Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01591:Commd10'

91588

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Commd10

Ensembl Gene

ENSMUSG00000042705

Gene Name

COMM domain containing 10

Synonyms

2310003A05Rik, DRWMS2

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01591

Quality Score

Status

Chromosome

Chromosomal Location

47091917-47242435 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 47096735 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 47 (S47R)

Ref Sequence

ENSEMBL: ENSMUSP00000041650 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049388]

AlphaFold

Q8JZY2

Predicted Effect

probably benign
Transcript: ENSMUST00000049388
AA Change: S47R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000041650
Gene: ENSMUSG00000042705
AA Change: S47R

Domain	Start	End	E-Value	Type
Pfam:HCaRG	21	200	6.8e-39	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	G	T	11: 84,134,146 (GRCm39)	G420W	probably damaging	Het
Adamts17	G	A	7: 66,654,144 (GRCm39)	R458H	probably damaging	Het
Adprs	T	C	4: 126,212,274 (GRCm39)	T82A	probably damaging	Het
Ccdc158	T	A	5: 92,809,900 (GRCm39)	I203L	probably benign	Het
Crb1	T	C	1: 139,165,077 (GRCm39)	T1016A	probably damaging	Het
Crhbp	T	A	13: 95,580,295 (GRCm39)	I95F	probably damaging	Het
Cyp3a11	A	T	5: 145,812,291 (GRCm39)		probably benign	Het
Dsel	A	G	1: 111,787,425 (GRCm39)	Y1037H	probably benign	Het
Epha1	T	C	6: 42,337,485 (GRCm39)	D898G	probably damaging	Het
Esr2	T	A	12: 76,168,498 (GRCm39)		probably benign	Het
Exosc10	T	A	4: 148,647,344 (GRCm39)		probably benign	Het
Fat4	A	T	3: 39,064,524 (GRCm39)	R4827*	probably null	Het
Gm11596	A	T	11: 99,683,624 (GRCm39)	C165*	probably null	Het
Heatr5b	A	G	17: 79,115,901 (GRCm39)	S852P	probably benign	Het
Mcm3ap	C	T	10: 76,306,639 (GRCm39)	P251S	probably benign	Het
Nmur2	A	G	11: 55,917,825 (GRCm39)	V388A	probably benign	Het
Parp14	T	C	16: 35,678,877 (GRCm39)	T364A	possibly damaging	Het
Rarb	T	A	14: 16,434,207 (GRCm38)	I370F	possibly damaging	Het
Rnf32	T	A	5: 29,429,272 (GRCm39)	I283N	probably damaging	Het
Smg8	A	G	11: 86,975,979 (GRCm39)	V77A	probably damaging	Het
Tnn	T	C	1: 159,953,144 (GRCm39)	E632G	probably damaging	Het
Trip11	A	T	12: 101,849,604 (GRCm39)	S1487T	probably damaging	Het
Vmn2r58	T	C	7: 41,514,753 (GRCm39)	K72R	probably benign	Het
Vmn2r92	A	G	17: 18,405,423 (GRCm39)	I856V	unknown	Het

Other mutations in Commd10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03162:Commd10	APN	18	47,220,117 (GRCm39)	missense	probably damaging	1.00
R0045:Commd10	UTSW	18	47,100,903 (GRCm39)	missense	possibly damaging	0.52
R1220:Commd10	UTSW	18	47,220,107 (GRCm39)	missense	probably damaging	0.98
R1735:Commd10	UTSW	18	47,123,552 (GRCm39)	missense	probably benign	0.18
R2049:Commd10	UTSW	18	47,096,814 (GRCm39)	missense	probably benign	0.03
R2135:Commd10	UTSW	18	47,123,604 (GRCm39)	missense	possibly damaging	0.70
R5330:Commd10	UTSW	18	47,093,497 (GRCm39)	missense	probably damaging	0.96
R5331:Commd10	UTSW	18	47,093,497 (GRCm39)	missense	probably damaging	0.96
R6250:Commd10	UTSW	18	47,096,755 (GRCm39)	missense	probably damaging	1.00
R7663:Commd10	UTSW	18	47,219,323 (GRCm39)	missense	probably benign
R7994:Commd10	UTSW	18	47,091,986 (GRCm39)	missense	possibly damaging	0.51
R8782:Commd10	UTSW	18	47,096,809 (GRCm39)	missense	probably damaging	1.00
Z1176:Commd10	UTSW	18	47,123,633 (GRCm39)	nonsense	probably null

Posted On

2013-12-09