Incidental Mutation 'IGL01593:Olfr1535'
ID91644
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1535
Ensembl Gene ENSMUSG00000054890
Gene Nameolfactory receptor 1535
SynonymsMOR256-36, Olfr1365, MOR256-63, GA_x6K02T2QHY8-11688984-11689964, MOR256-36
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL01593
Quality Score
Status
Chromosome13
Chromosomal Location21553894-21559893 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 21555219 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 268 (I268F)
Ref Sequence ENSEMBL: ENSMUSP00000149589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068163] [ENSMUST00000217519]
Predicted Effect probably damaging
Transcript: ENSMUST00000068163
AA Change: I268F

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000064142
Gene: ENSMUSG00000054890
AA Change: I268F

DomainStartEndE-ValueType
Pfam:7tm_4 31 320 5.4e-46 PFAM
Pfam:7tm_1 41 302 1.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217519
AA Change: I268F

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A T 8: 86,557,650 I310N probably damaging Het
Ackr4 C T 9: 104,085,931 probably benign Het
Ankib1 A T 5: 3,732,590 D346E probably benign Het
Armc4 T C 18: 7,127,345 K956R probably benign Het
Asap2 G T 12: 21,213,202 A273S probably null Het
Atp6v0d2 C A 4: 19,881,436 R219L probably damaging Het
Atp6v1e2 A T 17: 86,944,299 F224I probably damaging Het
Bnc2 T C 4: 84,276,241 probably null Het
Btbd11 T A 10: 85,654,475 probably benign Het
Cd33 A G 7: 43,530,281 L241P possibly damaging Het
Clec4g A T 8: 3,719,474 probably null Het
Dym C T 18: 75,114,781 probably benign Het
Enpp5 A G 17: 44,080,721 T14A probably benign Het
Ggt1 T C 10: 75,585,287 probably null Het
Gm17541 T A 12: 4,689,868 probably benign Het
Gpr39 A T 1: 125,677,451 I39F probably benign Het
Kcnb1 G T 2: 167,106,207 F240L probably damaging Het
Kcnt1 T A 2: 25,898,754 V400E probably damaging Het
Klhdc7a A G 4: 139,966,814 I274T probably damaging Het
Lrwd1 A T 5: 136,134,629 L71Q probably damaging Het
Mycbp2 A T 14: 103,291,287 probably null Het
Nckap1 A T 2: 80,520,570 M725K probably benign Het
Pole2 C T 12: 69,223,099 probably null Het
Prss32 A G 17: 23,856,008 T111A probably benign Het
Rgs9 A G 11: 109,249,049 probably benign Het
Slc2a4 A G 11: 69,944,828 C361R probably damaging Het
Ston1 G A 17: 88,637,010 G615R probably null Het
Tas2r139 T G 6: 42,140,957 W8G probably benign Het
Tmem101 A T 11: 102,155,878 L55Q probably damaging Het
Tnni3k T C 3: 154,941,029 probably null Het
Uba2 A G 7: 34,146,264 V478A probably damaging Het
Vps13a T C 19: 16,762,181 D52G probably damaging Het
Other mutations in Olfr1535
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01866:Olfr1535 APN 13 21555173 missense probably benign 0.07
IGL02289:Olfr1535 APN 13 21555588 missense probably benign 0.02
IGL02350:Olfr1535 APN 13 21555602 missense probably damaging 1.00
IGL02357:Olfr1535 APN 13 21555602 missense probably damaging 1.00
IGL02793:Olfr1535 APN 13 21556002 missense probably damaging 1.00
IGL02875:Olfr1535 APN 13 21556002 missense probably damaging 1.00
R0785:Olfr1535 UTSW 13 21555788 missense probably benign 0.02
R1773:Olfr1535 UTSW 13 21555812 missense probably damaging 1.00
R3429:Olfr1535 UTSW 13 21555805 nonsense probably null
R3430:Olfr1535 UTSW 13 21555805 nonsense probably null
R4232:Olfr1535 UTSW 13 21555461 missense probably damaging 0.98
R4883:Olfr1535 UTSW 13 21555488 missense probably benign 0.22
R5586:Olfr1535 UTSW 13 21555096 missense probably damaging 1.00
R6032:Olfr1535 UTSW 13 21555907 missense probably benign 0.01
R6032:Olfr1535 UTSW 13 21555907 missense probably benign 0.01
R6542:Olfr1535 UTSW 13 21555507 missense probably damaging 0.99
R7014:Olfr1535 UTSW 13 21555938 missense probably benign 0.02
R7579:Olfr1535 UTSW 13 21556006 missense probably benign 0.08
R7598:Olfr1535 UTSW 13 21555188 missense probably damaging 1.00
RF051:Olfr1535 UTSW 13 21555523 frame shift probably null
Posted On2013-12-09