Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01576:Fndc10'

91271

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fndc10

Ensembl Gene

ENSMUSG00000074738

Gene Name

fibronectin type III domain containing 10

Synonyms

B930041F14Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.161) question?

Stock #

IGL01576

Quality Score

Status

Chromosome

Chromosomal Location

155778799-155780938 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 155779433 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 159 (V159D)

Ref Sequence

ENSEMBL: ENSMUSP00000096871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099265]

AlphaFold

A2A9Q0

Predicted Effect

probably benign
Transcript: ENSMUST00000099265
AA Change: V159D

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000096871
Gene: ENSMUSG00000074738
AA Change: V159D

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Blast:FN3	75	151	2e-24	BLAST
transmembrane domain	183	205	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	A	G	6: 128,531,293 (GRCm39)		probably benign	Het
Ank3	A	G	10: 69,816,121 (GRCm39)	E541G	probably damaging	Het
Arhgef5	A	T	6: 43,250,962 (GRCm39)	D571V	probably benign	Het
Birc6	A	G	17: 74,984,365 (GRCm39)	N4459S	possibly damaging	Het
Brsk2	T	C	7: 141,535,292 (GRCm39)	I38T	possibly damaging	Het
Cacna2d4	A	T	6: 119,258,602 (GRCm39)	R563*	probably null	Het
Car7	T	A	8: 105,276,180 (GRCm39)		probably null	Het
Chml	T	C	1: 175,515,271 (GRCm39)	T217A	probably benign	Het
Dnah7b	T	G	1: 46,307,813 (GRCm39)	N3042K	probably damaging	Het
Efcab2	T	G	1: 178,264,957 (GRCm39)		probably benign	Het
Espn	T	C	4: 152,208,174 (GRCm39)	E397G	probably damaging	Het
Fam20c	A	G	5: 138,793,094 (GRCm39)	T443A	probably damaging	Het
Fam221b	T	C	4: 43,666,227 (GRCm39)	E128G	probably benign	Het
Fat4	A	G	3: 38,943,096 (GRCm39)	D663G	probably damaging	Het
Gm14496	A	G	2: 181,633,164 (GRCm39)	Y49C	possibly damaging	Het
Gpr63	G	T	4: 25,008,445 (GRCm39)	D390Y	possibly damaging	Het
Herc2	G	A	7: 55,876,409 (GRCm39)		probably null	Het
Igdcc3	A	G	9: 65,085,152 (GRCm39)	T199A	probably damaging	Het
Ireb2	T	C	9: 54,799,794 (GRCm39)	Y412H	probably damaging	Het
Lpin3	T	C	2: 160,739,047 (GRCm39)	V285A	probably benign	Het
Mdga1	T	C	17: 30,062,101 (GRCm39)	S443G	possibly damaging	Het
Med22	C	T	2: 26,799,004 (GRCm39)		probably null	Het
Or7c70	G	T	10: 78,683,207 (GRCm39)	L181I	possibly damaging	Het
Pals2	G	A	6: 50,140,472 (GRCm39)	R164Q	probably benign	Het
Pcnt	T	G	10: 76,204,656 (GRCm39)	D2583A	probably damaging	Het
Pkn3	G	A	2: 29,977,054 (GRCm39)	R598Q	probably damaging	Het
Pnpla7	T	C	2: 24,906,575 (GRCm39)	V646A	probably damaging	Het
Podxl	A	T	6: 31,501,319 (GRCm39)	V412D	probably damaging	Het
Rad51ap1	A	T	6: 126,905,123 (GRCm39)	S129R	probably damaging	Het
Relb	T	C	7: 19,346,526 (GRCm39)	I349V	probably benign	Het
Rorb	C	T	19: 18,934,698 (GRCm39)	G224D	probably damaging	Het
Slc40a1	T	A	1: 45,948,757 (GRCm39)	I508F	probably damaging	Het
Tanc1	G	A	2: 59,628,079 (GRCm39)	V619M	probably damaging	Het
Tgm7	A	T	2: 120,931,514 (GRCm39)	D216E	probably damaging	Het
Tmem132e	A	G	11: 82,329,200 (GRCm39)	D493G	probably damaging	Het
Zfp110	T	A	7: 12,583,598 (GRCm39)	C749S	probably damaging	Het
Zscan4d	T	C	7: 10,896,519 (GRCm39)	N284D	possibly damaging	Het

Other mutations in Fndc10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1721:Fndc10	UTSW	4	155,779,355 (GRCm39)	missense	probably damaging	1.00
R4621:Fndc10	UTSW	4	155,779,264 (GRCm39)	missense	probably damaging	0.99
R7095:Fndc10	UTSW	4	155,779,574 (GRCm39)	missense	probably damaging	0.99
R7498:Fndc10	UTSW	4	155,779,195 (GRCm39)	missense	probably damaging	1.00
R7561:Fndc10	UTSW	4	155,779,328 (GRCm39)	missense	probably damaging	0.99
R9269:Fndc10	UTSW	4	155,779,205 (GRCm39)	missense	possibly damaging	0.90
R9484:Fndc10	UTSW	4	155,779,496 (GRCm39)	missense	possibly damaging	0.92

Posted On

2013-12-09