Incidental Mutation 'IGL01558:Sult2a8'
| ID |
90774 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Sult2a8
|
| Ensembl Gene |
ENSMUSG00000030378 |
| Gene Name |
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8 |
| Synonyms |
2810007J24Rik, mL-STL |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
IGL01558
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
14144611-14180694 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 14159377 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Stop codon
at position 81
(E81*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148036
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063509]
[ENSMUST00000125941]
[ENSMUST00000168252]
[ENSMUST00000209425]
[ENSMUST00000209972]
[ENSMUST00000210396]
[ENSMUST00000211800]
|
| AlphaFold |
Q8BGL3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000063509
AA Change: E81*
|
| SMART Domains |
Protein: ENSMUSP00000066897
Gene: ENSMUSG00000030378
AA Change: E81*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Sulfotransfer_1
|
34 |
275 |
1.6e-73 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000125941
AA Change: E81*
|
| SMART Domains |
Protein: ENSMUSP00000116469
Gene: ENSMUSG00000030378
AA Change: E81*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Sulfotransfer_1
|
34 |
189 |
4e-47 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000168252
AA Change: E81*
|
| SMART Domains |
Protein: ENSMUSP00000128428
Gene: ENSMUSG00000030378
AA Change: E81*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Sulfotransfer_1
|
34 |
275 |
1.6e-73 |
PFAM |
|
Pfam:Sulfotransfer_3
|
36 |
205 |
6.3e-10 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000209425
AA Change: E81*
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209972
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210366
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000210396
AA Change: E81*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000211800
AA Change: E81*
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aasdh |
T |
C |
5: 77,036,464 (GRCm39) |
E359G |
possibly damaging |
Het |
| Agtr1b |
T |
C |
3: 20,370,424 (GRCm39) |
T61A |
probably damaging |
Het |
| Casd1 |
T |
A |
6: 4,624,143 (GRCm39) |
I312N |
possibly damaging |
Het |
| Cebpz |
A |
T |
17: 79,242,734 (GRCm39) |
F307I |
probably damaging |
Het |
| Dhx33 |
T |
C |
11: 70,890,579 (GRCm39) |
R207G |
probably benign |
Het |
| G0s2 |
T |
C |
1: 192,955,003 (GRCm39) |
Y27C |
probably damaging |
Het |
| Glg1 |
A |
T |
8: 111,914,362 (GRCm39) |
M474K |
probably benign |
Het |
| Macf1 |
T |
C |
4: 123,346,798 (GRCm39) |
N2490S |
probably benign |
Het |
| Mpdz |
C |
A |
4: 81,213,767 (GRCm39) |
E1565* |
probably null |
Het |
| Mthfsl |
A |
G |
9: 88,570,870 (GRCm39) |
I126T |
possibly damaging |
Het |
| Nectin4 |
A |
G |
1: 171,212,257 (GRCm39) |
D285G |
probably benign |
Het |
| Neurod1 |
T |
C |
2: 79,284,363 (GRCm39) |
H340R |
possibly damaging |
Het |
| Nop53 |
G |
A |
7: 15,679,751 (GRCm39) |
|
probably benign |
Het |
| Siglec1 |
A |
G |
2: 130,920,419 (GRCm39) |
L795P |
probably damaging |
Het |
| Sntg1 |
A |
T |
1: 8,533,612 (GRCm39) |
|
probably benign |
Het |
| Stk33 |
T |
C |
7: 108,940,491 (GRCm39) |
|
probably benign |
Het |
| Stox1 |
C |
T |
10: 62,503,651 (GRCm39) |
V135M |
probably damaging |
Het |
| Tdrd6 |
A |
G |
17: 43,936,659 (GRCm39) |
V1463A |
probably damaging |
Het |
| Tdrd6 |
C |
T |
17: 43,935,657 (GRCm39) |
G1797D |
probably benign |
Het |
| Trmt2b |
C |
A |
X: 133,139,305 (GRCm39) |
R389I |
possibly damaging |
Het |
| Ttc28 |
G |
T |
5: 111,431,828 (GRCm39) |
V1903L |
probably damaging |
Het |
|
| Other mutations in Sult2a8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01904:Sult2a8
|
APN |
7 |
14,159,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02060:Sult2a8
|
APN |
7 |
14,159,326 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02532:Sult2a8
|
APN |
7 |
14,150,183 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02663:Sult2a8
|
APN |
7 |
14,159,368 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02803:Sult2a8
|
APN |
7 |
14,145,630 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1070:Sult2a8
|
UTSW |
7 |
14,147,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1251:Sult2a8
|
UTSW |
7 |
14,159,350 (GRCm39) |
nonsense |
probably null |
|
|
R1465:Sult2a8
|
UTSW |
7 |
14,150,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1465:Sult2a8
|
UTSW |
7 |
14,150,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1799:Sult2a8
|
UTSW |
7 |
14,157,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2196:Sult2a8
|
UTSW |
7 |
14,161,778 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4233:Sult2a8
|
UTSW |
7 |
14,147,608 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4713:Sult2a8
|
UTSW |
7 |
14,159,402 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4964:Sult2a8
|
UTSW |
7 |
14,159,457 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5114:Sult2a8
|
UTSW |
7 |
14,147,584 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5330:Sult2a8
|
UTSW |
7 |
14,147,679 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5439:Sult2a8
|
UTSW |
7 |
14,159,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5662:Sult2a8
|
UTSW |
7 |
14,161,765 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7353:Sult2a8
|
UTSW |
7 |
14,147,640 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7366:Sult2a8
|
UTSW |
7 |
14,150,254 (GRCm39) |
splice site |
probably null |
|
|
R7832:Sult2a8
|
UTSW |
7 |
14,147,596 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9499:Sult2a8
|
UTSW |
7 |
14,157,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation