Incidental Mutation 'IGL01588:Olfr653'
ID91498
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr653
Ensembl Gene ENSMUSG00000073926
Gene Nameolfactory receptor 653
SynonymsMOR33-1, GA_x6K02T2PBJ9-7206970-7207923
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL01588
Quality Score
Status
Chromosome7
Chromosomal Location104577314-104584117 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 104579943 bp
ZygosityHeterozygous
Amino Acid Change Serine to Phenylalanine at position 99 (S99F)
Ref Sequence ENSEMBL: ENSMUSP00000149192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098174] [ENSMUST00000215585] [ENSMUST00000217466]
Predicted Effect probably damaging
Transcript: ENSMUST00000098174
AA Change: S99F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000095776
Gene: ENSMUSG00000073926
AA Change: S99F

DomainStartEndE-ValueType
Pfam:7tm_4 37 316 2.2e-111 PFAM
Pfam:7TM_GPCR_Srsx 41 179 4.6e-10 PFAM
Pfam:7tm_1 47 298 5.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215585
AA Change: S99F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000217466
AA Change: S99F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aspm T A 1: 139,478,162 S1596T probably benign Het
Atp10b G A 11: 43,172,721 R161H probably benign Het
Csn2 T C 5: 87,694,649 H165R probably benign Het
Dido1 A G 2: 180,688,875 V260A probably benign Het
Ece1 C T 4: 137,957,206 probably benign Het
Garem1 T G 18: 21,129,797 R653S probably damaging Het
Gpatch2 A T 1: 187,230,794 S261C probably damaging Het
Ing4 A G 6: 125,043,986 N24D possibly damaging Het
Klhdc7a A T 4: 139,966,946 V230D probably damaging Het
Ly96 G A 1: 16,709,454 V116I probably benign Het
Myom1 C T 17: 71,117,437 T1427M possibly damaging Het
Nedd1 C A 10: 92,686,262 V638L probably benign Het
Olfr1161 T C 2: 88,025,073 V117A probably benign Het
Olfr948 G A 9: 39,318,832 Q261* probably null Het
Pbx2 T C 17: 34,595,618 probably benign Het
Phlpp1 A T 1: 106,380,389 H1132L probably damaging Het
Plpp5 T A 8: 25,724,168 H237Q probably damaging Het
Stard13 C T 5: 151,045,237 R856H probably damaging Het
Sult1e1 T C 5: 87,576,243 K285R probably benign Het
Ubxn8 C T 8: 33,621,559 V269M probably damaging Het
Usp29 A T 7: 6,962,611 K484N probably benign Het
Whrn C T 4: 63,472,778 V80M probably damaging Het
Znhit6 A G 3: 145,596,207 probably benign Het
Other mutations in Olfr653
AlleleSourceChrCoordTypePredicted EffectPPH Score
I2288:Olfr653 UTSW 7 104580386 missense probably damaging 1.00
PIT4131001:Olfr653 UTSW 7 104580030 missense probably damaging 0.99
R0325:Olfr653 UTSW 7 104580360 missense probably damaging 1.00
R1579:Olfr653 UTSW 7 104580061 nonsense probably null
R1599:Olfr653 UTSW 7 104579648 start codon destroyed probably null
R1956:Olfr653 UTSW 7 104579909 missense probably damaging 1.00
R2134:Olfr653 UTSW 7 104579641 start gained probably benign
R2418:Olfr653 UTSW 7 104579934 missense probably benign 0.00
R2483:Olfr653 UTSW 7 104579942 missense probably damaging 1.00
R3623:Olfr653 UTSW 7 104579942 missense probably damaging 1.00
R4049:Olfr653 UTSW 7 104580368 missense probably benign
R4755:Olfr653 UTSW 7 104580061 nonsense probably null
R4757:Olfr653 UTSW 7 104580197 missense possibly damaging 0.95
R4828:Olfr653 UTSW 7 104579973 missense possibly damaging 0.62
R4842:Olfr653 UTSW 7 104580215 missense probably benign 0.45
R5496:Olfr653 UTSW 7 104580494 missense probably damaging 1.00
R6830:Olfr653 UTSW 7 104580240 missense probably damaging 1.00
R7320:Olfr653 UTSW 7 104580438 nonsense probably null
R7590:Olfr653 UTSW 7 104579942 missense probably damaging 1.00
RF020:Olfr653 UTSW 7 104580290 missense probably benign 0.00
Posted On2013-12-09