Incidental Mutation 'IGL01559:Gm10642'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10642
Ensembl Gene ENSMUSG00000074213
Gene Namepredicted gene 10642
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01559
Quality Score
Chromosomal Location70656251-70657860 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 70656592 bp
Amino Acid Change Aspartic acid to Valine at position 152 (D152V)
Ref Sequence ENSEMBL: ENSMUSP00000150300 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049031] [ENSMUST00000098589] [ENSMUST00000213380]
Predicted Effect probably damaging
Transcript: ENSMUST00000049031
AA Change: D152V

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000037035
Gene: ENSMUSG00000042444
AA Change: D152V

low complexity region 22 41 N/A INTRINSIC
low complexity region 79 86 N/A INTRINSIC
low complexity region 126 173 N/A INTRINSIC
low complexity region 186 195 N/A INTRINSIC
Pfam:DUF544 250 373 6.9e-42 PFAM
low complexity region 498 508 N/A INTRINSIC
low complexity region 535 570 N/A INTRINSIC
low complexity region 578 595 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000098589
AA Change: V10D
SMART Domains Protein: ENSMUSP00000096188
Gene: ENSMUSG00000074213
AA Change: V10D

low complexity region 12 39 N/A INTRINSIC
low complexity region 55 67 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000213380
AA Change: D152V

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214293
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,309,020 N2915K possibly damaging Het
Abca5 T C 11: 110,272,526 N1621S probably benign Het
Asb18 G A 1: 89,954,450 S122F probably damaging Het
Atg4c A G 4: 99,218,203 probably benign Het
Bbs7 T C 3: 36,594,510 Y363C probably damaging Het
Celsr2 T C 3: 108,406,867 T1281A possibly damaging Het
Cers1 A G 8: 70,323,233 N295S probably damaging Het
Csn1s2b A T 5: 87,820,951 K80* probably null Het
Dennd6a A G 14: 26,608,565 D97G probably damaging Het
Dmxl1 A G 18: 49,920,938 Y2537C probably damaging Het
Dnah6 A G 6: 73,024,252 probably null Het
Exoc4 A G 6: 33,266,076 T75A probably damaging Het
Fbll1 T C 11: 35,797,545 E297G probably damaging Het
Hdac3 A G 18: 37,943,672 probably benign Het
Kif17 A G 4: 138,293,769 I850V probably damaging Het
Olfr166 T C 16: 19,487,459 L207P probably benign Het
Pi4kb T A 3: 94,984,129 L52Q probably benign Het
Sec14l1 C A 11: 117,143,284 probably null Het
Slc28a2 T A 2: 122,454,540 H336Q probably damaging Het
Usp17lb A G 7: 104,841,229 S164P probably damaging Het
Posted On2013-12-09