Incidental Mutation 'IGL01566:Slc35f1'
| ID |
90990 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Slc35f1
|
| Ensembl Gene |
ENSMUSG00000038602 |
| Gene Name |
solute carrier family 35, member F1 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01566
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
52690533-53111622 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 53089455 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 322
(Y322C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105473]
|
| AlphaFold |
Q8BGK5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105473
AA Change: Y322C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: Y322C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
20 |
N/A |
INTRINSIC |
|
Pfam:SLC35F
|
56 |
355 |
1.4e-151 |
PFAM |
|
Pfam:CRT-like
|
66 |
315 |
2.3e-13 |
PFAM |
|
Pfam:EamA
|
217 |
355 |
1.7e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931417E11Rik |
G |
A |
6: 73,468,690 (GRCm38) |
T292I |
probably damaging |
Het |
| AB124611 |
T |
C |
9: 21,535,989 (GRCm38) |
V149A |
possibly damaging |
Het |
| Casc3 |
T |
C |
11: 98,823,401 (GRCm38) |
|
probably null |
Het |
| Dhdds |
T |
C |
4: 133,991,337 (GRCm38) |
I162V |
probably damaging |
Het |
| Dsg1a |
T |
C |
18: 20,336,783 (GRCm38) |
|
probably benign |
Het |
| E030025P04Rik |
T |
A |
11: 109,143,888 (GRCm38) |
D58V |
unknown |
Het |
| Gcn1l1 |
A |
G |
5: 115,611,058 (GRCm38) |
N1883S |
probably damaging |
Het |
| Gucy1a2 |
T |
C |
9: 3,634,661 (GRCm38) |
L235P |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,823,964 (GRCm38) |
N593S |
probably benign |
Het |
| Mme |
T |
C |
3: 63,361,929 (GRCm38) |
|
probably benign |
Het |
| Nr6a1 |
G |
T |
2: 38,727,889 (GRCm38) |
Q419K |
probably benign |
Het |
| Pcolce |
A |
G |
5: 137,605,160 (GRCm38) |
|
probably benign |
Het |
| Ppp2cb |
C |
A |
8: 33,611,763 (GRCm38) |
R110S |
probably benign |
Het |
| Slc5a3 |
T |
C |
16: 92,077,577 (GRCm38) |
V174A |
probably damaging |
Het |
| St8sia4 |
G |
T |
1: 95,653,757 (GRCm38) |
R87S |
probably benign |
Het |
| Tfdp2 |
A |
G |
9: 96,295,030 (GRCm38) |
E5G |
probably damaging |
Het |
| Tmem161b |
T |
C |
13: 84,294,762 (GRCm38) |
I267T |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,952,021 (GRCm38) |
L957P |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,782,101 (GRCm38) |
|
probably benign |
Het |
| Ubqln1 |
A |
T |
13: 58,179,667 (GRCm38) |
|
probably null |
Het |
| Wdfy3 |
A |
C |
5: 101,896,588 (GRCm38) |
|
probably benign |
Het |
|
| Other mutations in Slc35f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00434:Slc35f1
|
APN |
10 |
53,062,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01073:Slc35f1
|
APN |
10 |
53,021,960 (GRCm38) |
missense |
probably benign |
0.16 |
|
IGL01433:Slc35f1
|
APN |
10 |
53,073,446 (GRCm38) |
splice site |
probably benign |
|
|
IGL02693:Slc35f1
|
APN |
10 |
52,933,128 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02870:Slc35f1
|
APN |
10 |
52,933,207 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL03082:Slc35f1
|
APN |
10 |
52,933,138 (GRCm38) |
missense |
probably benign |
|
|
R0884:Slc35f1
|
UTSW |
10 |
53,089,347 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1340:Slc35f1
|
UTSW |
10 |
53,089,454 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1781:Slc35f1
|
UTSW |
10 |
53,062,436 (GRCm38) |
splice site |
probably null |
|
|
R1813:Slc35f1
|
UTSW |
10 |
52,933,195 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1908:Slc35f1
|
UTSW |
10 |
53,021,904 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R2044:Slc35f1
|
UTSW |
10 |
53,089,347 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2518:Slc35f1
|
UTSW |
10 |
53,073,534 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3872:Slc35f1
|
UTSW |
10 |
53,021,910 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R3934:Slc35f1
|
UTSW |
10 |
53,108,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3935:Slc35f1
|
UTSW |
10 |
53,108,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3936:Slc35f1
|
UTSW |
10 |
53,108,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4118:Slc35f1
|
UTSW |
10 |
53,089,368 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4921:Slc35f1
|
UTSW |
10 |
53,062,602 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5116:Slc35f1
|
UTSW |
10 |
53,021,895 (GRCm38) |
missense |
probably benign |
0.39 |
|
R5378:Slc35f1
|
UTSW |
10 |
52,691,061 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R5387:Slc35f1
|
UTSW |
10 |
53,108,164 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5500:Slc35f1
|
UTSW |
10 |
52,933,222 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5590:Slc35f1
|
UTSW |
10 |
53,108,178 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R5743:Slc35f1
|
UTSW |
10 |
53,089,450 (GRCm38) |
missense |
probably benign |
0.06 |
|
R5916:Slc35f1
|
UTSW |
10 |
52,933,221 (GRCm38) |
nonsense |
probably null |
|
|
R6985:Slc35f1
|
UTSW |
10 |
53,021,911 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7068:Slc35f1
|
UTSW |
10 |
53,062,500 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7295:Slc35f1
|
UTSW |
10 |
53,062,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7427:Slc35f1
|
UTSW |
10 |
53,089,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7428:Slc35f1
|
UTSW |
10 |
53,089,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8334:Slc35f1
|
UTSW |
10 |
53,108,148 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
| Posted On |
2013-12-09 |
Incidental Mutation