Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01567:Map10'

91027

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Map10

Ensembl Gene

Gene Name

microtubule-associated protein 10

Synonyms

4933403G14Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL01567

Quality Score

Status

Chromosome

Chromosomal Location

125669818-125673359 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 125671493 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 542 (Q542K)

Ref Sequence

ENSEMBL: ENSMUSP00000061679 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053078]

Predicted Effect

probably benign
Transcript: ENSMUST00000053078
AA Change: Q542K

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000061679
Gene: ENSMUSG00000050930
AA Change: Q542K

Domain	Start	End	E-Value	Type
low complexity region	38	54	N/A	INTRINSIC
low complexity region	68	91	N/A	INTRINSIC
Pfam:HPHLAWLY	243	535	1.4e-130	PFAM
Pfam:HPHLAWLY	527	890	9.1e-133	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl1	A	G	7: 76,421,880	S317G	probably benign	Het
Akna	T	C	4: 63,381,850	T652A	probably benign	Het
Anxa9	G	A	3: 95,302,432		probably benign	Het
Bpifb4	T	A	2: 153,947,278		probably benign	Het
Bptf	A	G	11: 107,058,774	S2125P	probably damaging	Het
Capns2	C	A	8: 92,902,006	H174Q	probably benign	Het
Cd200	A	C	16: 45,394,691	L199R	probably damaging	Het
Clasp2	T	C	9: 113,880,096	V651A	probably damaging	Het
Cox18	G	A	5: 90,217,588	Q251*	probably null	Het
Depdc1a	T	C	3: 159,526,546	S645P	probably damaging	Het
Dio3	T	A	12: 110,279,427	C66S	possibly damaging	Het
Dock9	A	T	14: 121,653,084	L258Q	probably damaging	Het
Ghrhr	A	G	6: 55,384,123	D274G	probably damaging	Het
Gm5129	A	G	5: 29,735,864		probably benign	Het
Grb7	A	G	11: 98,454,950	N518S	probably damaging	Het
Kdm5b	G	A	1: 134,602,540	A430T	probably damaging	Het
Metap1	T	C	3: 138,462,389	T325A	probably damaging	Het
Ncan	A	T	8: 70,108,334	M661K	probably benign	Het
Olfr38	T	C	6: 42,762,727	I225T	probably benign	Het
Olfr572	A	G	7: 102,928,416	I263V	probably benign	Het
Otog	T	C	7: 46,276,615		probably benign	Het
Pip4k2b	T	C	11: 97,729,561	D116G	probably damaging	Het
Rps15	T	A	10: 80,293,809	L86Q	probably benign	Het
Sfxn4	G	T	19: 60,853,898	T122K	probably damaging	Het
Slc4a3	T	C	1: 75,550,882	V165A	probably damaging	Het
Spata48	A	G	11: 11,515,015	H122R	possibly damaging	Het
Synm	A	G	7: 67,735,232	V452A	probably damaging	Het
Tdpoz1	T	C	3: 93,670,706	H257R	possibly damaging	Het
Tmem26	A	G	10: 68,751,231	T170A	probably damaging	Het
Wdfy4	T	G	14: 33,151,661	E230D	probably benign	Het

Other mutations in Map10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00813:Map10	APN	8	125671932	missense	probably benign	0.00
IGL02566:Map10	APN	8	125671755	missense	probably benign
IGL03088:Map10	APN	8	125671070	missense	probably benign	0.14
debauched	UTSW	8	125671245	missense	probably damaging	1.00
R1083:Map10	UTSW	8	125670439	nonsense	probably null
R1543:Map10	UTSW	8	125670872	missense	probably benign	0.00
R3155:Map10	UTSW	8	125671574	missense	possibly damaging	0.79
R4076:Map10	UTSW	8	125671845	missense	probably benign	0.23
R4559:Map10	UTSW	8	125671814	missense	probably benign
R4856:Map10	UTSW	8	125670692	missense	probably damaging	1.00
R4886:Map10	UTSW	8	125670692	missense	probably damaging	1.00
R5412:Map10	UTSW	8	125670985	missense	probably damaging	1.00
R6034:Map10	UTSW	8	125672466	missense	probably damaging	1.00
R6034:Map10	UTSW	8	125672466	missense	probably damaging	1.00
R6150:Map10	UTSW	8	125671589	missense	probably damaging	0.96
R6351:Map10	UTSW	8	125671245	missense	probably damaging	1.00
R6466:Map10	UTSW	8	125672384	nonsense	probably null
R6544:Map10	UTSW	8	125671374	missense	probably benign	0.00
R6557:Map10	UTSW	8	125670252	missense	probably damaging	0.98
R6821:Map10	UTSW	8	125670399	missense	probably benign	0.01
R7096:Map10	UTSW	8	125671923	missense	probably damaging	0.99
R7128:Map10	UTSW	8	125671853	missense	probably benign
R7177:Map10	UTSW	8	125671845	missense	probably benign	0.23
R7237:Map10	UTSW	8	125671224	missense	probably benign	0.03
Z1088:Map10	UTSW	8	125671931	frame shift	probably null

Posted On

2013-12-09