Incidental Mutation 'IGL01575:Olfr292'
ID91211
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr292
Ensembl Gene ENSMUSG00000060688
Gene Nameolfactory receptor 292
SynonymsGA_x6K02T2NHDJ-9425121-9424195, MOR220-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL01575
Quality Score
Status
Chromosome7
Chromosomal Location86688330-86697507 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 86695293 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 279 (V279A)
Ref Sequence ENSEMBL: ENSMUSP00000079060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080165]
Predicted Effect probably benign
Transcript: ENSMUST00000080165
AA Change: V279A

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000079060
Gene: ENSMUSG00000060688
AA Change: V279A

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 2.6e-48 PFAM
Pfam:7tm_1 39 288 2.7e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc2 C T 2: 25,285,176 probably benign Het
Atp10b G A 11: 43,172,721 R161H probably benign Het
Boll A G 1: 55,323,648 probably null Het
Cngb1 G A 8: 95,264,520 P226S possibly damaging Het
Commd3 G A 2: 18,674,717 probably null Het
Ddx46 C T 13: 55,654,183 probably benign Het
Dmrtb1 A G 4: 107,684,068 I32T probably benign Het
Dnah7a T C 1: 53,427,820 probably benign Het
Dppa5a A G 9: 78,367,780 I80T possibly damaging Het
Galntl6 T C 8: 58,427,676 probably benign Het
Gm9803 T C 10: 43,524,415 V55A probably benign Het
Hmgcr A G 13: 96,656,595 Y510H possibly damaging Het
Idua G T 5: 108,682,107 R505L possibly damaging Het
Ifna15 A G 4: 88,557,807 F147L probably damaging Het
Itga4 T C 2: 79,288,255 S433P probably damaging Het
Kcnc1 T C 7: 46,428,099 Y442H possibly damaging Het
Kmt2d A G 15: 98,846,855 probably benign Het
Mpp7 A G 18: 7,403,365 probably benign Het
Olfr488 A C 7: 108,255,535 V201G possibly damaging Het
Olfr790 A G 10: 129,501,567 I228V probably benign Het
Phf14 T C 6: 11,990,051 L693S probably damaging Het
Pkd1 A G 17: 24,573,128 N1263S probably damaging Het
Rhbdl1 G T 17: 25,836,138 A32E possibly damaging Het
Samd9l A G 6: 3,376,734 S176P possibly damaging Het
Scn1a G T 2: 66,273,236 F1893L probably damaging Het
Serpina3f C A 12: 104,218,440 P281Q probably damaging Het
Slc35a1 G T 4: 34,668,932 Q294K probably benign Het
Sspo G A 6: 48,459,042 S1154N probably benign Het
Tdrd6 A G 17: 43,627,980 S726P probably benign Het
Tiam2 A T 17: 3,454,316 E24V probably damaging Het
Tmf1 T C 6: 97,175,936 E392G probably damaging Het
Tns2 T C 15: 102,113,191 V1089A probably damaging Het
Tspyl1 C A 10: 34,283,090 N270K probably damaging Het
Usp32 A T 11: 85,022,802 V901D probably damaging Het
Vldlr A G 19: 27,246,631 I764V probably benign Het
Wnk2 A G 13: 49,146,676 V186A probably damaging Het
Zdhhc18 A G 4: 133,613,899 V221A probably damaging Het
Other mutations in Olfr292
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01751:Olfr292 APN 7 86694789 missense probably benign
IGL02417:Olfr292 APN 7 86694819 missense probably damaging 1.00
IGL02534:Olfr292 APN 7 86694731 missense probably benign 0.17
IGL02830:Olfr292 APN 7 86695174 missense probably damaging 1.00
R0281:Olfr292 UTSW 7 86694860 missense probably benign 0.00
R0423:Olfr292 UTSW 7 86695226 missense possibly damaging 0.95
R0555:Olfr292 UTSW 7 86695308 missense probably damaging 1.00
R0609:Olfr292 UTSW 7 86694876 missense possibly damaging 0.85
R0662:Olfr292 UTSW 7 86694630 missense possibly damaging 0.88
R1710:Olfr292 UTSW 7 86695110 missense probably benign 0.00
R2144:Olfr292 UTSW 7 86695280 missense probably damaging 0.98
R4400:Olfr292 UTSW 7 86694590 missense probably benign 0.10
R4615:Olfr292 UTSW 7 86694728 missense probably damaging 1.00
R4762:Olfr292 UTSW 7 86695121 missense probably benign 0.01
R4785:Olfr292 UTSW 7 86694528 missense probably damaging 1.00
R4823:Olfr292 UTSW 7 86694588 missense probably damaging 0.99
R4908:Olfr292 UTSW 7 86695187 missense probably benign 0.00
R4983:Olfr292 UTSW 7 86694479 missense probably benign 0.01
R5010:Olfr292 UTSW 7 86694585 missense possibly damaging 0.95
R5024:Olfr292 UTSW 7 86694881 missense probably benign 0.05
R5157:Olfr292 UTSW 7 86695232 missense probably benign 0.19
R5627:Olfr292 UTSW 7 86695139 missense possibly damaging 0.93
R6327:Olfr292 UTSW 7 86694552 missense probably benign 0.09
R6375:Olfr292 UTSW 7 86695059 missense probably benign 0.01
R6775:Olfr292 UTSW 7 86695149 missense probably benign 0.02
R7257:Olfr292 UTSW 7 86694804 missense probably damaging 0.99
R7383:Olfr292 UTSW 7 86694752 missense probably damaging 0.97
Posted On2013-12-09