Incidental Mutation 'IGL01568:Naip5'
ID 91060
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Naip5
Ensembl Gene ENSMUSG00000071203
Gene Name NLR family, apoptosis inhibitory protein 5
Synonyms Birc1e, Lgn1, Naip-rs3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL01568
Quality Score
Status
Chromosome 13
Chromosomal Location 100211739-100246323 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 100217101 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 1217 (Q1217K)
Ref Sequence ENSEMBL: ENSMUSP00000058611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049789]
AlphaFold Q9R016
Predicted Effect probably benign
Transcript: ENSMUST00000049789
AA Change: Q1217K

PolyPhen 2 Score 0.262 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000058611
Gene: ENSMUSG00000071203
AA Change: Q1217K

DomainStartEndE-ValueType
low complexity region 36 51 N/A INTRINSIC
BIR 58 129 1.08e-19 SMART
BIR 157 229 1.06e-36 SMART
BIR 276 347 2.14e-32 SMART
Pfam:NACHT 464 618 1.7e-36 PFAM
low complexity region 851 862 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921507P07Rik A G 6: 50,573,698 (GRCm38) probably benign Het
Akap13 T A 7: 75,608,522 (GRCm38) L298* probably null Het
Capn15 G T 17: 25,965,445 (GRCm38) R21S probably damaging Het
Cbs A G 17: 31,621,514 (GRCm38) L290P possibly damaging Het
Dnah5 T C 15: 28,229,652 (GRCm38) I144T probably benign Het
Dok4 T A 8: 94,866,802 (GRCm38) I119F probably benign Het
Dpp9 T C 17: 56,191,159 (GRCm38) N599S probably benign Het
Ep400 T C 5: 110,719,495 (GRCm38) T984A unknown Het
Fcrls T C 3: 87,256,679 (GRCm38) N381S probably damaging Het
Fhod3 A G 18: 25,120,162 (GRCm38) I1390V probably benign Het
Gabbr1 A G 17: 37,070,669 (GRCm38) Y775C probably damaging Het
Gimap9 A G 6: 48,677,616 (GRCm38) T46A probably benign Het
Gm3696 T C 14: 7,089,819 (GRCm38) N88S probably benign Het
Gm5277 A G 3: 78,892,436 (GRCm38) noncoding transcript Het
Gpr153 C A 4: 152,282,368 (GRCm38) probably null Het
Hgf A T 5: 16,564,814 (GRCm38) K95N probably damaging Het
Igf2r A G 17: 12,683,985 (GRCm38) S2393P possibly damaging Het
Ikbke C A 1: 131,257,896 (GRCm38) probably null Het
Il17re G T 6: 113,470,052 (GRCm38) R588L probably damaging Het
Itch T C 2: 155,212,462 (GRCm38) probably benign Het
Krt2 T A 15: 101,813,211 (GRCm38) D465V probably damaging Het
Krt28 G T 11: 99,371,417 (GRCm38) P249Q probably damaging Het
Lax1 A T 1: 133,680,300 (GRCm38) D234E probably benign Het
Mtmr3 A G 11: 4,527,861 (GRCm38) I61T probably damaging Het
Nt5dc3 A G 10: 86,833,938 (GRCm38) T466A probably benign Het
Olfr1350 A T 7: 6,570,570 (GRCm38) H193L possibly damaging Het
Olfr283 T C 15: 98,378,906 (GRCm38) D68G probably damaging Het
Pcdhb3 T C 18: 37,302,001 (GRCm38) V340A possibly damaging Het
Pclo C T 5: 14,678,429 (GRCm38) probably benign Het
Piezo2 C T 18: 63,030,392 (GRCm38) V2152I probably benign Het
Pip4k2b A T 11: 97,729,552 (GRCm38) probably null Het
Ptprs G A 17: 56,413,958 (GRCm38) H1432Y probably damaging Het
Rars A G 11: 35,825,981 (GRCm38) probably benign Het
Scrn1 A G 6: 54,522,754 (GRCm38) probably benign Het
Sdr42e1 T C 8: 117,663,443 (GRCm38) Y153C probably damaging Het
Slc18a1 A T 8: 69,065,626 (GRCm38) S245R probably damaging Het
Tns1 T G 1: 73,953,509 (GRCm38) D670A probably damaging Het
Trim16 T A 11: 62,820,858 (GRCm38) D118E probably benign Het
Trpv1 A G 11: 73,238,443 (GRCm38) D62G probably benign Het
Tyr A G 7: 87,437,948 (GRCm38) L452P probably damaging Het
Ubr4 T C 4: 139,421,373 (GRCm38) C1723R probably damaging Het
Uqcrb G A 13: 66,901,395 (GRCm38) probably benign Het
Vax2 G T 6: 83,711,537 (GRCm38) V81L possibly damaging Het
Zan A G 5: 137,464,844 (GRCm38) V691A unknown Het
Zfp335 A G 2: 164,894,788 (GRCm38) S976P possibly damaging Het
Zfp384 C T 6: 125,024,132 (GRCm38) P56S probably damaging Het
Other mutations in Naip5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00096:Naip5 APN 13 100,246,175 (GRCm38) nonsense probably null
IGL00493:Naip5 APN 13 100,230,771 (GRCm38) missense probably damaging 0.96
IGL01294:Naip5 APN 13 100,217,080 (GRCm38) missense probably damaging 0.99
IGL01405:Naip5 APN 13 100,221,945 (GRCm38) missense probably benign 0.11
IGL01804:Naip5 APN 13 100,221,584 (GRCm38) missense probably damaging 1.00
IGL02012:Naip5 APN 13 100,223,339 (GRCm38) missense probably benign 0.01
IGL02183:Naip5 APN 13 100,221,642 (GRCm38) missense probably benign 0.41
IGL02449:Naip5 APN 13 100,222,175 (GRCm38) missense probably benign 0.34
IGL02815:Naip5 APN 13 100,222,731 (GRCm38) missense probably benign
IGL02992:Naip5 APN 13 100,223,028 (GRCm38) missense probably damaging 1.00
IGL03027:Naip5 APN 13 100,223,016 (GRCm38) missense probably benign 0.00
IGL03234:Naip5 APN 13 100,212,627 (GRCm38) missense probably damaging 1.00
inwood2 UTSW 13 100,223,014 (GRCm38) nonsense probably null
inwood3 UTSW 13 100,221,903 (GRCm38) nonsense probably null
Nuchal UTSW 13 100,214,663 (GRCm38) missense possibly damaging 0.82
PIT4131001:Naip5 UTSW 13 100,219,760 (GRCm38) missense probably benign 0.00
PIT4131001:Naip5 UTSW 13 100,219,739 (GRCm38) missense probably benign
R0001:Naip5 UTSW 13 100,223,114 (GRCm38) missense probably benign
R0001:Naip5 UTSW 13 100,214,650 (GRCm38) critical splice donor site probably null
R0462:Naip5 UTSW 13 100,221,732 (GRCm38) missense probably damaging 1.00
R0636:Naip5 UTSW 13 100,219,688 (GRCm38) missense probably benign
R0674:Naip5 UTSW 13 100,223,199 (GRCm38) missense probably benign 0.04
R0764:Naip5 UTSW 13 100,217,105 (GRCm38) missense probably benign 0.03
R0837:Naip5 UTSW 13 100,230,743 (GRCm38) missense probably benign
R1179:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R1302:Naip5 UTSW 13 100,221,591 (GRCm38) missense possibly damaging 0.91
R1441:Naip5 UTSW 13 100,219,717 (GRCm38) missense possibly damaging 0.95
R1513:Naip5 UTSW 13 100,222,206 (GRCm38) missense probably benign
R1638:Naip5 UTSW 13 100,212,669 (GRCm38) missense probably damaging 1.00
R1651:Naip5 UTSW 13 100,221,911 (GRCm38) missense probably benign 0.41
R1707:Naip5 UTSW 13 100,242,855 (GRCm38) missense probably damaging 1.00
R1835:Naip5 UTSW 13 100,223,218 (GRCm38) nonsense probably null
R1836:Naip5 UTSW 13 100,219,687 (GRCm38) missense probably benign 0.18
R1972:Naip5 UTSW 13 100,212,770 (GRCm38) missense probably damaging 0.98
R2080:Naip5 UTSW 13 100,221,533 (GRCm38) missense probably damaging 1.00
R2333:Naip5 UTSW 13 100,223,171 (GRCm38) missense probably damaging 1.00
R2348:Naip5 UTSW 13 100,219,738 (GRCm38) missense probably benign 0.01
R3055:Naip5 UTSW 13 100,221,878 (GRCm38) missense probably benign 0.23
R3401:Naip5 UTSW 13 100,221,903 (GRCm38) nonsense probably null
R3723:Naip5 UTSW 13 100,223,014 (GRCm38) nonsense probably null
R3775:Naip5 UTSW 13 100,223,375 (GRCm38) missense probably benign 0.00
R3775:Naip5 UTSW 13 100,223,394 (GRCm38) missense probably benign 0.00
R4019:Naip5 UTSW 13 100,223,375 (GRCm38) missense probably benign 0.00
R4019:Naip5 UTSW 13 100,223,394 (GRCm38) missense probably benign 0.00
R4020:Naip5 UTSW 13 100,223,394 (GRCm38) missense probably benign 0.00
R4020:Naip5 UTSW 13 100,223,375 (GRCm38) missense probably benign 0.00
R4074:Naip5 UTSW 13 100,246,064 (GRCm38) missense probably damaging 1.00
R4082:Naip5 UTSW 13 100,245,830 (GRCm38) missense probably damaging 1.00
R4105:Naip5 UTSW 13 100,219,739 (GRCm38) missense probably benign
R4227:Naip5 UTSW 13 100,212,768 (GRCm38) missense probably damaging 0.99
R4639:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4640:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4641:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4644:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4645:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4700:Naip5 UTSW 13 100,223,414 (GRCm38) missense possibly damaging 0.62
R4727:Naip5 UTSW 13 100,221,870 (GRCm38) missense possibly damaging 0.81
R4729:Naip5 UTSW 13 100,222,131 (GRCm38) missense possibly damaging 0.75
R4816:Naip5 UTSW 13 100,219,681 (GRCm38) missense probably benign 0.32
R4816:Naip5 UTSW 13 100,219,687 (GRCm38) missense probably benign 0.01
R4816:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R4869:Naip5 UTSW 13 100,245,131 (GRCm38) missense probably damaging 1.00
R5162:Naip5 UTSW 13 100,223,406 (GRCm38) missense possibly damaging 0.78
R5244:Naip5 UTSW 13 100,245,662 (GRCm38) missense probably benign 0.08
R5411:Naip5 UTSW 13 100,245,746 (GRCm38) missense possibly damaging 0.54
R5632:Naip5 UTSW 13 100,230,662 (GRCm38) splice site probably null
R5760:Naip5 UTSW 13 100,242,838 (GRCm38) missense probably damaging 1.00
R5916:Naip5 UTSW 13 100,222,701 (GRCm38) missense probably benign 0.02
R6302:Naip5 UTSW 13 100,223,166 (GRCm38) missense possibly damaging 0.76
R6304:Naip5 UTSW 13 100,223,166 (GRCm38) missense possibly damaging 0.76
R6411:Naip5 UTSW 13 100,223,405 (GRCm38) missense probably benign 0.01
R6474:Naip5 UTSW 13 100,214,663 (GRCm38) missense possibly damaging 0.82
R6499:Naip5 UTSW 13 100,221,594 (GRCm38) missense probably benign
R6544:Naip5 UTSW 13 100,223,144 (GRCm38) missense possibly damaging 0.50
R6827:Naip5 UTSW 13 100,245,929 (GRCm38) missense possibly damaging 0.48
R6954:Naip5 UTSW 13 100,223,414 (GRCm38) missense probably damaging 0.99
R7052:Naip5 UTSW 13 100,222,347 (GRCm38) missense probably benign 0.01
R7138:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R7141:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R7375:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7375:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7401:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7401:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7447:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7447:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7466:Naip5 UTSW 13 100,221,986 (GRCm38) nonsense probably null
R7491:Naip5 UTSW 13 100,217,071 (GRCm38) missense probably benign 0.18
R7559:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7559:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7562:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7562:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7588:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7588:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7589:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7589:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7590:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7590:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7742:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R7886:Naip5 UTSW 13 100,246,181 (GRCm38) missense probably benign 0.28
R7996:Naip5 UTSW 13 100,221,656 (GRCm38) missense probably damaging 1.00
R8026:Naip5 UTSW 13 100,245,898 (GRCm38) missense probably damaging 1.00
R8046:Naip5 UTSW 13 100,222,233 (GRCm38) missense probably benign
R8319:Naip5 UTSW 13 100,221,659 (GRCm38) missense probably benign 0.12
R8471:Naip5 UTSW 13 100,221,645 (GRCm38) missense probably damaging 0.99
R8480:Naip5 UTSW 13 100,222,235 (GRCm38) missense probably damaging 1.00
R8496:Naip5 UTSW 13 100,212,739 (GRCm38) missense probably benign 0.00
R8500:Naip5 UTSW 13 100,222,712 (GRCm38) missense probably damaging 0.98
R8712:Naip5 UTSW 13 100,223,096 (GRCm38) missense possibly damaging 0.61
R8780:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8781:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8788:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8817:Naip5 UTSW 13 100,212,699 (GRCm38) missense probably benign 0.01
R8833:Naip5 UTSW 13 100,222,934 (GRCm38) missense probably damaging 0.97
R8835:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8958:Naip5 UTSW 13 100,217,609 (GRCm38) nonsense probably null
R9031:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9032:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9074:Naip5 UTSW 13 100,221,756 (GRCm38) missense possibly damaging 0.92
R9098:Naip5 UTSW 13 100,229,619 (GRCm38) missense possibly damaging 0.67
R9204:Naip5 UTSW 13 100,222,500 (GRCm38) missense probably damaging 1.00
R9223:Naip5 UTSW 13 100,227,676 (GRCm38) missense probably benign 0.05
R9358:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9389:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9403:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9518:Naip5 UTSW 13 100,221,859 (GRCm38) missense probably benign
R9568:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9568:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9569:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9569:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9570:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9572:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9581:Naip5 UTSW 13 100,214,686 (GRCm38) missense probably benign 0.11
R9627:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9725:Naip5 UTSW 13 100,222,276 (GRCm38) missense possibly damaging 0.94
R9763:Naip5 UTSW 13 100,230,761 (GRCm38) missense probably damaging 0.99
R9764:Naip5 UTSW 13 100,230,761 (GRCm38) missense probably damaging 0.99
R9765:Naip5 UTSW 13 100,230,761 (GRCm38) missense probably damaging 0.99
Posted On 2013-12-09