Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01552:Igdcc4'

90622

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igdcc4

Ensembl Gene

ENSMUSG00000032816

Gene Name

immunoglobulin superfamily, DCC subclass, member 4

Synonyms

WI-18508, WI-16786, Nope, 9330155G14Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.248) question?

Stock #

IGL01552

Quality Score

Status

Chromosome

Chromosomal Location

65101486-65137940 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 65122502 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150272 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035499] [ENSMUST00000077696] [ENSMUST00000166273] [ENSMUST00000213533]

Predicted Effect

probably benign
Transcript: ENSMUST00000035499

SMART Domains

Protein: ENSMUSP00000045387
Gene: ENSMUSG00000032816

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	40	139	5e0	SMART
IGc2	154	218	1.3e-11	SMART
IGc2	255	318	1.13e-11	SMART
low complexity region	322	335	N/A	INTRINSIC
IGc2	346	411	1.34e-13	SMART
FN3	428	511	3.58e-12	SMART
FN3	526	610	9.54e-8	SMART
FN3	630	726	7.34e-9	SMART
FN3	750	832	1.05e-9	SMART
FN3	848	932	2.14e-10	SMART
low complexity region	958	978	N/A	INTRINSIC
low complexity region	1085	1100	N/A	INTRINSIC
low complexity region	1154	1168	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000077696

SMART Domains

Protein: ENSMUSP00000076878
Gene: ENSMUSG00000032816

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	40	139	5e0	SMART
IGc2	154	218	1.3e-11	SMART
IGc2	255	458	7.02e-8	SMART
FN3	475	558	3.58e-12	SMART
FN3	573	656	1.1e-7	SMART
FN3	676	772	7.34e-9	SMART
FN3	796	878	1.05e-9	SMART
FN3	894	978	2.14e-10	SMART
low complexity region	1004	1024	N/A	INTRINSIC
low complexity region	1131	1146	N/A	INTRINSIC
low complexity region	1200	1214	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000166273

SMART Domains

Protein: ENSMUSP00000132576
Gene: ENSMUSG00000032816

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Blast:IG	40	83	3e-22	BLAST
low complexity region	142	156	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213423

Predicted Effect

probably benign
Transcript: ENSMUST00000213533

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214978

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216542

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417C22Rik	A	G	3: 108,481,312	W252R	possibly damaging	Het
Arl8a	T	C	1: 135,152,868		probably null	Het
Bivm	A	G	1: 44,126,773	N128D	probably benign	Het
Chil3	C	A	3: 106,148,848	G330V	probably damaging	Het
Dscaml1	A	G	9: 45,447,908	H155R	probably damaging	Het
Etl4	T	A	2: 20,778,189	V687D	probably damaging	Het
Fbxw10	A	T	11: 62,857,684		probably null	Het
Gfpt2	G	T	11: 49,805,005	E21*	probably null	Het
Gm10197	C	T	19: 53,371,691	V26I	possibly damaging	Het
Gm4788	A	G	1: 139,739,302	Y412H	probably damaging	Het
Gm6614	T	C	6: 141,987,706	K451R	possibly damaging	Het
Golim4	T	C	3: 75,956,195	E35G	probably damaging	Het
Ino80d	A	G	1: 63,057,977		probably benign	Het
Ipo13	A	G	4: 117,900,964	M734T	probably benign	Het
Klk1b27	C	T	7: 44,054,615	L61F	probably damaging	Het
Lamtor5	T	C	3: 107,279,008	V31A	probably benign	Het
Lrp1	A	T	10: 127,588,510	L769*	probably null	Het
Nipsnap1	A	T	11: 4,889,124	S135C	probably damaging	Het
Olfr1277	C	A	2: 111,269,912	G152C	probably damaging	Het
Pparg	A	T	6: 115,490,122	H452L	probably benign	Het
Rab34	C	T	11: 78,191,438	A202V	probably damaging	Het
Ryr3	T	A	2: 112,825,883	T1923S	possibly damaging	Het
Sall4	A	G	2: 168,756,123	S266P	probably damaging	Het
Sh2d4b	T	C	14: 40,860,648	Q195R	probably benign	Het
Sik2	C	A	9: 50,917,522		probably benign	Het
Slc25a36	A	G	9: 97,079,233	V111A	probably benign	Het
Sptbn5	A	T	2: 120,054,422		probably benign	Het
Tac2	G	A	10: 127,726,101	E25K	possibly damaging	Het
Tnc	A	G	4: 63,970,408	V1807A	probably damaging	Het
Top3b	T	C	16: 16,887,823		probably benign	Het
Zfp827	A	G	8: 79,076,191	E464G	probably damaging	Het

Other mutations in Igdcc4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01152:Igdcc4	APN	9	65135164	missense	probably damaging	1.00
IGL01285:Igdcc4	APN	9	65123991	missense	probably damaging	1.00
IGL01412:Igdcc4	APN	9	65114449	splice site	probably benign
IGL01485:Igdcc4	APN	9	65122607	missense	probably benign	0.02
IGL01651:Igdcc4	APN	9	65124112	missense	possibly damaging	0.63
IGL01751:Igdcc4	APN	9	65131732	missense	probably damaging	1.00
IGL02164:Igdcc4	APN	9	65124782	splice site	probably benign
IGL02468:Igdcc4	APN	9	65126832	missense	probably damaging	1.00
IGL02616:Igdcc4	APN	9	65133078	missense	probably damaging	1.00
IGL02685:Igdcc4	APN	9	65133825	missense	possibly damaging	0.81
IGL02734:Igdcc4	APN	9	65131456	missense	possibly damaging	0.47
IGL02893:Igdcc4	APN	9	65133071	missense	probably damaging	1.00
R0006:Igdcc4	UTSW	9	65135100	splice site	probably benign
R0583:Igdcc4	UTSW	9	65121813	missense	possibly damaging	0.85
R0939:Igdcc4	UTSW	9	65131473	critical splice donor site	probably null
R1075:Igdcc4	UTSW	9	65131650	missense	possibly damaging	0.90
R1110:Igdcc4	UTSW	9	65126926	missense	possibly damaging	0.91
R1183:Igdcc4	UTSW	9	65121900	missense	possibly damaging	0.91
R1318:Igdcc4	UTSW	9	65133690	missense	probably damaging	1.00
R1507:Igdcc4	UTSW	9	65133744	missense	probably damaging	1.00
R1548:Igdcc4	UTSW	9	65135227	missense	probably benign	0.08
R1640:Igdcc4	UTSW	9	65122795	missense	probably damaging	1.00
R1681:Igdcc4	UTSW	9	65128795	missense	probably damaging	1.00
R1687:Igdcc4	UTSW	9	65131663	missense	probably damaging	1.00
R1716:Igdcc4	UTSW	9	65126897	missense	probably damaging	1.00
R1964:Igdcc4	UTSW	9	65122769	missense	probably benign
R1996:Igdcc4	UTSW	9	65121819	missense	probably damaging	1.00
R2150:Igdcc4	UTSW	9	65125335	missense	possibly damaging	0.92
R2278:Igdcc4	UTSW	9	65130743	missense	probably damaging	1.00
R3085:Igdcc4	UTSW	9	65132058	missense	probably damaging	1.00
R4011:Igdcc4	UTSW	9	65135479	missense	probably benign
R4077:Igdcc4	UTSW	9	65131765	missense	probably damaging	1.00
R4191:Igdcc4	UTSW	9	65124151	missense	probably benign	0.13
R4293:Igdcc4	UTSW	9	65124610	critical splice acceptor site	probably null
R4589:Igdcc4	UTSW	9	65130628	missense	probably damaging	1.00
R4931:Igdcc4	UTSW	9	65124015	missense	possibly damaging	0.66
R5093:Igdcc4	UTSW	9	65122757	missense	possibly damaging	0.51
R5106:Igdcc4	UTSW	9	65124701	missense	probably damaging	1.00
R5546:Igdcc4	UTSW	9	65128795	missense	probably damaging	1.00
R5634:Igdcc4	UTSW	9	65134546	missense	probably benign	0.18
R5810:Igdcc4	UTSW	9	65128695	missense	probably damaging	1.00
R6395:Igdcc4	UTSW	9	65135118	missense	probably damaging	1.00
R6475:Igdcc4	UTSW	9	65120321	missense	probably damaging	1.00
R6776:Igdcc4	UTSW	9	65135418	missense	probably benign	0.02
R6828:Igdcc4	UTSW	9	65122697	missense	probably benign
R6914:Igdcc4	UTSW	9	65120268	missense	probably benign	0.00
R6942:Igdcc4	UTSW	9	65120268	missense	probably benign	0.00
R7072:Igdcc4	UTSW	9	65130731	missense	probably damaging	1.00
R7234:Igdcc4	UTSW	9	65135468	nonsense	probably null
R7448:Igdcc4	UTSW	9	65123994	missense	possibly damaging	0.52
R7562:Igdcc4	UTSW	9	65124024	missense	probably damaging	1.00
R7607:Igdcc4	UTSW	9	65133758	missense	possibly damaging	0.85
R7734:Igdcc4	UTSW	9	65131753	missense	probably damaging	0.99
R7807:Igdcc4	UTSW	9	65133795	missense	probably benign	0.00
R7852:Igdcc4	UTSW	9	65120258	missense	probably benign	0.04
R7904:Igdcc4	UTSW	9	65134519	missense	probably benign	0.00
R8133:Igdcc4	UTSW	9	65131741	missense	possibly damaging	0.54
R8147:Igdcc4	UTSW	9	65123971	missense	probably benign	0.42
R8230:Igdcc4	UTSW	9	65122738	missense	probably damaging	1.00

Posted On

2013-12-09