Incidental Mutation 'IGL01584:Lrrn4'
ID 91491
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrn4
Ensembl Gene ENSMUSG00000043110
Gene Name leucine rich repeat neuronal 4
Synonyms B430119L13Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL01584
Quality Score
Status
Chromosome 2
Chromosomal Location 132710225-132722811 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 132719996 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 268 (L268P)
Ref Sequence ENSEMBL: ENSMUSP00000057005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049787]
AlphaFold P59383
Predicted Effect probably damaging
Transcript: ENSMUST00000049787
AA Change: L268P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057005
Gene: ENSMUSG00000043110
AA Change: L268P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
LRR 105 126 7.36e0 SMART
LRR_TYP 128 151 3.44e-4 SMART
LRR 153 175 1.19e1 SMART
LRR 176 199 1.53e1 SMART
LRR 205 228 2.03e1 SMART
LRR 229 253 3.36e2 SMART
LRRCT 311 363 6.92e-2 SMART
low complexity region 520 530 N/A INTRINSIC
FN3 577 656 3.73e-10 SMART
transmembrane domain 679 701 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibit impaired memory retention in hippocampus- dependent learning tasks such as contextual conditioning and spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 A G 11: 110,195,749 (GRCm39) V570A probably damaging Het
Abcb1a T C 5: 8,748,637 (GRCm39) S323P possibly damaging Het
Adcy8 C T 15: 64,687,170 (GRCm39) D445N probably damaging Het
Cdc14a A T 3: 116,186,474 (GRCm39) Y102* probably null Het
Cubn A G 2: 13,313,472 (GRCm39) probably benign Het
Dcaf7 T C 11: 105,944,653 (GRCm39) S279P probably benign Het
Dock10 T C 1: 80,511,567 (GRCm39) Q1514R probably damaging Het
Dtx2 G A 5: 136,055,420 (GRCm39) S369N possibly damaging Het
Dusp11 A G 6: 85,930,376 (GRCm39) F136S probably damaging Het
Fbxo32 T C 15: 58,047,632 (GRCm39) D227G probably damaging Het
Flg2 T A 3: 93,120,773 (GRCm39) V1215E unknown Het
Flg2 A T 3: 93,122,777 (GRCm39) D1649V unknown Het
Gabbr2 T C 4: 46,674,524 (GRCm39) K821R probably damaging Het
Gga2 T C 7: 121,590,761 (GRCm39) T516A probably benign Het
Gm15446 T A 5: 110,088,668 (GRCm39) *64K probably null Het
Gm5900 T C 7: 104,599,361 (GRCm39) noncoding transcript Het
Il17rb A G 14: 29,725,637 (GRCm39) F121S probably damaging Het
Ip6k3 C A 17: 27,370,034 (GRCm39) R128L probably benign Het
Kmt2d A T 15: 98,754,250 (GRCm39) probably benign Het
Mthfd1l C A 10: 3,966,738 (GRCm39) S332R probably damaging Het
Or12d12 C T 17: 37,610,629 (GRCm39) R228H probably benign Het
Or5t17 G A 2: 86,832,495 (GRCm39) V61I probably benign Het
Pdzd2 T C 15: 12,592,569 (GRCm39) E25G probably damaging Het
Prima1 A T 12: 103,169,047 (GRCm39) probably null Het
Rbm26 A G 14: 105,368,968 (GRCm39) V737A probably damaging Het
Ryr2 C T 13: 11,616,644 (GRCm39) probably null Het
Sema5b G T 16: 35,465,793 (GRCm39) C114F probably damaging Het
Spata31f1e A C 4: 42,794,014 (GRCm39) S39R probably damaging Het
Speg T C 1: 75,407,581 (GRCm39) V3196A probably damaging Het
Svs3b T C 2: 164,097,943 (GRCm39) Y126C probably benign Het
Tmem171 T C 13: 98,828,683 (GRCm39) probably null Het
Tnrc6b T A 15: 80,763,883 (GRCm39) W462R probably benign Het
Trdmt1 T C 2: 13,524,739 (GRCm39) R239G probably benign Het
Usp5 A T 6: 124,796,350 (GRCm39) V583E probably damaging Het
Utrn A G 10: 12,602,111 (GRCm39) V639A probably benign Het
Vmn1r206 T C 13: 22,804,964 (GRCm39) K81R probably damaging Het
Vwa3a A G 7: 120,383,197 (GRCm39) I599M probably benign Het
Other mutations in Lrrn4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Lrrn4 APN 2 132,712,737 (GRCm39) missense probably damaging 1.00
IGL00661:Lrrn4 APN 2 132,712,588 (GRCm39) missense probably benign 0.08
IGL01542:Lrrn4 APN 2 132,721,392 (GRCm39) missense probably benign
IGL01723:Lrrn4 APN 2 132,711,981 (GRCm39) missense possibly damaging 0.79
R0270:Lrrn4 UTSW 2 132,712,639 (GRCm39) missense probably benign 0.01
R0348:Lrrn4 UTSW 2 132,712,363 (GRCm39) missense probably benign 0.02
R0400:Lrrn4 UTSW 2 132,719,940 (GRCm39) missense probably benign 0.12
R0701:Lrrn4 UTSW 2 132,712,080 (GRCm39) missense probably benign 0.02
R1465:Lrrn4 UTSW 2 132,713,995 (GRCm39) missense probably damaging 1.00
R1465:Lrrn4 UTSW 2 132,713,995 (GRCm39) missense probably damaging 1.00
R1664:Lrrn4 UTSW 2 132,711,886 (GRCm39) missense probably damaging 1.00
R1987:Lrrn4 UTSW 2 132,712,363 (GRCm39) missense probably benign 0.02
R3409:Lrrn4 UTSW 2 132,721,781 (GRCm39) missense unknown
R3743:Lrrn4 UTSW 2 132,711,786 (GRCm39) splice site probably null
R4678:Lrrn4 UTSW 2 132,721,488 (GRCm39) missense probably benign 0.16
R5770:Lrrn4 UTSW 2 132,714,076 (GRCm39) missense probably damaging 1.00
R6438:Lrrn4 UTSW 2 132,712,062 (GRCm39) missense probably damaging 1.00
R6511:Lrrn4 UTSW 2 132,712,246 (GRCm39) missense probably benign 0.06
R6880:Lrrn4 UTSW 2 132,714,032 (GRCm39) missense probably damaging 0.96
R7132:Lrrn4 UTSW 2 132,721,613 (GRCm39) nonsense probably null
R7273:Lrrn4 UTSW 2 132,721,749 (GRCm39) missense unknown
R7424:Lrrn4 UTSW 2 132,711,663 (GRCm39) missense possibly damaging 0.90
R7710:Lrrn4 UTSW 2 132,721,451 (GRCm39) missense probably benign 0.00
R7980:Lrrn4 UTSW 2 132,720,096 (GRCm39) missense probably damaging 1.00
R8133:Lrrn4 UTSW 2 132,719,934 (GRCm39) missense probably damaging 1.00
R8229:Lrrn4 UTSW 2 132,711,807 (GRCm39) missense probably damaging 1.00
R8489:Lrrn4 UTSW 2 132,721,364 (GRCm39) missense probably benign 0.20
R8956:Lrrn4 UTSW 2 132,714,011 (GRCm39) missense probably damaging 1.00
R9337:Lrrn4 UTSW 2 132,712,552 (GRCm39) missense probably benign 0.11
R9342:Lrrn4 UTSW 2 132,712,290 (GRCm39) missense probably benign
Posted On 2013-12-09