Incidental Mutation 'IGL01569:Olfr164'
ID91087
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr164
Ensembl Gene ENSMUSG00000050742
Gene Nameolfactory receptor 164
SynonymsGA_x54KRFPKG5P-15738260-15737319, MOR279-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL01569
Quality Score
Status
Chromosome16
Chromosomal Location19284104-19314064 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 19286660 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 28 (T28A)
Ref Sequence ENSEMBL: ENSMUSP00000149971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056727] [ENSMUST00000216157]
Predicted Effect probably benign
Transcript: ENSMUST00000056727
AA Change: T28A

PolyPhen 2 Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000056970
Gene: ENSMUSG00000050742
AA Change: T28A

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 2.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 38 308 8.2e-8 PFAM
Pfam:7tm_1 44 293 5.9e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216157
AA Change: T28A

PolyPhen 2 Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T C 17: 8,996,995 V311A probably benign Het
Bdh1 T C 16: 31,455,091 M194T probably benign Het
Dnmbp T C 19: 43,874,856 R808G probably benign Het
Esco2 T C 14: 65,826,528 I402M probably benign Het
Gm5422 T C 10: 31,249,901 noncoding transcript Het
Il5ra C A 6: 106,731,833 M1I probably null Het
Kcnk4 T A 19: 6,927,177 I240F probably damaging Het
Mast4 T C 13: 102,761,015 E698G probably damaging Het
Mkln1 A G 6: 31,428,128 probably benign Het
Mypn C T 10: 63,127,759 G978R probably damaging Het
Podn T A 4: 108,024,299 Y6F probably damaging Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Rad54l T C 4: 116,098,998 D544G probably damaging Het
Reck C A 4: 43,925,172 S470R probably benign Het
Sik3 A G 9: 46,211,726 H891R probably benign Het
Tbata C T 10: 61,175,960 R92* probably null Het
Tcrg-V4 A G 13: 19,185,508 probably benign Het
Tdrd1 A G 19: 56,834,409 N103S probably damaging Het
Timm21 A G 18: 84,951,275 V8A probably benign Het
Tnn A G 1: 160,120,554 V863A possibly damaging Het
Togaram1 A G 12: 64,982,662 D953G possibly damaging Het
Tpm1 T C 9: 67,031,108 probably null Het
Vmn1r8 A T 6: 57,036,287 N108Y possibly damaging Het
Vmn1r89 T C 7: 13,219,505 M56T probably benign Het
Ythdc2 A G 18: 44,887,651 E1434G probably benign Het
Other mutations in Olfr164
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01529:Olfr164 APN 16 19286700 missense probably benign 0.01
IGL01619:Olfr164 APN 16 19286159 missense probably damaging 1.00
IGL02101:Olfr164 APN 16 19286613 missense probably benign
IGL02201:Olfr164 APN 16 19286462 missense probably benign 0.03
IGL02730:Olfr164 APN 16 19286682 missense probably benign 0.00
IGL03228:Olfr164 APN 16 19286390 missense probably damaging 1.00
R1566:Olfr164 UTSW 16 19286327 missense possibly damaging 0.76
R1817:Olfr164 UTSW 16 19285877 missense probably damaging 1.00
R1870:Olfr164 UTSW 16 19286607 missense probably damaging 1.00
R1918:Olfr164 UTSW 16 19286302 missense probably benign 0.03
R2202:Olfr164 UTSW 16 19286297 missense probably benign 0.03
R2265:Olfr164 UTSW 16 19286555 missense probably damaging 1.00
R3792:Olfr164 UTSW 16 19285946 missense possibly damaging 0.54
R4285:Olfr164 UTSW 16 19285964 missense probably damaging 1.00
R4961:Olfr164 UTSW 16 19285976 missense probably damaging 1.00
R5022:Olfr164 UTSW 16 19286059 missense probably damaging 1.00
R5432:Olfr164 UTSW 16 19286089 missense probably benign 0.06
R5827:Olfr164 UTSW 16 19286432 missense probably benign 0.24
R6154:Olfr164 UTSW 16 19286431 missense probably damaging 0.99
R6188:Olfr164 UTSW 16 19286557 missense probably damaging 1.00
R6367:Olfr164 UTSW 16 19286072 missense probably damaging 1.00
Posted On2013-12-09