Incidental Mutation 'IGL01568:Or5bw2'
| ID |
91032 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or5bw2
|
| Ensembl Gene |
ENSMUSG00000056696 |
| Gene Name |
olfactory receptor family 5 subfamily BW member 2 |
| Synonyms |
GA_x6K02T2QGBW-3300391-3301317, MOR222-3, Olfr1350 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL01568
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
6572992-6573918 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 6573569 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 193
(H193L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151318
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070985]
[ENSMUST00000207221]
[ENSMUST00000219278]
|
| AlphaFold |
Q8VF34 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000070985
AA Change: H193L
PolyPhen 2
Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000069927
Gene: ENSMUSG00000056696
AA Change: H193L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
29 |
305 |
1.6e-50 |
PFAM |
|
Pfam:7tm_1
|
39 |
288 |
8.2e-20 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000207221
AA Change: H193L
PolyPhen 2
Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000219278
AA Change: H193L
PolyPhen 2
Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap13 |
T |
A |
7: 75,258,270 (GRCm39) |
L298* |
probably null |
Het |
| Capn15 |
G |
T |
17: 26,184,419 (GRCm39) |
R21S |
probably damaging |
Het |
| Cbs |
A |
G |
17: 31,840,488 (GRCm39) |
L290P |
possibly damaging |
Het |
| Dnah5 |
T |
C |
15: 28,229,798 (GRCm39) |
I144T |
probably benign |
Het |
| Dok4 |
T |
A |
8: 95,593,430 (GRCm39) |
I119F |
probably benign |
Het |
| Dpp9 |
T |
C |
17: 56,498,159 (GRCm39) |
N599S |
probably benign |
Het |
| Ep400 |
T |
C |
5: 110,867,361 (GRCm39) |
T984A |
unknown |
Het |
| Fcrl2 |
T |
C |
3: 87,163,986 (GRCm39) |
N381S |
probably damaging |
Het |
| Fhod3 |
A |
G |
18: 25,253,219 (GRCm39) |
I1390V |
probably benign |
Het |
| Gabbr1 |
A |
G |
17: 37,381,561 (GRCm39) |
Y775C |
probably damaging |
Het |
| Gimap9 |
A |
G |
6: 48,654,550 (GRCm39) |
T46A |
probably benign |
Het |
| Gm3696 |
T |
C |
14: 18,435,020 (GRCm39) |
N88S |
probably benign |
Het |
| Gm5277 |
A |
G |
3: 78,799,743 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr153 |
C |
A |
4: 152,366,825 (GRCm39) |
|
probably null |
Het |
| Hgf |
A |
T |
5: 16,769,812 (GRCm39) |
K95N |
probably damaging |
Het |
| Igf2r |
A |
G |
17: 12,902,872 (GRCm39) |
S2393P |
possibly damaging |
Het |
| Ikbke |
C |
A |
1: 131,185,633 (GRCm39) |
|
probably null |
Het |
| Il17re |
G |
T |
6: 113,447,013 (GRCm39) |
R588L |
probably damaging |
Het |
| Itch |
T |
C |
2: 155,054,382 (GRCm39) |
|
probably benign |
Het |
| Krt1c |
T |
A |
15: 101,721,646 (GRCm39) |
D465V |
probably damaging |
Het |
| Krt28 |
G |
T |
11: 99,262,243 (GRCm39) |
P249Q |
probably damaging |
Het |
| Lax1 |
A |
T |
1: 133,608,038 (GRCm39) |
D234E |
probably benign |
Het |
| Mtmr3 |
A |
G |
11: 4,477,861 (GRCm39) |
I61T |
probably damaging |
Het |
| Naip5 |
G |
T |
13: 100,353,609 (GRCm39) |
Q1217K |
probably benign |
Het |
| Nt5dc3 |
A |
G |
10: 86,669,802 (GRCm39) |
T466A |
probably benign |
Het |
| Or8s2 |
T |
C |
15: 98,276,787 (GRCm39) |
D68G |
probably damaging |
Het |
| Pcdhb3 |
T |
C |
18: 37,435,054 (GRCm39) |
V340A |
possibly damaging |
Het |
| Pclo |
C |
T |
5: 14,728,443 (GRCm39) |
|
probably benign |
Het |
| Piezo2 |
C |
T |
18: 63,163,463 (GRCm39) |
V2152I |
probably benign |
Het |
| Pip4k2b |
A |
T |
11: 97,620,378 (GRCm39) |
|
probably null |
Het |
| Ptprs |
G |
A |
17: 56,720,958 (GRCm39) |
H1432Y |
probably damaging |
Het |
| Rars1 |
A |
G |
11: 35,716,808 (GRCm39) |
|
probably benign |
Het |
| Scrn1 |
A |
G |
6: 54,499,739 (GRCm39) |
|
probably benign |
Het |
| Sdr42e1 |
T |
C |
8: 118,390,182 (GRCm39) |
Y153C |
probably damaging |
Het |
| Slc18a1 |
A |
T |
8: 69,518,278 (GRCm39) |
S245R |
probably damaging |
Het |
| Spmip4 |
A |
G |
6: 50,550,678 (GRCm39) |
|
probably benign |
Het |
| Tns1 |
T |
G |
1: 73,992,668 (GRCm39) |
D670A |
probably damaging |
Het |
| Trim16 |
T |
A |
11: 62,711,684 (GRCm39) |
D118E |
probably benign |
Het |
| Trpv1 |
A |
G |
11: 73,129,269 (GRCm39) |
D62G |
probably benign |
Het |
| Tyr |
A |
G |
7: 87,087,156 (GRCm39) |
L452P |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,148,684 (GRCm39) |
C1723R |
probably damaging |
Het |
| Uqcrb |
G |
A |
13: 67,049,459 (GRCm39) |
|
probably benign |
Het |
| Vax2 |
G |
T |
6: 83,688,519 (GRCm39) |
V81L |
possibly damaging |
Het |
| Zan |
A |
G |
5: 137,463,106 (GRCm39) |
V691A |
unknown |
Het |
| Zfp335 |
A |
G |
2: 164,736,708 (GRCm39) |
S976P |
possibly damaging |
Het |
| Zfp384 |
C |
T |
6: 125,001,095 (GRCm39) |
P56S |
probably damaging |
Het |
|
| Other mutations in Or5bw2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00330:Or5bw2
|
APN |
7 |
6,573,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01387:Or5bw2
|
APN |
7 |
6,573,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Or5bw2
|
APN |
7 |
6,573,211 (GRCm39) |
missense |
probably benign |
0.12 |
|
I2288:Or5bw2
|
UTSW |
7 |
6,573,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
I2289:Or5bw2
|
UTSW |
7 |
6,573,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Or5bw2
|
UTSW |
7 |
6,573,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0558:Or5bw2
|
UTSW |
7 |
6,573,652 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1103:Or5bw2
|
UTSW |
7 |
6,573,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1352:Or5bw2
|
UTSW |
7 |
6,573,782 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1503:Or5bw2
|
UTSW |
7 |
6,573,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1630:Or5bw2
|
UTSW |
7 |
6,573,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1981:Or5bw2
|
UTSW |
7 |
6,573,557 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2228:Or5bw2
|
UTSW |
7 |
6,573,802 (GRCm39) |
missense |
probably benign |
|
|
R2258:Or5bw2
|
UTSW |
7 |
6,573,022 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2259:Or5bw2
|
UTSW |
7 |
6,573,022 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2260:Or5bw2
|
UTSW |
7 |
6,573,022 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4075:Or5bw2
|
UTSW |
7 |
6,573,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4750:Or5bw2
|
UTSW |
7 |
6,573,850 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4917:Or5bw2
|
UTSW |
7 |
6,573,643 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4918:Or5bw2
|
UTSW |
7 |
6,573,643 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5571:Or5bw2
|
UTSW |
7 |
6,573,824 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5915:Or5bw2
|
UTSW |
7 |
6,573,172 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6969:Or5bw2
|
UTSW |
7 |
6,573,320 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7061:Or5bw2
|
UTSW |
7 |
6,573,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7286:Or5bw2
|
UTSW |
7 |
6,573,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7510:Or5bw2
|
UTSW |
7 |
6,572,960 (GRCm39) |
start gained |
probably benign |
|
|
R9475:Or5bw2
|
UTSW |
7 |
6,573,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V1662:Or5bw2
|
UTSW |
7 |
6,573,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Or5bw2
|
UTSW |
7 |
6,573,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation