82
IGL01545:Zfp827	APN	8	79070434	missense	probably damaging	1.00
IGL02261:Zfp827	APN	8	79180079	missense	probably damaging	0.97
IGL02451:Zfp827	APN	8	79060972	missense	probably damaging	1.00
IGL03130:Zfp827	APN	8	79060957	missense	probably damaging	1.00
IGL03411:Zfp827	APN	8	79076487	missense	probably damaging	0.99
E0354:Zfp827	UTSW	8	79136577	missense	probably damaging	1.00
R0502:Zfp827	UTSW	8	79179077	splice site	probably null
R0547:Zfp827	UTSW	8	79060310	missense	probably damaging	1.00
R0926:Zfp827	UTSW	8	79118192	missense	probably benign	0.00
R0975:Zfp827	UTSW	8	79061185	missense	probably benign	0.00
R1305:Zfp827	UTSW	8	79060894	missense	possibly damaging	0.95
R1462:Zfp827	UTSW	8	79076479	missense	probably benign
R1462:Zfp827	UTSW	8	79076479	missense	probably benign
R1638:Zfp827	UTSW	8	79076346	missense	possibly damaging	0.94
R1714:Zfp827	UTSW	8	79060573	missense	probably damaging	1.00
R2044:Zfp827	UTSW	8	79076236	missense	probably benign
R2132:Zfp827	UTSW	8	79185721	missense	possibly damaging	0.53
R3844:Zfp827	UTSW	8	79136619	missense	probably damaging	0.99
R4329:Zfp827	UTSW	8	79189834	utr 3 prime	probably benign
R4629:Zfp827	UTSW	8	79060382	missense	probably damaging	0.99
R4873:Zfp827	UTSW	8	79060774	missense	probably damaging	1.00
R4875:Zfp827	UTSW	8	79060774	missense	probably damaging	1.00
R4936:Zfp827	UTSW	8	79061183	missense	probably benign
R4965:Zfp827	UTSW	8	79061281	missense	probably benign
R5103:Zfp827	UTSW	8	79070403	missense	probably damaging	1.00
R5366:Zfp827	UTSW	8	79185704	missense	possibly damaging	0.94
R5794:Zfp827	UTSW	8	79070442	missense	probably damaging	1.00
R5825:Zfp827	UTSW	8	79179016	missense	probably damaging	1.00
R6118:Zfp827	UTSW	8	79076438	missense	possibly damaging	0.75
R6236:Zfp827	UTSW	8	79070476	missense	probably damaging	1.00
R6263:Zfp827	UTSW	8	79179073	missense	probably damaging	1.00
R6306:Zfp827	UTSW	8	79060695	missense	probably damaging	1.00
R6490:Zfp827	UTSW	8	79189977	utr 3 prime	probably benign
R6497:Zfp827	UTSW	8	79180128	missense	probably damaging	1.00
R7250:Zfp827	UTSW	8	79190092	missense
R7290:Zfp827	UTSW	8	79189813	missense	possibly damaging	0.86
R7443:Zfp827	UTSW	8	79190418	missense
R7708:Zfp827	UTSW	8	79175962	missense	probably damaging	1.00
R7754:Zfp827	UTSW	8	79190329	missense
R7836:Zfp827	UTSW	8	79186350	missense	probably damaging	1.00
R7995:Zfp827	UTSW	8	79118258	missense	possibly damaging	0.86
R8162:Zfp827	UTSW	8	79060577	nonsense	probably null

Posted On

2013-12-09