Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01575:Ifna15'

91203

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna15

Ensembl Gene

ENSMUSG00000096011

Gene Name

interferon alpha 15

Synonyms

Gm12597, Ifnaa

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL01575

Quality Score

Status

Chromosome

Chromosomal Location

88475910-88476482 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88476044 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 147 (F147L)

Ref Sequence

ENSEMBL: ENSMUSP00000099873 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102809]

AlphaFold

Q61718

Predicted Effect

probably damaging
Transcript: ENSMUST00000102809
AA Change: F147L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000099873
Gene: ENSMUSG00000096011
AA Change: F147L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.97e-68	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Anapc2	C	T	2: 25,175,188 (GRCm39)		probably benign	Het
Atp10b	G	A	11: 43,063,548 (GRCm39)	R161H	probably benign	Het
Boll	A	G	1: 55,362,807 (GRCm39)		probably null	Het
Cngb1	G	A	8: 95,991,148 (GRCm39)	P226S	possibly damaging	Het
Commd3	G	A	2: 18,679,528 (GRCm39)		probably null	Het
Ddx46	C	T	13: 55,801,996 (GRCm39)		probably benign	Het
Dmrtb1	A	G	4: 107,541,265 (GRCm39)	I32T	probably benign	Het
Dnah7a	T	C	1: 53,466,979 (GRCm39)		probably benign	Het
Dppa5a	A	G	9: 78,275,062 (GRCm39)	I80T	possibly damaging	Het
Galntl6	T	C	8: 58,880,710 (GRCm39)		probably benign	Het
Hmgcr	A	G	13: 96,793,103 (GRCm39)	Y510H	possibly damaging	Het
Idua	G	T	5: 108,829,973 (GRCm39)	R505L	possibly damaging	Het
Itga4	T	C	2: 79,118,599 (GRCm39)	S433P	probably damaging	Het
Kcnc1	T	C	7: 46,077,523 (GRCm39)	Y442H	possibly damaging	Het
Kmt2d	A	G	15: 98,744,736 (GRCm39)		probably benign	Het
Mpp7	A	G	18: 7,403,365 (GRCm39)		probably benign	Het
Or14c39	T	C	7: 86,344,501 (GRCm39)	V279A	probably benign	Het
Or5p64	A	C	7: 107,854,742 (GRCm39)	V201G	possibly damaging	Het
Or6c75	A	G	10: 129,337,436 (GRCm39)	I228V	probably benign	Het
Pam16l	T	C	10: 43,400,411 (GRCm39)	V55A	probably benign	Het
Phf14	T	C	6: 11,990,050 (GRCm39)	L693S	probably damaging	Het
Pkd1	A	G	17: 24,792,102 (GRCm39)	N1263S	probably damaging	Het
Rhbdl1	G	T	17: 26,055,112 (GRCm39)	A32E	possibly damaging	Het
Samd9l	A	G	6: 3,376,734 (GRCm39)	S176P	possibly damaging	Het
Scn1a	G	T	2: 66,103,580 (GRCm39)	F1893L	probably damaging	Het
Serpina3f	C	A	12: 104,184,699 (GRCm39)	P281Q	probably damaging	Het
Slc35a1	G	T	4: 34,668,932 (GRCm39)	Q294K	probably benign	Het
Sspo	G	A	6: 48,435,976 (GRCm39)	S1154N	probably benign	Het
Tdrd6	A	G	17: 43,938,871 (GRCm39)	S726P	probably benign	Het
Tiam2	A	T	17: 3,504,591 (GRCm39)	E24V	probably damaging	Het
Tmf1	T	C	6: 97,152,897 (GRCm39)	E392G	probably damaging	Het
Tns2	T	C	15: 102,021,626 (GRCm39)	V1089A	probably damaging	Het
Tspyl1	C	A	10: 34,159,086 (GRCm39)	N270K	probably damaging	Het
Usp32	A	T	11: 84,913,628 (GRCm39)	V901D	probably damaging	Het
Vldlr	A	G	19: 27,224,031 (GRCm39)	I764V	probably benign	Het
Wnk2	A	G	13: 49,300,152 (GRCm39)	V186A	probably damaging	Het
Zdhhc18	A	G	4: 133,341,210 (GRCm39)	V221A	probably damaging	Het

Other mutations in Ifna15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01757:Ifna15	APN	4	88,476,322 (GRCm39)	missense	possibly damaging	0.79
IGL01824:Ifna15	APN	4	88,476,020 (GRCm39)	missense	probably benign	0.00
R3853:Ifna15	UTSW	4	88,476,046 (GRCm39)	missense	probably damaging	1.00
R4356:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R4357:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R4358:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R4359:Ifna15	UTSW	4	88,476,079 (GRCm39)	missense	probably benign	0.09
R5038:Ifna15	UTSW	4	88,476,266 (GRCm39)	missense	probably benign	0.03
R5372:Ifna15	UTSW	4	88,476,338 (GRCm39)	missense	probably damaging	0.97
R6036:Ifna15	UTSW	4	88,476,310 (GRCm39)	missense	possibly damaging	0.65
R6036:Ifna15	UTSW	4	88,476,310 (GRCm39)	missense	possibly damaging	0.65
R7347:Ifna15	UTSW	4	88,476,220 (GRCm39)	missense	probably damaging	1.00
R8097:Ifna15	UTSW	4	88,475,938 (GRCm39)	missense	probably benign	0.01
R8132:Ifna15	UTSW	4	88,475,920 (GRCm39)	missense	possibly damaging	0.60
R8824:Ifna15	UTSW	4	88,475,998 (GRCm39)	missense	probably damaging	1.00
R9349:Ifna15	UTSW	4	88,476,283 (GRCm39)	missense	probably benign	0.10

Posted On

2013-12-09