Incidental Mutation 'IGL01568:Gpr153'
ID 91077
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr153
Ensembl Gene ENSMUSG00000042804
Gene Name G protein-coupled receptor 153
Synonyms 1110065N12Rik, PGR1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01568
Quality Score
Status
Chromosome 4
Chromosomal Location 152274232-152285337 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 152282368 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101276 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055754] [ENSMUST00000094438] [ENSMUST00000105650] [ENSMUST00000105651] [ENSMUST00000218045]
AlphaFold Q8K0Z9
Predicted Effect probably null
Transcript: ENSMUST00000055754
SMART Domains Protein: ENSMUSP00000052742
Gene: ENSMUSG00000042804

DomainStartEndE-ValueType
Pfam:7tm_1 24 298 1.2e-14 PFAM
low complexity region 501 518 N/A INTRINSIC
low complexity region 605 617 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000094438
SMART Domains Protein: ENSMUSP00000092006
Gene: ENSMUSG00000028946

DomainStartEndE-ValueType
HLH 1 55 3.83e-11 SMART
low complexity region 129 148 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105650
SMART Domains Protein: ENSMUSP00000101275
Gene: ENSMUSG00000042804

DomainStartEndE-ValueType
Pfam:7tm_1 24 297 5.4e-18 PFAM
low complexity region 478 495 N/A INTRINSIC
low complexity region 582 594 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105651
SMART Domains Protein: ENSMUSP00000101276
Gene: ENSMUSG00000042804

DomainStartEndE-ValueType
Pfam:7tm_1 24 297 5.3e-17 PFAM
low complexity region 501 518 N/A INTRINSIC
low complexity region 605 617 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144035
Predicted Effect probably benign
Transcript: ENSMUST00000218045
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921507P07Rik A G 6: 50,573,698 (GRCm38) probably benign Het
Akap13 T A 7: 75,608,522 (GRCm38) L298* probably null Het
Capn15 G T 17: 25,965,445 (GRCm38) R21S probably damaging Het
Cbs A G 17: 31,621,514 (GRCm38) L290P possibly damaging Het
Dnah5 T C 15: 28,229,652 (GRCm38) I144T probably benign Het
Dok4 T A 8: 94,866,802 (GRCm38) I119F probably benign Het
Dpp9 T C 17: 56,191,159 (GRCm38) N599S probably benign Het
Ep400 T C 5: 110,719,495 (GRCm38) T984A unknown Het
Fcrls T C 3: 87,256,679 (GRCm38) N381S probably damaging Het
Fhod3 A G 18: 25,120,162 (GRCm38) I1390V probably benign Het
Gabbr1 A G 17: 37,070,669 (GRCm38) Y775C probably damaging Het
Gimap9 A G 6: 48,677,616 (GRCm38) T46A probably benign Het
Gm3696 T C 14: 7,089,819 (GRCm38) N88S probably benign Het
Gm5277 A G 3: 78,892,436 (GRCm38) noncoding transcript Het
Hgf A T 5: 16,564,814 (GRCm38) K95N probably damaging Het
Igf2r A G 17: 12,683,985 (GRCm38) S2393P possibly damaging Het
Ikbke C A 1: 131,257,896 (GRCm38) probably null Het
Il17re G T 6: 113,470,052 (GRCm38) R588L probably damaging Het
Itch T C 2: 155,212,462 (GRCm38) probably benign Het
Krt2 T A 15: 101,813,211 (GRCm38) D465V probably damaging Het
Krt28 G T 11: 99,371,417 (GRCm38) P249Q probably damaging Het
Lax1 A T 1: 133,680,300 (GRCm38) D234E probably benign Het
Mtmr3 A G 11: 4,527,861 (GRCm38) I61T probably damaging Het
Naip5 G T 13: 100,217,101 (GRCm38) Q1217K probably benign Het
Nt5dc3 A G 10: 86,833,938 (GRCm38) T466A probably benign Het
Olfr1350 A T 7: 6,570,570 (GRCm38) H193L possibly damaging Het
Olfr283 T C 15: 98,378,906 (GRCm38) D68G probably damaging Het
Pcdhb3 T C 18: 37,302,001 (GRCm38) V340A possibly damaging Het
Pclo C T 5: 14,678,429 (GRCm38) probably benign Het
Piezo2 C T 18: 63,030,392 (GRCm38) V2152I probably benign Het
Pip4k2b A T 11: 97,729,552 (GRCm38) probably null Het
Ptprs G A 17: 56,413,958 (GRCm38) H1432Y probably damaging Het
Rars A G 11: 35,825,981 (GRCm38) probably benign Het
Scrn1 A G 6: 54,522,754 (GRCm38) probably benign Het
Sdr42e1 T C 8: 117,663,443 (GRCm38) Y153C probably damaging Het
Slc18a1 A T 8: 69,065,626 (GRCm38) S245R probably damaging Het
Tns1 T G 1: 73,953,509 (GRCm38) D670A probably damaging Het
Trim16 T A 11: 62,820,858 (GRCm38) D118E probably benign Het
Trpv1 A G 11: 73,238,443 (GRCm38) D62G probably benign Het
Tyr A G 7: 87,437,948 (GRCm38) L452P probably damaging Het
Ubr4 T C 4: 139,421,373 (GRCm38) C1723R probably damaging Het
Uqcrb G A 13: 66,901,395 (GRCm38) probably benign Het
Vax2 G T 6: 83,711,537 (GRCm38) V81L possibly damaging Het
Zan A G 5: 137,464,844 (GRCm38) V691A unknown Het
Zfp335 A G 2: 164,894,788 (GRCm38) S976P possibly damaging Het
Zfp384 C T 6: 125,024,132 (GRCm38) P56S probably damaging Het
Other mutations in Gpr153
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Gpr153 APN 4 152,281,966 (GRCm38) unclassified probably benign
IGL01368:Gpr153 APN 4 152,282,994 (GRCm38) missense probably benign 0.40
IGL01672:Gpr153 APN 4 152,279,913 (GRCm38) nonsense probably null
R0735:Gpr153 UTSW 4 152,279,373 (GRCm38) nonsense probably null
R0925:Gpr153 UTSW 4 152,281,874 (GRCm38) missense probably benign
R1302:Gpr153 UTSW 4 152,279,943 (GRCm38) missense probably damaging 1.00
R1829:Gpr153 UTSW 4 152,282,392 (GRCm38) missense possibly damaging 0.70
R2041:Gpr153 UTSW 4 152,283,353 (GRCm38) missense probably benign
R4698:Gpr153 UTSW 4 152,281,783 (GRCm38) missense probably damaging 1.00
R5069:Gpr153 UTSW 4 152,279,883 (GRCm38) missense probably damaging 0.99
R5623:Gpr153 UTSW 4 152,281,941 (GRCm38) missense possibly damaging 0.89
R5800:Gpr153 UTSW 4 152,280,077 (GRCm38) nonsense probably null
R5940:Gpr153 UTSW 4 152,283,375 (GRCm38) missense probably benign 0.12
R6773:Gpr153 UTSW 4 152,279,300 (GRCm38) missense probably damaging 1.00
R6944:Gpr153 UTSW 4 152,279,363 (GRCm38) missense probably damaging 1.00
R7486:Gpr153 UTSW 4 152,282,401 (GRCm38) missense probably benign 0.01
R8170:Gpr153 UTSW 4 152,280,177 (GRCm38) missense probably damaging 1.00
R8699:Gpr153 UTSW 4 152,279,101 (GRCm38) start gained probably benign
R8701:Gpr153 UTSW 4 152,279,101 (GRCm38) start gained probably benign
R8732:Gpr153 UTSW 4 152,279,101 (GRCm38) start gained probably benign
R9047:Gpr153 UTSW 4 152,280,207 (GRCm38) missense probably damaging 1.00
R9383:Gpr153 UTSW 4 152,283,059 (GRCm38) missense probably benign
Posted On 2013-12-09