Incidental Mutation 'IGL01574:Vmn2r51'
ID 91177
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r51
Ensembl Gene ENSMUSG00000058685
Gene Name vomeronasal 2, receptor 51
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL01574
Quality Score
Status
Chromosome 7
Chromosomal Location 9821125-9839586 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 9836381 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 133 (E133D)
Ref Sequence ENSEMBL: ENSMUSP00000092459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094863]
AlphaFold L7N215
Predicted Effect probably damaging
Transcript: ENSMUST00000094863
AA Change: E133D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000092459
Gene: ENSMUSG00000058685
AA Change: E133D

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 2.4e-31 PFAM
Pfam:NCD3G 512 565 8.1e-21 PFAM
Pfam:7tm_3 598 833 2.7e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd26 T G 6: 118,516,659 (GRCm39) T502P probably damaging Het
Apoa4 C A 9: 46,154,283 (GRCm39) Q295K probably benign Het
Asxl3 T G 18: 22,656,621 (GRCm39) C1544G probably benign Het
Ccl7 G A 11: 81,937,451 (GRCm39) V62I probably damaging Het
Ceacam20 C A 7: 19,708,247 (GRCm39) T284K possibly damaging Het
Ces4a A T 8: 105,871,859 (GRCm39) probably benign Het
Col4a2 G T 8: 11,489,306 (GRCm39) G1147V probably damaging Het
Gtf3c4 T C 2: 28,724,448 (GRCm39) D428G possibly damaging Het
Itgb2 G A 10: 77,393,798 (GRCm39) V413I possibly damaging Het
Itgb7 T G 15: 102,135,975 (GRCm39) E20A possibly damaging Het
Kank2 C A 9: 21,705,900 (GRCm39) G373W probably damaging Het
Kif1a T A 1: 93,010,062 (GRCm39) I28F probably damaging Het
Klhdc7b T C 15: 89,271,572 (GRCm39) V818A probably benign Het
Klhl20 T C 1: 160,921,296 (GRCm39) Y53C probably damaging Het
Matcap2 T C 9: 22,355,426 (GRCm39) V487A possibly damaging Het
Mroh1 A G 15: 76,316,488 (GRCm39) N772S probably benign Het
Mtmr4 C T 11: 87,491,473 (GRCm39) T146I probably benign Het
Nup210 C T 6: 91,017,546 (GRCm39) V1152I probably benign Het
Pclo T A 5: 14,763,462 (GRCm39) D3978E unknown Het
Pkd1l3 T C 8: 110,350,403 (GRCm39) L416P probably benign Het
Pkn2 T C 3: 142,544,992 (GRCm39) M161V possibly damaging Het
Plxnb2 T C 15: 89,046,886 (GRCm39) probably null Het
Polr2e C A 10: 79,875,467 (GRCm39) D3Y probably damaging Het
Prss27 A T 17: 24,257,345 (GRCm39) probably benign Het
Psmg2 G A 18: 67,786,293 (GRCm39) V218I probably benign Het
Tmem30c T A 16: 57,097,105 (GRCm39) I152F possibly damaging Het
Usp2 G A 9: 44,005,100 (GRCm39) R378H probably damaging Het
Vmn2r106 A T 17: 20,488,572 (GRCm39) I609N possibly damaging Het
Zkscan3 A T 13: 21,578,261 (GRCm39) probably benign Het
Other mutations in Vmn2r51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01398:Vmn2r51 APN 7 9,836,341 (GRCm39) missense probably benign
IGL01743:Vmn2r51 APN 7 9,834,154 (GRCm39) missense probably damaging 0.98
IGL01820:Vmn2r51 APN 7 9,839,409 (GRCm39) missense probably damaging 1.00
IGL02563:Vmn2r51 APN 7 9,834,243 (GRCm39) missense probably benign 0.00
IGL02825:Vmn2r51 APN 7 9,832,046 (GRCm39) splice site probably benign
IGL02834:Vmn2r51 APN 7 9,832,063 (GRCm39) nonsense probably null
R0617:Vmn2r51 UTSW 7 9,834,396 (GRCm39) missense possibly damaging 0.65
R0967:Vmn2r51 UTSW 7 9,834,012 (GRCm39) missense probably damaging 0.97
R1465:Vmn2r51 UTSW 7 9,834,249 (GRCm39) missense probably damaging 1.00
R1465:Vmn2r51 UTSW 7 9,834,249 (GRCm39) missense probably damaging 1.00
R1559:Vmn2r51 UTSW 7 9,836,373 (GRCm39) missense possibly damaging 0.87
R1559:Vmn2r51 UTSW 7 9,836,372 (GRCm39) missense possibly damaging 0.58
R1598:Vmn2r51 UTSW 7 9,839,432 (GRCm39) missense probably benign
R1754:Vmn2r51 UTSW 7 9,833,873 (GRCm39) missense probably benign 0.04
R1836:Vmn2r51 UTSW 7 9,832,091 (GRCm39) nonsense probably null
R1836:Vmn2r51 UTSW 7 9,832,090 (GRCm39) nonsense probably null
R3151:Vmn2r51 UTSW 7 9,833,968 (GRCm39) missense probably damaging 1.00
R4566:Vmn2r51 UTSW 7 9,836,341 (GRCm39) missense probably benign
R4933:Vmn2r51 UTSW 7 9,832,247 (GRCm39) missense probably damaging 1.00
R5004:Vmn2r51 UTSW 7 9,821,932 (GRCm39) missense probably benign
R5050:Vmn2r51 UTSW 7 9,834,349 (GRCm39) missense probably damaging 0.99
R5510:Vmn2r51 UTSW 7 9,836,545 (GRCm39) missense possibly damaging 0.95
R5559:Vmn2r51 UTSW 7 9,826,128 (GRCm39) missense probably damaging 1.00
R6127:Vmn2r51 UTSW 7 9,839,558 (GRCm39) missense probably damaging 1.00
R6154:Vmn2r51 UTSW 7 9,821,921 (GRCm39) missense possibly damaging 0.74
R6304:Vmn2r51 UTSW 7 9,832,164 (GRCm39) missense probably benign 0.00
R6370:Vmn2r51 UTSW 7 9,832,143 (GRCm39) missense probably damaging 1.00
R6471:Vmn2r51 UTSW 7 9,836,510 (GRCm39) missense possibly damaging 0.48
R6800:Vmn2r51 UTSW 7 9,832,191 (GRCm39) missense probably damaging 0.99
R6883:Vmn2r51 UTSW 7 9,834,025 (GRCm39) missense possibly damaging 0.75
R7191:Vmn2r51 UTSW 7 9,834,480 (GRCm39) missense probably null 1.00
R7246:Vmn2r51 UTSW 7 9,836,428 (GRCm39) missense probably benign 0.00
R8939:Vmn2r51 UTSW 7 9,833,953 (GRCm39) missense possibly damaging 0.85
R9154:Vmn2r51 UTSW 7 9,839,480 (GRCm39) missense probably damaging 0.96
R9428:Vmn2r51 UTSW 7 9,833,712 (GRCm39) critical splice donor site probably benign
R9451:Vmn2r51 UTSW 7 9,833,816 (GRCm39) missense probably damaging 1.00
R9729:Vmn2r51 UTSW 7 9,839,479 (GRCm39) missense probably benign 0.00
R9767:Vmn2r51 UTSW 7 9,839,407 (GRCm39) missense probably benign 0.09
Z1176:Vmn2r51 UTSW 7 9,833,835 (GRCm39) missense probably benign 0.12
Z1176:Vmn2r51 UTSW 7 9,821,984 (GRCm39) missense possibly damaging 0.76
Posted On 2013-12-09