Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01572:Styxl2'

91134

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Styxl2

Ensembl Gene

ENSMUSG00000026564

Gene Name

serine/threonine/tyrosine interacting like 2

Synonyms

C130085G02Rik, Dusp27

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01572

Quality Score

Status

Chromosome

Chromosomal Location

165925717-165955467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 165927941 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Glutamic Acid at position 557 (A557E)

Ref Sequence

ENSEMBL: ENSMUSP00000141564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085992] [ENSMUST00000192369]

AlphaFold

Q148W8

Predicted Effect

probably benign
Transcript: ENSMUST00000085992
AA Change: A557E

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000083155
Gene: ENSMUSG00000026564
AA Change: A557E

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192369
AA Change: A557E

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000141564
Gene: ENSMUSG00000026564
AA Change: A557E

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp8a1	A	G	5: 67,824,994 (GRCm39)	V779A	probably benign	Het
Atrn	T	C	2: 130,844,715 (GRCm39)	S1199P	probably damaging	Het
BC051076	C	A	5: 88,112,549 (GRCm39)		probably benign	Het
Cdh17	T	C	4: 11,784,621 (GRCm39)		probably benign	Het
Ceacam20	T	C	7: 19,708,199 (GRCm39)	V268A	probably damaging	Het
Cntn2	T	G	1: 132,455,909 (GRCm39)	D203A	probably damaging	Het
Cped1	A	G	6: 22,051,300 (GRCm39)	N148D	probably benign	Het
Dnah10	T	A	5: 124,861,010 (GRCm39)	V2131E	probably damaging	Het
Dsn1	A	G	2: 156,841,054 (GRCm39)		probably null	Het
Eif5b	A	T	1: 38,061,335 (GRCm39)	K409*	probably null	Het
Fam237b	T	A	5: 5,625,475 (GRCm39)	I57K	probably damaging	Het
Gaa	T	C	11: 119,175,003 (GRCm39)	V868A	probably benign	Het
Igf1r	A	G	7: 67,843,189 (GRCm39)	T767A	probably benign	Het
Ints7	T	A	1: 191,347,905 (GRCm39)	V759E	possibly damaging	Het
Jarid2	A	G	13: 45,038,311 (GRCm39)	T171A	probably damaging	Het
Krt33b	T	C	11: 99,917,378 (GRCm39)	D158G	probably damaging	Het
Krt87	T	C	15: 101,334,414 (GRCm39)	R198G	probably benign	Het
Mst1r	C	A	9: 107,788,791 (GRCm39)	R437S	probably damaging	Het
Myh15	T	A	16: 48,920,585 (GRCm39)	I458K	possibly damaging	Het
Or8k37	T	C	2: 86,469,283 (GRCm39)	I256M	possibly damaging	Het
Scn9a	A	T	2: 66,324,230 (GRCm39)	N1418K	probably benign	Het
Sppl2a	A	G	2: 126,762,232 (GRCm39)		probably null	Het
Zfp595	A	T	13: 67,465,465 (GRCm39)	I266K	possibly damaging	Het

Other mutations in Styxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00706:Styxl2	APN	1	165,928,121 (GRCm39)	missense	probably benign	0.00
IGL00973:Styxl2	APN	1	165,927,027 (GRCm39)	missense	probably benign
IGL01331:Styxl2	APN	1	165,935,749 (GRCm39)	missense	probably damaging	1.00
IGL01466:Styxl2	APN	1	165,928,073 (GRCm39)	missense	probably damaging	1.00
IGL01906:Styxl2	APN	1	165,927,092 (GRCm39)	missense	probably damaging	1.00
IGL01974:Styxl2	APN	1	165,928,105 (GRCm39)	nonsense	probably null
IGL02112:Styxl2	APN	1	165,927,240 (GRCm39)	nonsense	probably null
IGL02805:Styxl2	APN	1	165,926,630 (GRCm39)	missense	probably damaging	1.00
IGL03343:Styxl2	APN	1	165,927,017 (GRCm39)	missense	probably benign	0.00
R0116:Styxl2	UTSW	1	165,927,270 (GRCm39)	missense	probably benign	0.19
R0367:Styxl2	UTSW	1	165,928,332 (GRCm39)	missense	probably benign	0.05
R0499:Styxl2	UTSW	1	165,926,670 (GRCm39)	missense	probably benign	0.00
R0542:Styxl2	UTSW	1	165,928,853 (GRCm39)	missense	possibly damaging	0.90
R1312:Styxl2	UTSW	1	165,926,860 (GRCm39)	missense	possibly damaging	0.46
R1572:Styxl2	UTSW	1	165,927,024 (GRCm39)	missense	possibly damaging	0.68
R1598:Styxl2	UTSW	1	165,937,828 (GRCm39)	missense	probably benign	0.10
R1858:Styxl2	UTSW	1	165,928,415 (GRCm39)	missense	possibly damaging	0.87
R2021:Styxl2	UTSW	1	165,928,392 (GRCm39)	missense	probably benign	0.00
R2970:Styxl2	UTSW	1	165,926,798 (GRCm39)	missense	probably benign	0.04
R3727:Styxl2	UTSW	1	165,927,075 (GRCm39)	missense	probably damaging	1.00
R4041:Styxl2	UTSW	1	165,927,680 (GRCm39)	missense	probably benign	0.01
R4245:Styxl2	UTSW	1	165,928,685 (GRCm39)	missense	probably damaging	1.00
R4955:Styxl2	UTSW	1	165,935,661 (GRCm39)	missense	probably damaging	1.00
R4967:Styxl2	UTSW	1	165,954,675 (GRCm39)	missense	probably damaging	1.00
R5040:Styxl2	UTSW	1	165,927,914 (GRCm39)	missense	probably benign	0.17
R5342:Styxl2	UTSW	1	165,937,819 (GRCm39)	missense	probably benign	0.01
R5467:Styxl2	UTSW	1	165,939,599 (GRCm39)	critical splice donor site	probably null
R5742:Styxl2	UTSW	1	165,927,023 (GRCm39)	missense	probably benign	0.00
R6222:Styxl2	UTSW	1	165,926,214 (GRCm39)	missense	probably benign	0.26
R6239:Styxl2	UTSW	1	165,926,388 (GRCm39)	missense	probably damaging	1.00
R6531:Styxl2	UTSW	1	165,937,615 (GRCm39)	splice site	probably null
R6586:Styxl2	UTSW	1	165,928,454 (GRCm39)	missense	possibly damaging	0.79
R6958:Styxl2	UTSW	1	165,935,565 (GRCm39)	missense	probably damaging	1.00
R7006:Styxl2	UTSW	1	165,926,663 (GRCm39)	missense	probably benign
R7111:Styxl2	UTSW	1	165,954,723 (GRCm39)	missense	possibly damaging	0.66
R7310:Styxl2	UTSW	1	165,926,300 (GRCm39)	missense	possibly damaging	0.46
R7312:Styxl2	UTSW	1	165,954,676 (GRCm39)	missense	probably damaging	0.99
R7378:Styxl2	UTSW	1	165,939,632 (GRCm39)	nonsense	probably null
R7398:Styxl2	UTSW	1	165,928,044 (GRCm39)	missense	probably damaging	1.00
R7442:Styxl2	UTSW	1	165,928,584 (GRCm39)	missense	probably benign	0.01
R7569:Styxl2	UTSW	1	165,935,604 (GRCm39)	missense	probably damaging	1.00
R7920:Styxl2	UTSW	1	165,927,465 (GRCm39)	missense	possibly damaging	0.72
R7954:Styxl2	UTSW	1	165,926,849 (GRCm39)	missense	probably benign	0.05
R7972:Styxl2	UTSW	1	165,926,708 (GRCm39)	missense	probably damaging	1.00
R8186:Styxl2	UTSW	1	165,927,648 (GRCm39)	missense	probably damaging	1.00
R8354:Styxl2	UTSW	1	165,935,702 (GRCm39)	missense	probably damaging	1.00
R8454:Styxl2	UTSW	1	165,935,702 (GRCm39)	missense	probably damaging	1.00
R8535:Styxl2	UTSW	1	165,928,730 (GRCm39)	missense	probably benign	0.01
R9419:Styxl2	UTSW	1	165,927,755 (GRCm39)	missense	probably damaging	1.00
R9493:Styxl2	UTSW	1	165,926,410 (GRCm39)	missense	probably damaging	1.00
R9694:Styxl2	UTSW	1	165,928,654 (GRCm39)	missense	probably damaging	1.00
Z1088:Styxl2	UTSW	1	165,926,852 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09