Incidental Mutation 'IGL01574:Prss27'
ID 91200
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss27
Ensembl Gene ENSMUSG00000050762
Gene Name serine protease 27
Synonyms Pancreasin, Mpn, marapsin, CAPH2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01574
Quality Score
Status
Chromosome 17
Chromosomal Location 24257217-24264923 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 24257345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000056483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059482]
AlphaFold Q8BJR6
Predicted Effect probably benign
Transcript: ENSMUST00000059482
SMART Domains Protein: ENSMUSP00000056483
Gene: ENSMUSG00000050762

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Tryp_SPc 37 275 2.29e-92 SMART
low complexity region 283 301 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a gene trap allele develop normally and are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd26 T G 6: 118,516,659 (GRCm39) T502P probably damaging Het
Apoa4 C A 9: 46,154,283 (GRCm39) Q295K probably benign Het
Asxl3 T G 18: 22,656,621 (GRCm39) C1544G probably benign Het
Ccl7 G A 11: 81,937,451 (GRCm39) V62I probably damaging Het
Ceacam20 C A 7: 19,708,247 (GRCm39) T284K possibly damaging Het
Ces4a A T 8: 105,871,859 (GRCm39) probably benign Het
Col4a2 G T 8: 11,489,306 (GRCm39) G1147V probably damaging Het
Gtf3c4 T C 2: 28,724,448 (GRCm39) D428G possibly damaging Het
Itgb2 G A 10: 77,393,798 (GRCm39) V413I possibly damaging Het
Itgb7 T G 15: 102,135,975 (GRCm39) E20A possibly damaging Het
Kank2 C A 9: 21,705,900 (GRCm39) G373W probably damaging Het
Kif1a T A 1: 93,010,062 (GRCm39) I28F probably damaging Het
Klhdc7b T C 15: 89,271,572 (GRCm39) V818A probably benign Het
Klhl20 T C 1: 160,921,296 (GRCm39) Y53C probably damaging Het
Matcap2 T C 9: 22,355,426 (GRCm39) V487A possibly damaging Het
Mroh1 A G 15: 76,316,488 (GRCm39) N772S probably benign Het
Mtmr4 C T 11: 87,491,473 (GRCm39) T146I probably benign Het
Nup210 C T 6: 91,017,546 (GRCm39) V1152I probably benign Het
Pclo T A 5: 14,763,462 (GRCm39) D3978E unknown Het
Pkd1l3 T C 8: 110,350,403 (GRCm39) L416P probably benign Het
Pkn2 T C 3: 142,544,992 (GRCm39) M161V possibly damaging Het
Plxnb2 T C 15: 89,046,886 (GRCm39) probably null Het
Polr2e C A 10: 79,875,467 (GRCm39) D3Y probably damaging Het
Psmg2 G A 18: 67,786,293 (GRCm39) V218I probably benign Het
Tmem30c T A 16: 57,097,105 (GRCm39) I152F possibly damaging Het
Usp2 G A 9: 44,005,100 (GRCm39) R378H probably damaging Het
Vmn2r106 A T 17: 20,488,572 (GRCm39) I609N possibly damaging Het
Vmn2r51 T A 7: 9,836,381 (GRCm39) E133D probably damaging Het
Zkscan3 A T 13: 21,578,261 (GRCm39) probably benign Het
Other mutations in Prss27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01633:Prss27 APN 17 24,264,650 (GRCm39) missense probably damaging 1.00
IGL02096:Prss27 APN 17 24,263,951 (GRCm39) missense possibly damaging 0.94
IGL02318:Prss27 APN 17 24,264,571 (GRCm39) missense probably benign 0.01
IGL02491:Prss27 APN 17 24,263,229 (GRCm39) splice site probably benign
IGL02715:Prss27 APN 17 24,263,953 (GRCm39) missense possibly damaging 0.94
R1582:Prss27 UTSW 17 24,263,877 (GRCm39) missense probably benign 0.11
R5078:Prss27 UTSW 17 24,263,414 (GRCm39) nonsense probably null
R5468:Prss27 UTSW 17 24,257,287 (GRCm39) missense possibly damaging 0.53
R6415:Prss27 UTSW 17 24,261,882 (GRCm39) nonsense probably null
R6450:Prss27 UTSW 17 24,263,988 (GRCm39) nonsense probably null
R6477:Prss27 UTSW 17 24,263,235 (GRCm39) missense probably damaging 1.00
R7143:Prss27 UTSW 17 24,264,632 (GRCm39) missense probably damaging 1.00
R7285:Prss27 UTSW 17 24,264,665 (GRCm39) missense probably benign 0.01
R7447:Prss27 UTSW 17 24,264,683 (GRCm39) missense probably damaging 1.00
R7825:Prss27 UTSW 17 24,261,932 (GRCm39) missense probably damaging 1.00
R8240:Prss27 UTSW 17 24,263,919 (GRCm39) missense probably benign 0.04
R9371:Prss27 UTSW 17 24,257,141 (GRCm39) start gained probably benign
R9767:Prss27 UTSW 17 24,257,283 (GRCm39) start codon destroyed probably null 0.33
Posted On 2013-12-09