Incidental Mutation 'IGL01574:Ccl7'
ID91194
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccl7
Ensembl Gene ENSMUSG00000035373
Gene Namechemokine (C-C motif) ligand 7
Synonymsmarc, mcp3, Scya7, fic, MCP-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL01574
Quality Score
Status
Chromosome11
Chromosomal Location82045712-82047525 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 82046625 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 62 (V62I)
Ref Sequence ENSEMBL: ENSMUSP00000021011 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021011]
Predicted Effect probably damaging
Transcript: ENSMUST00000021011
AA Change: V62I

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000021011
Gene: ENSMUSG00000035373
AA Change: V62I

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
SCY 30 88 3.33e-24 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit alterations in blood monocyte counts and in the monocytic response to thioglycollate-induced inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530077C05Rik T C 9: 22,444,130 V487A possibly damaging Het
Ankrd26 T G 6: 118,539,698 T502P probably damaging Het
Apoa4 C A 9: 46,242,985 Q295K probably benign Het
Asxl3 T G 18: 22,523,564 C1544G probably benign Het
Ceacam20 C A 7: 19,974,322 T284K possibly damaging Het
Ces4a A T 8: 105,145,227 probably benign Het
Col4a2 G T 8: 11,439,306 G1147V probably damaging Het
Gtf3c4 T C 2: 28,834,436 D428G possibly damaging Het
Itgb2 G A 10: 77,557,964 V413I possibly damaging Het
Itgb7 T G 15: 102,227,540 E20A possibly damaging Het
Kank2 C A 9: 21,794,604 G373W probably damaging Het
Kif1a T A 1: 93,082,340 I28F probably damaging Het
Klhdc7b T C 15: 89,387,369 V818A probably benign Het
Klhl20 T C 1: 161,093,726 Y53C probably damaging Het
Mroh1 A G 15: 76,432,288 N772S probably benign Het
Mtmr4 C T 11: 87,600,647 T146I probably benign Het
Nup210 C T 6: 91,040,564 V1152I probably benign Het
Pclo T A 5: 14,713,448 D3978E unknown Het
Pkd1l3 T C 8: 109,623,771 L416P probably benign Het
Pkn2 T C 3: 142,839,231 M161V possibly damaging Het
Plxnb2 T C 15: 89,162,683 probably null Het
Polr2e C A 10: 80,039,633 D3Y probably damaging Het
Prss27 A T 17: 24,038,371 probably benign Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Tmem30c T A 16: 57,276,742 I152F possibly damaging Het
Usp2 G A 9: 44,093,803 R378H probably damaging Het
Vmn2r106 A T 17: 20,268,310 I609N possibly damaging Het
Vmn2r51 T A 7: 10,102,454 E133D probably damaging Het
Zkscan3 A T 13: 21,394,091 probably benign Het
Other mutations in Ccl7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00540:Ccl7 APN 11 82047062 missense probably damaging 1.00
IGL00819:Ccl7 APN 11 82046575 missense probably benign 0.08
IGL03341:Ccl7 APN 11 82045835 missense probably benign 0.02
seoraksan UTSW 11 82046586 missense probably damaging 1.00
R0416:Ccl7 UTSW 11 82045866 splice site probably benign
R1864:Ccl7 UTSW 11 82046552 missense probably benign 0.00
R6161:Ccl7 UTSW 11 82046586 missense probably damaging 1.00
Posted On2013-12-09