Incidental Mutation 'IGL01561:Olfr866'
ID90850
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr866
Ensembl Gene ENSMUSG00000050803
Gene Nameolfactory receptor 866
SynonymsMOR145-5, GA_x6K02T2PVTD-13768406-13767468
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL01561
Quality Score
Status
Chromosome9
Chromosomal Location20026959-20028035 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 20027522 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 139 (M139V)
Ref Sequence ENSEMBL: ENSMUSP00000054864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062248]
Predicted Effect probably benign
Transcript: ENSMUST00000062248
AA Change: M139V

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000054864
Gene: ENSMUSG00000050803
AA Change: M139V

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2e-47 PFAM
Pfam:7TM_GPCR_Srsx 38 282 8.7e-7 PFAM
Pfam:7tm_1 44 293 5.1e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212071
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aebp1 G A 11: 5,871,349 D583N probably damaging Het
Aoah T C 13: 20,905,735 probably benign Het
Aoah G T 13: 21,005,094 D496Y probably damaging Het
Cdh10 G T 15: 18,999,926 A486S possibly damaging Het
Cers2 A T 3: 95,322,161 probably null Het
Clec4a4 T A 6: 123,024,016 C229* probably null Het
Col15a1 T C 4: 47,312,118 V1311A possibly damaging Het
Fpr-rs3 C T 17: 20,624,597 G94D probably damaging Het
Fsd1 T A 17: 55,995,363 M269K probably benign Het
Golga2 A G 2: 32,296,677 M73V probably benign Het
Gusb A T 5: 129,998,086 V388E probably damaging Het
Heg1 A G 16: 33,766,668 N1267S probably benign Het
Htra4 A C 8: 25,033,571 I326S probably damaging Het
Klhl33 T C 14: 50,891,431 I780M probably benign Het
Mertk T C 2: 128,736,636 S181P probably damaging Het
Mpdz T C 4: 81,284,614 H1882R probably damaging Het
Muc13 A G 16: 33,806,041 K317E possibly damaging Het
Nek3 A G 8: 22,129,456 F440S probably damaging Het
Nrxn2 G A 19: 6,490,142 R831H probably damaging Het
Olfr1490 T C 19: 13,654,905 F159L probably benign Het
Olfr357 T A 2: 36,996,943 F44L probably benign Het
Palmd A T 3: 116,924,093 S252T probably damaging Het
Piezo2 C A 18: 63,124,614 M344I probably benign Het
Pygo1 T A 9: 72,945,288 N252K probably damaging Het
Rhobtb1 A G 10: 69,270,391 Q262R probably benign Het
Xpo1 T C 11: 23,282,706 Y409H possibly damaging Het
Zan T A 5: 137,463,866 E1017V unknown Het
Other mutations in Olfr866
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Olfr866 APN 9 20027047 missense probably damaging 1.00
IGL01554:Olfr866 APN 9 20027408 missense possibly damaging 0.55
IGL01597:Olfr866 APN 9 20027686 missense probably damaging 0.98
IGL02986:Olfr866 APN 9 20027711 missense probably benign 0.43
IGL03101:Olfr866 APN 9 20027429 missense probably benign 0.03
R0863:Olfr866 UTSW 9 20027213 missense probably damaging 1.00
R1747:Olfr866 UTSW 9 20027317 missense probably benign 0.01
R2121:Olfr866 UTSW 9 20027501 missense probably benign
R2124:Olfr866 UTSW 9 20027501 missense probably benign
R2240:Olfr866 UTSW 9 20027144 missense probably damaging 1.00
R3793:Olfr866 UTSW 9 20027063 missense probably damaging 1.00
R4498:Olfr866 UTSW 9 20027733 missense possibly damaging 0.50
R5084:Olfr866 UTSW 9 20027255 missense probably damaging 0.99
R5420:Olfr866 UTSW 9 20027059 missense probably damaging 0.98
R6314:Olfr866 UTSW 9 20027662 missense probably damaging 0.98
R6357:Olfr866 UTSW 9 20027629 missense probably damaging 1.00
R6588:Olfr866 UTSW 9 20027866 missense probably damaging 0.97
R6886:Olfr866 UTSW 9 20027132 missense probably benign 0.00
R7480:Olfr866 UTSW 9 20027934 start codon destroyed probably null
Z1088:Olfr866 UTSW 9 20027279 missense probably damaging 1.00
Posted On2013-12-09