Incidental Mutation 'IGL01568:Fcrls'
ID 91050
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcrls
Ensembl Gene ENSMUSG00000015852
Gene Name Fc receptor-like S, scavenger receptor
Synonyms IFGP2, Msr2, Fcrh2, moFcRH2sc, 2810439C17Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock # IGL01568
Quality Score
Status
Chromosome 3
Chromosomal Location 87250758-87263738 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87256679 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 381 (N381S)
Ref Sequence ENSEMBL: ENSMUSP00000088508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090986] [ENSMUST00000146512]
AlphaFold Q9EQY5
Predicted Effect probably damaging
Transcript: ENSMUST00000090986
AA Change: N381S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000088508
Gene: ENSMUSG00000015852
AA Change: N381S

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
IGc2 122 186 2.77e-6 SMART
IGc2 226 291 1.09e-4 SMART
IG 315 396 1e-3 SMART
SR 402 503 7.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146512
SMART Domains Protein: ENSMUSP00000115780
Gene: ENSMUSG00000015852

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
Pfam:Ig_2 111 176 6.1e-6 PFAM
Pfam:Ig_3 111 176 1.4e-4 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Female homozygous mutant mice are larger than controls and show increased mean body weight, total tissue mass, lean body mass and total body fat. Homozygous mutant mice eshow a decreased mean percentage of CD8 cells in the peripheral blood. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921507P07Rik A G 6: 50,573,698 probably benign Het
Akap13 T A 7: 75,608,522 L298* probably null Het
Capn15 G T 17: 25,965,445 R21S probably damaging Het
Cbs A G 17: 31,621,514 L290P possibly damaging Het
Dnah5 T C 15: 28,229,652 I144T probably benign Het
Dok4 T A 8: 94,866,802 I119F probably benign Het
Dpp9 T C 17: 56,191,159 N599S probably benign Het
Ep400 T C 5: 110,719,495 T984A unknown Het
Fhod3 A G 18: 25,120,162 I1390V probably benign Het
Gabbr1 A G 17: 37,070,669 Y775C probably damaging Het
Gimap9 A G 6: 48,677,616 T46A probably benign Het
Gm3696 T C 14: 7,089,819 N88S probably benign Het
Gm5277 A G 3: 78,892,436 noncoding transcript Het
Gpr153 C A 4: 152,282,368 probably null Het
Hgf A T 5: 16,564,814 K95N probably damaging Het
Igf2r A G 17: 12,683,985 S2393P possibly damaging Het
Ikbke C A 1: 131,257,896 probably null Het
Il17re G T 6: 113,470,052 R588L probably damaging Het
Itch T C 2: 155,212,462 probably benign Het
Krt2 T A 15: 101,813,211 D465V probably damaging Het
Krt28 G T 11: 99,371,417 P249Q probably damaging Het
Lax1 A T 1: 133,680,300 D234E probably benign Het
Mtmr3 A G 11: 4,527,861 I61T probably damaging Het
Naip5 G T 13: 100,217,101 Q1217K probably benign Het
Nt5dc3 A G 10: 86,833,938 T466A probably benign Het
Olfr1350 A T 7: 6,570,570 H193L possibly damaging Het
Olfr283 T C 15: 98,378,906 D68G probably damaging Het
Pcdhb3 T C 18: 37,302,001 V340A possibly damaging Het
Pclo C T 5: 14,678,429 probably benign Het
Piezo2 C T 18: 63,030,392 V2152I probably benign Het
Pip4k2b A T 11: 97,729,552 probably null Het
Ptprs G A 17: 56,413,958 H1432Y probably damaging Het
Rars A G 11: 35,825,981 probably benign Het
Scrn1 A G 6: 54,522,754 probably benign Het
Sdr42e1 T C 8: 117,663,443 Y153C probably damaging Het
Slc18a1 A T 8: 69,065,626 S245R probably damaging Het
Tns1 T G 1: 73,953,509 D670A probably damaging Het
Trim16 T A 11: 62,820,858 D118E probably benign Het
Trpv1 A G 11: 73,238,443 D62G probably benign Het
Tyr A G 7: 87,437,948 L452P probably damaging Het
Ubr4 T C 4: 139,421,373 C1723R probably damaging Het
Uqcrb G A 13: 66,901,395 probably benign Het
Vax2 G T 6: 83,711,537 V81L possibly damaging Het
Zan A G 5: 137,464,844 V691A unknown Het
Zfp335 A G 2: 164,894,788 S976P possibly damaging Het
Zfp384 C T 6: 125,024,132 P56S probably damaging Het
Other mutations in Fcrls
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01959:Fcrls APN 3 87259632 missense probably damaging 0.97
IGL02409:Fcrls APN 3 87252723 missense probably benign 0.00
IGL02677:Fcrls APN 3 87259387 missense probably benign 0.01
IGL02957:Fcrls APN 3 87262194 missense possibly damaging 0.59
IGL02974:Fcrls APN 3 87257397 missense possibly damaging 0.89
IGL02992:Fcrls APN 3 87259466 missense probably damaging 0.99
BB001:Fcrls UTSW 3 87259533 missense probably damaging 0.99
BB011:Fcrls UTSW 3 87259533 missense probably damaging 0.99
R0052:Fcrls UTSW 3 87256778 missense possibly damaging 0.94
R0052:Fcrls UTSW 3 87256778 missense possibly damaging 0.94
R0131:Fcrls UTSW 3 87258959 missense possibly damaging 0.90
R1171:Fcrls UTSW 3 87256860 missense probably benign 0.24
R1319:Fcrls UTSW 3 87262177 critical splice donor site probably null
R1522:Fcrls UTSW 3 87256707 missense possibly damaging 0.64
R1696:Fcrls UTSW 3 87259518 missense possibly damaging 0.95
R1742:Fcrls UTSW 3 87259043 missense possibly damaging 0.76
R2156:Fcrls UTSW 3 87257341 missense probably benign 0.43
R2255:Fcrls UTSW 3 87257348 nonsense probably null
R2257:Fcrls UTSW 3 87259621 missense probably damaging 0.99
R2434:Fcrls UTSW 3 87256698 missense probably damaging 1.00
R2680:Fcrls UTSW 3 87257349 missense probably damaging 0.99
R3552:Fcrls UTSW 3 87259410 missense possibly damaging 0.73
R4866:Fcrls UTSW 3 87263466 missense possibly damaging 0.65
R4883:Fcrls UTSW 3 87259615 missense possibly damaging 0.48
R5654:Fcrls UTSW 3 87257544 missense probably benign
R5771:Fcrls UTSW 3 87263468 missense probably damaging 0.98
R5917:Fcrls UTSW 3 87256787 missense probably damaging 0.99
R6349:Fcrls UTSW 3 87252496 missense probably damaging 0.99
R6562:Fcrls UTSW 3 87257328 missense probably benign
R6954:Fcrls UTSW 3 87263676 critical splice donor site probably benign
R7059:Fcrls UTSW 3 87257340 missense possibly damaging 0.82
R7188:Fcrls UTSW 3 87259523 missense probably benign 0.13
R7201:Fcrls UTSW 3 87252627 missense probably damaging 0.99
R7369:Fcrls UTSW 3 87256701 missense possibly damaging 0.59
R7431:Fcrls UTSW 3 87258926 missense probably damaging 0.99
R7610:Fcrls UTSW 3 87252697 missense probably damaging 1.00
R7924:Fcrls UTSW 3 87259533 missense probably damaging 0.99
R8018:Fcrls UTSW 3 87259626 nonsense probably null
R8280:Fcrls UTSW 3 87259057 nonsense probably null
R8981:Fcrls UTSW 3 87257370 missense probably damaging 1.00
R9368:Fcrls UTSW 3 87257599 missense possibly damaging 0.59
R9477:Fcrls UTSW 3 87252496 missense probably damaging 0.98
R9522:Fcrls UTSW 3 87256794 missense possibly damaging 0.95
Posted On 2013-12-09