Incidental Mutation 'IGL00519:Atg10'
ID 9106
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Atg10
Ensembl Gene ENSMUSG00000021619
Gene Name autophagy related 10
Synonyms APG10, Apg10l, 5430428K15Rik, 5330424L23Rik, Apg10p
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL00519
Quality Score
Status
Chromosome 13
Chromosomal Location 91083475-91372087 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 91302330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022119] [ENSMUST00000224449]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000022119
SMART Domains Protein: ENSMUSP00000022119
Gene: ENSMUSG00000021619

DomainStartEndE-ValueType
Pfam:Autophagy_act_C 95 162 9.1e-19 PFAM
low complexity region 188 202 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224449
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A T 8: 44,022,562 (GRCm39) N309K probably damaging Het
Asap1 G A 15: 63,982,791 (GRCm39) P846S probably damaging Het
Cdk18 C A 1: 132,043,226 (GRCm39) R433L probably benign Het
Celsr1 A G 15: 85,915,037 (GRCm39) Y979H probably damaging Het
Cracr2b T C 7: 141,045,670 (GRCm39) probably benign Het
Csmd2 T C 4: 128,377,266 (GRCm39) F2049L probably benign Het
Cubn T C 2: 13,287,730 (GRCm39) N3450D probably benign Het
Dmrt1 T C 19: 25,580,638 (GRCm39) L350P probably damaging Het
Dnah5 A T 15: 28,444,364 (GRCm39) D4054V probably benign Het
Dpp8 A T 9: 64,985,290 (GRCm39) T783S probably damaging Het
Enpp3 T C 10: 24,663,670 (GRCm39) T564A probably benign Het
Exoc6b T C 6: 84,966,435 (GRCm39) K180E probably benign Het
Faf1 T A 4: 109,697,578 (GRCm39) F301L probably benign Het
Fbxo7 A T 10: 85,864,928 (GRCm39) E77V probably damaging Het
Gabpa T G 16: 84,657,489 (GRCm39) *455G probably null Het
Hexim2 A T 11: 103,024,905 (GRCm39) M1L probably benign Het
Lrrc24 T A 15: 76,602,263 (GRCm39) N164I probably damaging Het
Lrrc8b G A 5: 105,629,591 (GRCm39) A646T possibly damaging Het
Mansc1 T A 6: 134,587,769 (GRCm39) Q136L possibly damaging Het
Mlxip T A 5: 123,585,268 (GRCm39) V592E probably benign Het
Ncor2 T C 5: 125,161,988 (GRCm39) T429A unknown Het
Tbcd A G 11: 121,466,147 (GRCm39) N591S probably damaging Het
Tenm4 T C 7: 96,454,345 (GRCm39) probably benign Het
Uri1 A G 7: 37,660,978 (GRCm39) S522P probably damaging Het
Ush2a C T 1: 188,176,865 (GRCm39) S1343L probably benign Het
Other mutations in Atg10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03131:Atg10 APN 13 91,085,412 (GRCm39) missense probably null 0.99
R0362:Atg10 UTSW 13 91,189,109 (GRCm39) critical splice acceptor site probably null
R0826:Atg10 UTSW 13 91,084,705 (GRCm39) critical splice donor site probably null
R1593:Atg10 UTSW 13 91,302,380 (GRCm39) missense probably benign 0.02
R2918:Atg10 UTSW 13 91,189,027 (GRCm39) missense probably damaging 1.00
R3012:Atg10 UTSW 13 91,302,397 (GRCm39) missense probably damaging 0.99
R3036:Atg10 UTSW 13 91,189,017 (GRCm39) missense probably damaging 1.00
R3837:Atg10 UTSW 13 91,085,499 (GRCm39) missense probably damaging 1.00
R3838:Atg10 UTSW 13 91,085,499 (GRCm39) missense probably damaging 1.00
R3839:Atg10 UTSW 13 91,085,499 (GRCm39) missense probably damaging 1.00
R4324:Atg10 UTSW 13 91,189,085 (GRCm39) missense probably damaging 1.00
R6195:Atg10 UTSW 13 91,356,555 (GRCm39) splice site probably null
R6478:Atg10 UTSW 13 91,085,466 (GRCm39) missense probably damaging 1.00
R8287:Atg10 UTSW 13 91,170,799 (GRCm39) splice site probably benign
R9036:Atg10 UTSW 13 91,189,071 (GRCm39) missense probably benign 0.07
R9151:Atg10 UTSW 13 91,189,032 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-06