Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01583:Lrrc28'

91454

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc28

Ensembl Gene

ENSMUSG00000030556

Gene Name

leucine rich repeat containing 28

Synonyms

2310058O11Rik, 2210012C09Rik, 1300004K21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL01583

Quality Score

Status

Chromosome

Chromosomal Location

67163158-67295016 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 67195223 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000140972 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053950] [ENSMUST00000187953] [ENSMUST00000190276] [ENSMUST00000191035]

AlphaFold

Q3TX51

Predicted Effect

probably null
Transcript: ENSMUST00000053950

SMART Domains

Protein: ENSMUSP00000052177
Gene: ENSMUSG00000030556

Domain	Start	End	E-Value	Type
LRR	40	63	1.33e-1	SMART
LRR	64	86	3.24e0	SMART
LRR	87	109	1.06e1	SMART
LRR_TYP	110	132	6.67e-2	SMART
LRR	133	156	6.4e0	SMART
LRR	179	202	1.64e-1	SMART
low complexity region	304	318	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000187953

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188971

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190115

Predicted Effect

probably null
Transcript: ENSMUST00000190276

SMART Domains

Protein: ENSMUSP00000140972
Gene: ENSMUSG00000030556

Domain	Start	End	E-Value	Type
LRR	40	59	3.7e-3	SMART
LRR	64	83	1.2e0	SMART
LRR	87	109	4.4e-2	SMART
LRR_TYP	110	133	2.3e-6	SMART
LRR	133	153	1.1e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190770

Predicted Effect

probably benign
Transcript: ENSMUST00000191035

SMART Domains

Protein: ENSMUSP00000140382
Gene: ENSMUSG00000030556

Domain	Start	End	E-Value	Type
LRR	40	63	1.33e-1	SMART
LRR	64	86	3.24e0	SMART
LRR	87	109	1.06e1	SMART
LRR	110	132	8.09e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191062

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	A	T	2: 69,126,753 (GRCm39)	M329K	possibly damaging	Het
Abce1	G	A	8: 80,420,076 (GRCm39)	T300M	probably damaging	Het
Acap1	G	A	11: 69,772,503 (GRCm39)	S536L	probably damaging	Het
Adcy5	C	A	16: 35,103,883 (GRCm39)		probably benign	Het
Ap2b1	G	T	11: 83,215,437 (GRCm39)	R127L	possibly damaging	Het
Asxl3	T	G	18: 22,649,654 (GRCm39)	S548A	probably benign	Het
Atm	G	A	9: 53,395,547 (GRCm39)		probably benign	Het
Cep250	T	C	2: 155,818,069 (GRCm39)	V807A	probably damaging	Het
Ces1g	T	A	8: 94,033,587 (GRCm39)	Y445F	probably damaging	Het
Cnksr3	A	G	10: 7,070,512 (GRCm39)	Y241H	probably benign	Het
Col9a1	T	C	1: 24,224,225 (GRCm39)	S136P	unknown	Het
Cux2	C	A	5: 122,012,170 (GRCm39)	G422W	probably damaging	Het
Cyp1a2	A	T	9: 57,589,655 (GRCm39)	M53K	probably benign	Het
Ddx20	T	C	3: 105,593,986 (GRCm39)	D123G	probably damaging	Het
Dock4	T	A	12: 40,860,466 (GRCm39)	L1284*	probably null	Het
Dpp9	A	C	17: 56,518,666 (GRCm39)	L46R	probably benign	Het
Elavl1	A	T	8: 4,351,699 (GRCm39)	V139E	probably damaging	Het
Fndc3b	T	C	3: 27,483,144 (GRCm39)	Y1018C	probably damaging	Het
Fubp1	A	G	3: 151,921,261 (GRCm39)	N78D	possibly damaging	Het
Fubp3	C	T	2: 31,501,755 (GRCm39)		probably benign	Het
Gbx2	C	A	1: 89,856,559 (GRCm39)	R277L	probably damaging	Het
Gm128	T	C	3: 95,148,094 (GRCm39)	R67G	possibly damaging	Het
Gpc2	T	A	5: 138,273,792 (GRCm39)	R469W	probably damaging	Het
Ifi30	G	A	8: 71,217,407 (GRCm39)		probably benign	Het
Kbtbd4	T	C	2: 90,736,252 (GRCm39)	S88P	probably damaging	Het
Kif23	A	T	9: 61,842,750 (GRCm39)	Y216N	probably damaging	Het
Lgals4	A	G	7: 28,540,973 (GRCm39)	D299G	probably damaging	Het
Lmx1b	A	G	2: 33,459,071 (GRCm39)	S161P	probably benign	Het
Lrcol1	T	A	5: 110,502,444 (GRCm39)	S107T	probably benign	Het
Ncoa4	T	C	14: 31,894,884 (GRCm39)	V42A	probably benign	Het
Nkd2	C	T	13: 73,969,599 (GRCm39)	S277N	probably benign	Het
Nlrp2	A	T	7: 5,340,769 (GRCm39)	L15Q	probably damaging	Het
Nynrin	T	G	14: 56,107,968 (GRCm39)	L1025R	probably damaging	Het
Or12d12	C	T	17: 37,610,629 (GRCm39)	R228H	probably benign	Het
Or5w1	G	T	2: 87,486,757 (GRCm39)	C169*	probably null	Het
Piwil4	A	T	9: 14,645,783 (GRCm39)	F152I	probably damaging	Het
Plod3	T	C	5: 137,025,002 (GRCm39)	S705P	probably benign	Het
Ppp2r2c	T	A	5: 37,026,166 (GRCm39)	M1K	probably null	Het
Rgs19	T	C	2: 181,331,246 (GRCm39)	E129G	probably damaging	Het
Rpap2	T	A	5: 107,768,061 (GRCm39)	S223T	probably damaging	Het
Shox2	T	C	3: 66,881,104 (GRCm39)		probably benign	Het
Slc30a4	T	C	2: 122,527,137 (GRCm39)	I370V	probably benign	Het
Slco1b2	A	G	6: 141,609,398 (GRCm39)	I269M	possibly damaging	Het
Slco1c1	A	G	6: 141,485,793 (GRCm39)	Y142C	probably damaging	Het
Slco3a1	T	C	7: 73,934,198 (GRCm39)	N658S	probably benign	Het
Sos1	A	T	17: 80,741,329 (GRCm39)	S485R	probably benign	Het
Srpk1	A	G	17: 28,825,291 (GRCm39)	L127P	probably damaging	Het
St3gal6	T	A	16: 58,314,033 (GRCm39)		probably benign	Het
Stk4	T	A	2: 163,916,134 (GRCm39)	M1K	probably null	Het
Tbc1d12	A	G	19: 38,871,176 (GRCm39)	E313G	probably benign	Het
Tbk1	A	G	10: 121,393,134 (GRCm39)	I472T	probably benign	Het
Tiam1	G	A	16: 89,586,168 (GRCm39)	R849W	probably damaging	Het
Tle3	A	G	9: 61,317,307 (GRCm39)	T381A	probably benign	Het
Tmem82	T	G	4: 141,341,954 (GRCm39)	T337P	probably benign	Het
Tmprss15	T	C	16: 78,868,149 (GRCm39)	T220A	probably benign	Het
Ung	A	G	5: 114,275,369 (GRCm39)	K242E	possibly damaging	Het
Vmn1r211	A	T	13: 23,036,571 (GRCm39)	M32K	probably benign	Het
Vps13d	T	G	4: 144,771,658 (GRCm39)	D956A	probably damaging	Het
Wdr64	T	A	1: 175,594,722 (GRCm39)		probably null	Het

Other mutations in Lrrc28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01548:Lrrc28	APN	7	67,278,042 (GRCm39)	critical splice donor site	probably null
IGL02033:Lrrc28	APN	7	67,209,605 (GRCm39)	critical splice donor site	probably null
IGL02483:Lrrc28	APN	7	67,267,731 (GRCm39)	splice site	probably benign
IGL02750:Lrrc28	APN	7	67,181,431 (GRCm39)	missense	probably damaging	0.96
BB002:Lrrc28	UTSW	7	67,268,857 (GRCm39)	missense	probably damaging	1.00
BB012:Lrrc28	UTSW	7	67,268,857 (GRCm39)	missense	probably damaging	1.00
R0549:Lrrc28	UTSW	7	67,278,090 (GRCm39)	splice site	probably benign
R0563:Lrrc28	UTSW	7	67,195,135 (GRCm39)	missense	probably damaging	1.00
R0650:Lrrc28	UTSW	7	67,267,833 (GRCm39)	missense	probably damaging	1.00
R0652:Lrrc28	UTSW	7	67,267,833 (GRCm39)	missense	probably damaging	1.00
R1557:Lrrc28	UTSW	7	67,209,677 (GRCm39)	missense	probably damaging	1.00
R1820:Lrrc28	UTSW	7	67,290,859 (GRCm39)	missense	probably damaging	0.98
R2149:Lrrc28	UTSW	7	67,181,430 (GRCm39)	missense	probably damaging	0.96
R2185:Lrrc28	UTSW	7	67,195,201 (GRCm39)	missense	possibly damaging	0.70
R4479:Lrrc28	UTSW	7	67,181,362 (GRCm39)	critical splice donor site	probably null
R5205:Lrrc28	UTSW	7	67,181,516 (GRCm39)	missense	probably benign	0.00
R7008:Lrrc28	UTSW	7	67,245,459 (GRCm39)	intron	probably benign
R7925:Lrrc28	UTSW	7	67,268,857 (GRCm39)	missense	probably damaging	1.00
R8323:Lrrc28	UTSW	7	67,245,455 (GRCm39)	missense	unknown
R8360:Lrrc28	UTSW	7	67,290,909 (GRCm39)	missense	probably benign	0.01
R8898:Lrrc28	UTSW	7	67,278,042 (GRCm39)	critical splice donor site	probably null
R8919:Lrrc28	UTSW	7	67,268,833 (GRCm39)	missense	possibly damaging	0.88
R9412:Lrrc28	UTSW	7	67,181,512 (GRCm39)	missense	probably damaging	1.00
Z1088:Lrrc28	UTSW	7	67,179,379 (GRCm39)	missense	possibly damaging	0.89

Posted On

2013-12-09