Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01574:Vmn2r51'

91177

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r51

Ensembl Gene

ENSMUSG00000058685

Gene Name

vomeronasal 2, receptor 51

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL01574

Quality Score

Status

Chromosome

Chromosomal Location

10087198-10105659 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 10102454 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 133 (E133D)

Ref Sequence

ENSEMBL: ENSMUSP00000092459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094863]

AlphaFold

L7N215

Predicted Effect

probably damaging
Transcript: ENSMUST00000094863
AA Change: E133D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000092459
Gene: ENSMUSG00000058685
AA Change: E133D

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.4e-31	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	2.7e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530077C05Rik	T	C	9: 22,444,130	V487A	possibly damaging	Het
Ankrd26	T	G	6: 118,539,698	T502P	probably damaging	Het
Apoa4	C	A	9: 46,242,985	Q295K	probably benign	Het
Asxl3	T	G	18: 22,523,564	C1544G	probably benign	Het
Ccl7	G	A	11: 82,046,625	V62I	probably damaging	Het
Ceacam20	C	A	7: 19,974,322	T284K	possibly damaging	Het
Ces4a	A	T	8: 105,145,227		probably benign	Het
Col4a2	G	T	8: 11,439,306	G1147V	probably damaging	Het
Gtf3c4	T	C	2: 28,834,436	D428G	possibly damaging	Het
Itgb2	G	A	10: 77,557,964	V413I	possibly damaging	Het
Itgb7	T	G	15: 102,227,540	E20A	possibly damaging	Het
Kank2	C	A	9: 21,794,604	G373W	probably damaging	Het
Kif1a	T	A	1: 93,082,340	I28F	probably damaging	Het
Klhdc7b	T	C	15: 89,387,369	V818A	probably benign	Het
Klhl20	T	C	1: 161,093,726	Y53C	probably damaging	Het
Mroh1	A	G	15: 76,432,288	N772S	probably benign	Het
Mtmr4	C	T	11: 87,600,647	T146I	probably benign	Het
Nup210	C	T	6: 91,040,564	V1152I	probably benign	Het
Pclo	T	A	5: 14,713,448	D3978E	unknown	Het
Pkd1l3	T	C	8: 109,623,771	L416P	probably benign	Het
Pkn2	T	C	3: 142,839,231	M161V	possibly damaging	Het
Plxnb2	T	C	15: 89,162,683		probably null	Het
Polr2e	C	A	10: 80,039,633	D3Y	probably damaging	Het
Prss27	A	T	17: 24,038,371		probably benign	Het
Psmg2	G	A	18: 67,653,223	V218I	probably benign	Het
Tmem30c	T	A	16: 57,276,742	I152F	possibly damaging	Het
Usp2	G	A	9: 44,093,803	R378H	probably damaging	Het
Vmn2r106	A	T	17: 20,268,310	I609N	possibly damaging	Het
Zkscan3	A	T	13: 21,394,091		probably benign	Het

Other mutations in Vmn2r51

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01398:Vmn2r51	APN	7	10102414	missense	probably benign
IGL01743:Vmn2r51	APN	7	10100227	missense	probably damaging	0.98
IGL01820:Vmn2r51	APN	7	10105482	missense	probably damaging	1.00
IGL02563:Vmn2r51	APN	7	10100316	missense	probably benign	0.00
IGL02825:Vmn2r51	APN	7	10098119	splice site	probably benign
IGL02834:Vmn2r51	APN	7	10098136	nonsense	probably null
R0617:Vmn2r51	UTSW	7	10100469	missense	possibly damaging	0.65
R0967:Vmn2r51	UTSW	7	10100085	missense	probably damaging	0.97
R1465:Vmn2r51	UTSW	7	10100322	missense	probably damaging	1.00
R1465:Vmn2r51	UTSW	7	10100322	missense	probably damaging	1.00
R1559:Vmn2r51	UTSW	7	10102445	missense	possibly damaging	0.58
R1559:Vmn2r51	UTSW	7	10102446	missense	possibly damaging	0.87
R1598:Vmn2r51	UTSW	7	10105505	missense	probably benign
R1754:Vmn2r51	UTSW	7	10099946	missense	probably benign	0.04
R1836:Vmn2r51	UTSW	7	10098163	nonsense	probably null
R1836:Vmn2r51	UTSW	7	10098164	nonsense	probably null
R3151:Vmn2r51	UTSW	7	10100041	missense	probably damaging	1.00
R4566:Vmn2r51	UTSW	7	10102414	missense	probably benign
R4933:Vmn2r51	UTSW	7	10098320	missense	probably damaging	1.00
R5004:Vmn2r51	UTSW	7	10088005	missense	probably benign
R5050:Vmn2r51	UTSW	7	10100422	missense	probably damaging	0.99
R5510:Vmn2r51	UTSW	7	10102618	missense	possibly damaging	0.95
R5559:Vmn2r51	UTSW	7	10092201	missense	probably damaging	1.00
R6127:Vmn2r51	UTSW	7	10105631	missense	probably damaging	1.00
R6154:Vmn2r51	UTSW	7	10087994	missense	possibly damaging	0.74
R6304:Vmn2r51	UTSW	7	10098237	missense	probably benign	0.00
R6370:Vmn2r51	UTSW	7	10098216	missense	probably damaging	1.00
R6471:Vmn2r51	UTSW	7	10102583	missense	possibly damaging	0.48
R6800:Vmn2r51	UTSW	7	10098264	missense	probably damaging	0.99
R6883:Vmn2r51	UTSW	7	10100098	missense	possibly damaging	0.75
R7191:Vmn2r51	UTSW	7	10100553	missense	probably null	1.00
R7246:Vmn2r51	UTSW	7	10102501	missense	probably benign	0.00
R8939:Vmn2r51	UTSW	7	10100026	missense	possibly damaging	0.85
R9154:Vmn2r51	UTSW	7	10105553	missense	probably damaging	0.96
R9428:Vmn2r51	UTSW	7	10099785	critical splice donor site	probably benign
R9451:Vmn2r51	UTSW	7	10099889	missense	probably damaging	1.00
R9729:Vmn2r51	UTSW	7	10105552	missense	probably benign	0.00
R9767:Vmn2r51	UTSW	7	10105480	missense	probably benign	0.09
Z1176:Vmn2r51	UTSW	7	10088057	missense	possibly damaging	0.76
Z1176:Vmn2r51	UTSW	7	10099908	missense	probably benign	0.12

Posted On

2013-12-09