Incidental Mutation 'IGL01589:Olfr403'
ID91540
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr403
Ensembl Gene ENSMUSG00000070378
Gene Nameolfactory receptor 403
SynonymsMOR125-5_p, IA7, GA_x6K02T2P1NL-4348188-4349129
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.183) question?
Stock #IGL01589
Quality Score
Status
Chromosome11
Chromosomal Location74186249-74198612 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 74195761 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 86 (L86P)
Ref Sequence ENSEMBL: ENSMUSP00000145741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076675] [ENSMUST00000206114]
Predicted Effect probably damaging
Transcript: ENSMUST00000076675
AA Change: L86P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075971
Gene: ENSMUSG00000070378
AA Change: L86P

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7.3e-59 PFAM
Pfam:7tm_1 41 238 7.2e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206114
AA Change: L86P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206247
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,155,177 F307S probably damaging Het
Abcc6 A T 7: 46,002,672 probably benign Het
Adamts12 T A 15: 11,311,237 D1193E probably benign Het
Akap6 T A 12: 53,139,664 L1287H probably damaging Het
Ascl3 A G 7: 109,728,038 S25P probably benign Het
Brd2 A G 17: 34,117,042 S66P probably damaging Het
Cacna1i C A 15: 80,387,759 probably benign Het
Cdc5l T C 17: 45,404,676 Y670C probably damaging Het
Clybl T A 14: 122,371,422 I142N probably damaging Het
Cyp2c66 T C 19: 39,183,935 probably null Het
Dck C T 5: 88,774,236 probably benign Het
Dsg1b T C 18: 20,409,594 Y1053H probably damaging Het
Gm9912 T C 3: 149,185,350 D49G unknown Het
Gpr107 T C 2: 31,167,151 probably benign Het
Hsd3b7 T C 7: 127,802,864 F227S probably damaging Het
Lrrtm2 T A 18: 35,212,798 N484Y probably damaging Het
Muc19 A T 15: 91,870,501 noncoding transcript Het
Nodal G A 10: 61,418,397 R33Q probably benign Het
Plcb4 A G 2: 135,967,118 I569V probably benign Het
Plekhg1 T C 10: 3,963,631 Y1118H probably benign Het
Polr2a T G 11: 69,741,194 E1015D probably benign Het
Recql5 A G 11: 115,894,669 F667S probably damaging Het
Scube1 T C 15: 83,612,553 Y749C probably damaging Het
Serpinb1c C A 13: 32,886,172 V136F probably damaging Het
Slain2 T C 5: 72,941,446 probably benign Het
Slc10a7 T C 8: 78,729,740 S296P probably damaging Het
Sspo C T 6: 48,451,178 R320W probably damaging Het
Usp16 G A 16: 87,479,183 A469T probably benign Het
Vmn2r102 A T 17: 19,678,804 L469F probably benign Het
Zfp772 A G 7: 7,205,524 F107S possibly damaging Het
Other mutations in Olfr403
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01716:Olfr403 APN 11 74196381 missense probably benign 0.01
R0598:Olfr403 UTSW 11 74195832 missense possibly damaging 0.90
R1168:Olfr403 UTSW 11 74196421 missense probably benign
R1440:Olfr403 UTSW 11 74195679 missense probably damaging 1.00
R1657:Olfr403 UTSW 11 74195896 missense probably damaging 0.98
R1834:Olfr403 UTSW 11 74195653 missense probably benign 0.00
R1990:Olfr403 UTSW 11 74196163 missense probably damaging 0.99
R1991:Olfr403 UTSW 11 74196163 missense probably damaging 0.99
R2206:Olfr403 UTSW 11 74196324 missense possibly damaging 0.87
R2207:Olfr403 UTSW 11 74196324 missense possibly damaging 0.87
R3103:Olfr403 UTSW 11 74196075 missense probably benign 0.39
R4662:Olfr403 UTSW 11 74195716 missense probably damaging 1.00
R4844:Olfr403 UTSW 11 74196076 missense probably damaging 0.98
R5336:Olfr403 UTSW 11 74196033 missense probably damaging 1.00
R5918:Olfr403 UTSW 11 74196118 missense probably damaging 0.96
R6858:Olfr403 UTSW 11 74196099 missense probably benign 0.01
R7175:Olfr403 UTSW 11 74196178 nonsense probably null
R7362:Olfr403 UTSW 11 74195586 missense probably benign 0.01
R7670:Olfr403 UTSW 11 74196207 missense probably damaging 1.00
Posted On2013-12-09