Incidental Mutation 'IGL01560:Slc13a4'
ID90833
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc13a4
Ensembl Gene ENSMUSG00000029843
Gene Namesolute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms9630060C05Rik, SUT1, SUT-1
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.747) question?
Stock #IGL01560
Quality Score
Status
Chromosome6
Chromosomal Location35267957-35308131 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 35271603 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000031868 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031868]
Predicted Effect probably benign
Transcript: ENSMUST00000031868
SMART Domains Protein: ENSMUSP00000031868
Gene: ENSMUSG00000029843

DomainStartEndE-ValueType
Pfam:Na_sulph_symp 5 609 3.2e-105 PFAM
Pfam:CitMHS 45 166 1.1e-15 PFAM
Pfam:CitMHS 251 531 8.9e-18 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display lethality before birth, impaired placental sulfate transport, failure of bone ossification, impaired vascular development, hemorrhaging, and cleft palate. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931440F15Rik A T 11: 29,824,643 Y271* probably null Het
Arhgap28 A T 17: 67,896,071 I129N probably damaging Het
Arsb A G 13: 93,807,598 I266V probably benign Het
Atp6v1b1 A G 6: 83,749,915 probably benign Het
Cacna1d C T 14: 30,099,206 V1118I probably benign Het
Cadps A T 14: 12,491,792 V791D probably damaging Het
Cdh2 T C 18: 16,650,438 D78G probably benign Het
Flnb T G 14: 7,893,829 I714S probably benign Het
Fzd1 A G 5: 4,756,037 M515T probably benign Het
Lrpprc A T 17: 84,708,119 F1288Y probably benign Het
Lrrk2 A G 15: 91,774,988 I1868V probably benign Het
Mmel1 A G 4: 154,892,510 D561G probably null Het
Mypn A T 10: 63,134,964 V887E probably benign Het
Olfr1223 C T 2: 89,144,603 C140Y probably damaging Het
Olfr414 A T 1: 174,430,901 M158L probably benign Het
Olfr846 T C 9: 19,360,546 T270A probably benign Het
Osbpl5 C A 7: 143,715,693 E49* probably null Het
Prpf8 A G 11: 75,490,406 Q189R possibly damaging Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Six6 T A 12: 72,940,057 M1K probably null Het
Slc17a1 T A 13: 23,874,629 I22N probably damaging Het
Thsd7b C T 1: 130,218,181 probably benign Het
Thumpd3 A G 6: 113,063,159 I335V possibly damaging Het
Ttn T C 2: 76,771,672 T18549A possibly damaging Het
Ugt2b37 G T 5: 87,251,839 P270Q probably damaging Het
Wdfy3 A T 5: 101,957,486 Y158* probably null Het
Zfp282 A T 6: 47,880,277 E148V probably damaging Het
Other mutations in Slc13a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00230:Slc13a4 APN 6 35289824 missense probably benign 0.01
IGL00975:Slc13a4 APN 6 35274975 missense probably benign 0.18
IGL01069:Slc13a4 APN 6 35268882 missense probably damaging 1.00
IGL01319:Slc13a4 APN 6 35307353 splice site probably null
IGL02125:Slc13a4 APN 6 35278288 missense probably benign 0.23
IGL02415:Slc13a4 APN 6 35283237 critical splice donor site probably null
IGL02888:Slc13a4 APN 6 35268840 missense probably benign 0.10
R0047:Slc13a4 UTSW 6 35287362 missense possibly damaging 0.84
R0047:Slc13a4 UTSW 6 35287362 missense possibly damaging 0.84
R0532:Slc13a4 UTSW 6 35287404 splice site probably null
R0747:Slc13a4 UTSW 6 35278328 missense probably damaging 1.00
R1391:Slc13a4 UTSW 6 35271662 missense probably damaging 0.96
R2106:Slc13a4 UTSW 6 35287864 missense probably damaging 0.99
R2253:Slc13a4 UTSW 6 35280483 missense probably benign 0.00
R3195:Slc13a4 UTSW 6 35268926 missense probably damaging 1.00
R3689:Slc13a4 UTSW 6 35268910 missense possibly damaging 0.87
R3698:Slc13a4 UTSW 6 35274957 missense probably benign 0.06
R3785:Slc13a4 UTSW 6 35287892 missense probably damaging 1.00
R3856:Slc13a4 UTSW 6 35271604 splice site probably null
R5400:Slc13a4 UTSW 6 35301842 nonsense probably null
R6142:Slc13a4 UTSW 6 35301783 missense probably damaging 0.99
R6645:Slc13a4 UTSW 6 35268839 missense probably benign 0.19
R6851:Slc13a4 UTSW 6 35301733 missense probably damaging 1.00
R7200:Slc13a4 UTSW 6 35287350 missense possibly damaging 0.56
R7513:Slc13a4 UTSW 6 35283337 intron probably null
R7590:Slc13a4 UTSW 6 35279463 missense possibly damaging 0.90
R7673:Slc13a4 UTSW 6 35276476 missense probably damaging 1.00
R7706:Slc13a4 UTSW 6 35270355 missense possibly damaging 0.92
Posted On2013-12-09