Incidental Mutation 'IGL01566:Slc35f1'
| ID |
90990 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Slc35f1
|
| Ensembl Gene |
ENSMUSG00000038602 |
| Gene Name |
solute carrier family 35, member F1 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01566
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
52566629-52987718 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 52965551 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 322
(Y322C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105473]
|
| AlphaFold |
Q8BGK5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105473
AA Change: Y322C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: Y322C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
20 |
N/A |
INTRINSIC |
|
Pfam:SLC35F
|
56 |
355 |
1.4e-151 |
PFAM |
|
Pfam:CRT-like
|
66 |
315 |
2.3e-13 |
PFAM |
|
Pfam:EamA
|
217 |
355 |
1.7e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AB124611 |
T |
C |
9: 21,447,285 (GRCm39) |
V149A |
possibly damaging |
Het |
| Casc3 |
T |
C |
11: 98,714,227 (GRCm39) |
|
probably null |
Het |
| Dhdds |
T |
C |
4: 133,718,648 (GRCm39) |
I162V |
probably damaging |
Het |
| Dsg1a |
T |
C |
18: 20,469,840 (GRCm39) |
|
probably benign |
Het |
| E030025P04Rik |
T |
A |
11: 109,034,714 (GRCm39) |
D58V |
unknown |
Het |
| Gcn1 |
A |
G |
5: 115,749,117 (GRCm39) |
N1883S |
probably damaging |
Het |
| Gucy1a2 |
T |
C |
9: 3,634,661 (GRCm39) |
L235P |
probably damaging |
Het |
| Jkampl |
G |
A |
6: 73,445,673 (GRCm39) |
T292I |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,731,271 (GRCm39) |
N593S |
probably benign |
Het |
| Mme |
T |
C |
3: 63,269,350 (GRCm39) |
|
probably benign |
Het |
| Nr6a1 |
G |
T |
2: 38,617,901 (GRCm39) |
Q419K |
probably benign |
Het |
| Pcolce |
A |
G |
5: 137,603,422 (GRCm39) |
|
probably benign |
Het |
| Ppp2cb |
C |
A |
8: 34,101,791 (GRCm39) |
R110S |
probably benign |
Het |
| Slc5a3 |
T |
C |
16: 91,874,465 (GRCm39) |
V174A |
probably damaging |
Het |
| St8sia4 |
G |
T |
1: 95,581,482 (GRCm39) |
R87S |
probably benign |
Het |
| Tfdp2 |
A |
G |
9: 96,177,083 (GRCm39) |
E5G |
probably damaging |
Het |
| Tmem161b |
T |
C |
13: 84,442,881 (GRCm39) |
I267T |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,782,365 (GRCm39) |
L957P |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,612,445 (GRCm39) |
|
probably benign |
Het |
| Ubqln1 |
A |
T |
13: 58,327,481 (GRCm39) |
|
probably null |
Het |
| Wdfy3 |
A |
C |
5: 102,044,454 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Slc35f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00434:Slc35f1
|
APN |
10 |
52,938,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01073:Slc35f1
|
APN |
10 |
52,898,056 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL01433:Slc35f1
|
APN |
10 |
52,949,542 (GRCm39) |
splice site |
probably benign |
|
|
IGL02693:Slc35f1
|
APN |
10 |
52,809,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02870:Slc35f1
|
APN |
10 |
52,809,303 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03082:Slc35f1
|
APN |
10 |
52,809,234 (GRCm39) |
missense |
probably benign |
|
|
R0884:Slc35f1
|
UTSW |
10 |
52,965,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1340:Slc35f1
|
UTSW |
10 |
52,965,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Slc35f1
|
UTSW |
10 |
52,938,532 (GRCm39) |
splice site |
probably null |
|
|
R1813:Slc35f1
|
UTSW |
10 |
52,809,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Slc35f1
|
UTSW |
10 |
52,898,000 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2044:Slc35f1
|
UTSW |
10 |
52,965,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2518:Slc35f1
|
UTSW |
10 |
52,949,630 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3872:Slc35f1
|
UTSW |
10 |
52,898,006 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3934:Slc35f1
|
UTSW |
10 |
52,984,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3935:Slc35f1
|
UTSW |
10 |
52,984,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3936:Slc35f1
|
UTSW |
10 |
52,984,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4118:Slc35f1
|
UTSW |
10 |
52,965,464 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4921:Slc35f1
|
UTSW |
10 |
52,938,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5116:Slc35f1
|
UTSW |
10 |
52,897,991 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5378:Slc35f1
|
UTSW |
10 |
52,567,157 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5387:Slc35f1
|
UTSW |
10 |
52,984,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5500:Slc35f1
|
UTSW |
10 |
52,809,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5590:Slc35f1
|
UTSW |
10 |
52,984,274 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5743:Slc35f1
|
UTSW |
10 |
52,965,546 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5916:Slc35f1
|
UTSW |
10 |
52,809,317 (GRCm39) |
nonsense |
probably null |
|
|
R6985:Slc35f1
|
UTSW |
10 |
52,898,007 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7068:Slc35f1
|
UTSW |
10 |
52,938,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7295:Slc35f1
|
UTSW |
10 |
52,938,637 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7427:Slc35f1
|
UTSW |
10 |
52,965,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7428:Slc35f1
|
UTSW |
10 |
52,965,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8334:Slc35f1
|
UTSW |
10 |
52,984,244 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
| Posted On |
2013-12-09 |
Incidental Mutation