Incidental Mutation 'IGL01593:Clec4g'
ID91668
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clec4g
Ensembl Gene ENSMUSG00000074491
Gene NameC-type lectin domain family 4, member g
Synonyms4930572L20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL01593
Quality Score
Status
Chromosome8
Chromosomal Location3707064-3720651 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 3719474 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000059574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058040] [ENSMUST00000062037]
Predicted Effect probably benign
Transcript: ENSMUST00000058040
Predicted Effect probably null
Transcript: ENSMUST00000062037
SMART Domains Protein: ENSMUSP00000059574
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
coiled coil region 98 153 N/A INTRINSIC
CLECT 165 288 8.85e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159612
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160490
Predicted Effect probably benign
Transcript: ENSMUST00000160527
SMART Domains Protein: ENSMUSP00000124493
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
CLECT 2 97 7.75e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A T 8: 86,557,650 I310N probably damaging Het
Ackr4 C T 9: 104,085,931 probably benign Het
Ankib1 A T 5: 3,732,590 D346E probably benign Het
Armc4 T C 18: 7,127,345 K956R probably benign Het
Asap2 G T 12: 21,213,202 A273S probably null Het
Atp6v0d2 C A 4: 19,881,436 R219L probably damaging Het
Atp6v1e2 A T 17: 86,944,299 F224I probably damaging Het
Bnc2 T C 4: 84,276,241 probably null Het
Btbd11 T A 10: 85,654,475 probably benign Het
Cd33 A G 7: 43,530,281 L241P possibly damaging Het
Dym C T 18: 75,114,781 probably benign Het
Enpp5 A G 17: 44,080,721 T14A probably benign Het
Ggt1 T C 10: 75,585,287 probably null Het
Gm17541 T A 12: 4,689,868 probably benign Het
Gpr39 A T 1: 125,677,451 I39F probably benign Het
Kcnb1 G T 2: 167,106,207 F240L probably damaging Het
Kcnt1 T A 2: 25,898,754 V400E probably damaging Het
Klhdc7a A G 4: 139,966,814 I274T probably damaging Het
Lrwd1 A T 5: 136,134,629 L71Q probably damaging Het
Mycbp2 A T 14: 103,291,287 probably null Het
Nckap1 A T 2: 80,520,570 M725K probably benign Het
Olfr1535 T A 13: 21,555,219 I268F probably damaging Het
Pole2 C T 12: 69,223,099 probably null Het
Prss32 A G 17: 23,856,008 T111A probably benign Het
Rgs9 A G 11: 109,249,049 probably benign Het
Slc2a4 A G 11: 69,944,828 C361R probably damaging Het
Ston1 G A 17: 88,637,010 G615R probably null Het
Tas2r139 T G 6: 42,140,957 W8G probably benign Het
Tmem101 A T 11: 102,155,878 L55Q probably damaging Het
Tnni3k T C 3: 154,941,029 probably null Het
Uba2 A G 7: 34,146,264 V478A probably damaging Het
Vps13a T C 19: 16,762,181 D52G probably damaging Het
Other mutations in Clec4g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Clec4g APN 8 3716410 intron probably benign
IGL01090:Clec4g APN 8 3719482 missense probably damaging 1.00
IGL01331:Clec4g APN 8 3717190 splice site probably benign
IGL02942:Clec4g APN 8 3718356 missense probably damaging 0.96
IGL03176:Clec4g APN 8 3718441 missense possibly damaging 0.90
R0071:Clec4g UTSW 8 3717489 start gained probably benign
R0379:Clec4g UTSW 8 3718440 missense probably benign 0.00
R4571:Clec4g UTSW 8 3718766 critical splice donor site probably null
R4854:Clec4g UTSW 8 3716534 missense probably damaging 1.00
R4856:Clec4g UTSW 8 3716419 intron probably benign
R4886:Clec4g UTSW 8 3716419 intron probably benign
R5370:Clec4g UTSW 8 3718344 missense probably benign 0.13
R5390:Clec4g UTSW 8 3718441 missense probably benign 0.02
R6522:Clec4g UTSW 8 3718803 missense probably benign 0.11
R6737:Clec4g UTSW 8 3707716 utr 3 prime probably benign
R7097:Clec4g UTSW 8 3719518 missense possibly damaging 0.58
Z1088:Clec4g UTSW 8 3707796 utr 3 prime probably benign
Z1088:Clec4g UTSW 8 3716548 missense probably damaging 1.00
Posted On2013-12-09