Incidental Mutation 'IGL01560:Olfr414'
ID90813
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr414
Ensembl Gene ENSMUSG00000051509
Gene Nameolfactory receptor 414
SynonymsGA_x6K02T2P20D-20749615-20748662, MOR103-10
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #IGL01560
Quality Score
Status
Chromosome1
Chromosomal Location174424064-174434747 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 174430901 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 158 (M158L)
Ref Sequence ENSEMBL: ENSMUSP00000142051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053178] [ENSMUST00000192358]
Predicted Effect probably benign
Transcript: ENSMUST00000053178
AA Change: M158L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000052426
Gene: ENSMUSG00000051509
AA Change: M158L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.8e-53 PFAM
Pfam:7tm_1 41 290 8.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000192358
AA Change: M158L

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000142051
Gene: ENSMUSG00000051509
AA Change: M158L

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 2.9e-29 PFAM
Pfam:7tm_4 139 283 1.1e-45 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931440F15Rik A T 11: 29,824,643 Y271* probably null Het
Arhgap28 A T 17: 67,896,071 I129N probably damaging Het
Arsb A G 13: 93,807,598 I266V probably benign Het
Atp6v1b1 A G 6: 83,749,915 probably benign Het
Cacna1d C T 14: 30,099,206 V1118I probably benign Het
Cadps A T 14: 12,491,792 V791D probably damaging Het
Cdh2 T C 18: 16,650,438 D78G probably benign Het
Flnb T G 14: 7,893,829 I714S probably benign Het
Fzd1 A G 5: 4,756,037 M515T probably benign Het
Lrpprc A T 17: 84,708,119 F1288Y probably benign Het
Lrrk2 A G 15: 91,774,988 I1868V probably benign Het
Mmel1 A G 4: 154,892,510 D561G probably null Het
Mypn A T 10: 63,134,964 V887E probably benign Het
Olfr1223 C T 2: 89,144,603 C140Y probably damaging Het
Olfr846 T C 9: 19,360,546 T270A probably benign Het
Osbpl5 C A 7: 143,715,693 E49* probably null Het
Prpf8 A G 11: 75,490,406 Q189R possibly damaging Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Six6 T A 12: 72,940,057 M1K probably null Het
Slc13a4 A G 6: 35,271,603 probably benign Het
Slc17a1 T A 13: 23,874,629 I22N probably damaging Het
Thsd7b C T 1: 130,218,181 probably benign Het
Thumpd3 A G 6: 113,063,159 I335V possibly damaging Het
Ttn T C 2: 76,771,672 T18549A possibly damaging Het
Ugt2b37 G T 5: 87,251,839 P270Q probably damaging Het
Wdfy3 A T 5: 101,957,486 Y158* probably null Het
Zfp282 A T 6: 47,880,277 E148V probably damaging Het
Other mutations in Olfr414
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Olfr414 APN 1 174431342 missense probably benign 0.00
IGL01795:Olfr414 APN 1 174430649 missense possibly damaging 0.83
IGL03286:Olfr414 APN 1 174431177 missense probably benign 0.01
PIT4131001:Olfr414 UTSW 1 174430824 missense probably damaging 1.00
R0219:Olfr414 UTSW 1 174430466 missense probably benign 0.00
R0492:Olfr414 UTSW 1 174430563 missense possibly damaging 0.95
R1052:Olfr414 UTSW 1 174431135 nonsense probably null
R1054:Olfr414 UTSW 1 174430853 missense probably benign 0.36
R1473:Olfr414 UTSW 1 174430643 missense probably damaging 0.97
R1675:Olfr414 UTSW 1 174431097 missense probably benign
R1774:Olfr414 UTSW 1 174431339 missense probably benign 0.00
R1861:Olfr414 UTSW 1 174431091 missense probably damaging 1.00
R1959:Olfr414 UTSW 1 174430905 missense probably damaging 1.00
R1978:Olfr414 UTSW 1 174431091 missense probably damaging 1.00
R4043:Olfr414 UTSW 1 174431091 missense probably damaging 1.00
R5020:Olfr414 UTSW 1 174430671 missense probably damaging 0.98
R5354:Olfr414 UTSW 1 174430686 missense probably damaging 0.98
R5873:Olfr414 UTSW 1 174430782 missense possibly damaging 0.84
R6053:Olfr414 UTSW 1 174430569 nonsense probably null
Z1176:Olfr414 UTSW 1 174430591 missense probably benign 0.39
Posted On2013-12-09