Incidental Mutation 'IGL01569:Vmn1r89'
| ID |
91080 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r89
|
| Ensembl Gene |
ENSMUSG00000095629 |
| Gene Name |
vomeronasal 1 receptor 89 |
| Synonyms |
V1rj2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.121)
|
| Stock # |
IGL01569
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
12953266-12954216 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 12953432 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 56
(M56T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154359
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053008]
[ENSMUST00000226717]
[ENSMUST00000227176]
[ENSMUST00000227239]
[ENSMUST00000227276]
[ENSMUST00000227319]
[ENSMUST00000227390]
[ENSMUST00000228587]
|
| AlphaFold |
Q8R256 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053008
AA Change: M56T
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000096413
Gene: ENSMUSG00000095629
AA Change: M56T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
306 |
1.9e-15 |
PFAM |
|
Pfam:7tm_1
|
25 |
295 |
1.1e-6 |
PFAM |
|
Pfam:V1R
|
36 |
301 |
1.5e-34 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226717
AA Change: M56T
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227176
AA Change: M56T
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227239
AA Change: M56T
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227276
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227319
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227390
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228587
AA Change: M56T
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228795
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228825
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
C |
17: 9,215,827 (GRCm39) |
V311A |
probably benign |
Het |
| Bdh1 |
T |
C |
16: 31,273,909 (GRCm39) |
M194T |
probably benign |
Het |
| Dnmbp |
T |
C |
19: 43,863,295 (GRCm39) |
R808G |
probably benign |
Het |
| Esco2 |
T |
C |
14: 66,063,977 (GRCm39) |
I402M |
probably benign |
Het |
| Gm5422 |
T |
C |
10: 31,125,897 (GRCm39) |
|
noncoding transcript |
Het |
| Il5ra |
C |
A |
6: 106,708,794 (GRCm39) |
M1I |
probably null |
Het |
| Kcnk4 |
T |
A |
19: 6,904,545 (GRCm39) |
I240F |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,897,523 (GRCm39) |
E698G |
probably damaging |
Het |
| Mkln1 |
A |
G |
6: 31,405,063 (GRCm39) |
|
probably benign |
Het |
| Mypn |
C |
T |
10: 62,963,538 (GRCm39) |
G978R |
probably damaging |
Het |
| Or2m12 |
T |
C |
16: 19,105,410 (GRCm39) |
T28A |
probably benign |
Het |
| Podn |
T |
A |
4: 107,881,496 (GRCm39) |
Y6F |
probably damaging |
Het |
| Psmg2 |
G |
A |
18: 67,786,293 (GRCm39) |
V218I |
probably benign |
Het |
| Rad54l |
T |
C |
4: 115,956,195 (GRCm39) |
D544G |
probably damaging |
Het |
| Reck |
C |
A |
4: 43,925,172 (GRCm39) |
S470R |
probably benign |
Het |
| Sik3 |
A |
G |
9: 46,123,024 (GRCm39) |
H891R |
probably benign |
Het |
| Tbata |
C |
T |
10: 61,011,739 (GRCm39) |
R92* |
probably null |
Het |
| Tdrd1 |
A |
G |
19: 56,822,841 (GRCm39) |
N103S |
probably damaging |
Het |
| Timm21 |
A |
G |
18: 84,969,400 (GRCm39) |
V8A |
probably benign |
Het |
| Tnn |
A |
G |
1: 159,948,124 (GRCm39) |
V863A |
possibly damaging |
Het |
| Togaram1 |
A |
G |
12: 65,029,436 (GRCm39) |
D953G |
possibly damaging |
Het |
| Tpm1 |
T |
C |
9: 66,938,390 (GRCm39) |
|
probably null |
Het |
| Trgv4 |
A |
G |
13: 19,369,678 (GRCm39) |
|
probably benign |
Het |
| Vmn1r8 |
A |
T |
6: 57,013,272 (GRCm39) |
N108Y |
possibly damaging |
Het |
| Ythdc2 |
A |
G |
18: 45,020,718 (GRCm39) |
E1434G |
probably benign |
Het |
|
| Other mutations in Vmn1r89 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02085:Vmn1r89
|
APN |
7 |
12,953,465 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02694:Vmn1r89
|
APN |
7 |
12,954,056 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02709:Vmn1r89
|
APN |
7 |
12,954,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4142001:Vmn1r89
|
UTSW |
7 |
12,953,515 (GRCm39) |
missense |
probably benign |
|
|
R0765:Vmn1r89
|
UTSW |
7 |
12,953,467 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1396:Vmn1r89
|
UTSW |
7 |
12,953,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn1r89
|
UTSW |
7 |
12,954,187 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4296:Vmn1r89
|
UTSW |
7 |
12,954,113 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4472:Vmn1r89
|
UTSW |
7 |
12,953,799 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5037:Vmn1r89
|
UTSW |
7 |
12,953,314 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5267:Vmn1r89
|
UTSW |
7 |
12,954,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Vmn1r89
|
UTSW |
7 |
12,953,284 (GRCm39) |
missense |
probably benign |
|
|
R5455:Vmn1r89
|
UTSW |
7 |
12,954,194 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5595:Vmn1r89
|
UTSW |
7 |
12,953,857 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5643:Vmn1r89
|
UTSW |
7 |
12,954,146 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7493:Vmn1r89
|
UTSW |
7 |
12,953,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation