Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01594:Tex10'

91675

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex10

Ensembl Gene

ENSMUSG00000028345

Gene Name

testis expressed gene 10

Synonyms

clone 18330, 2810462N03Rik, 2610206N19Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.952) question?

Stock #

IGL01594

Quality Score

Status

Chromosome

Chromosomal Location

48430858-48473459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 48469906 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 53 (N53S)

Ref Sequence

ENSEMBL: ENSMUSP00000132498 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030030] [ENSMUST00000155905] [ENSMUST00000164866]

AlphaFold

Q3URQ0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000030030
AA Change: N53S

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000030030
Gene: ENSMUSG00000028345
AA Change: N53S

Domain	Start	End	E-Value	Type
low complexity region	13	25	N/A	INTRINSIC
Pfam:Ipi1_N	130	235	9.7e-24	PFAM
low complexity region	832	846	N/A	INTRINSIC
low complexity region	856	873	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132911

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155750

Predicted Effect

probably benign
Transcript: ENSMUST00000155905

SMART Domains

Protein: ENSMUSP00000114669
Gene: ENSMUSG00000028345

Domain	Start	End	E-Value	Type
Pfam:Ipi1_N	47	152	3.4e-24	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164866
AA Change: N53S

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000132498
Gene: ENSMUSG00000028345
AA Change: N53S

Domain	Start	End	E-Value	Type
low complexity region	13	25	N/A	INTRINSIC
Pfam:Ipi1_N	132	235	4.1e-25	PFAM
low complexity region	832	846	N/A	INTRINSIC
low complexity region	856	873	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E7.5 with impaired inner cell mass proliferation in culture. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb4	A	T	5: 8,996,071 (GRCm39)		probably null	Het
Acss1	A	T	2: 150,463,450 (GRCm39)	V618E	probably damaging	Het
Adgrg6	T	C	10: 14,310,084 (GRCm39)	N774D	probably damaging	Het
Atp9a	A	G	2: 168,532,932 (GRCm39)	V134A	probably damaging	Het
Csmd3	T	A	15: 47,492,635 (GRCm39)	T3169S	probably benign	Het
D030068K23Rik	T	A	8: 109,978,009 (GRCm39)	Q52L	unknown	Het
Dnah5	T	C	15: 28,311,480 (GRCm39)	S1820P	possibly damaging	Het
Fem1c	A	C	18: 46,639,343 (GRCm39)	S220A	probably benign	Het
Gm10305	G	A	4: 99,161,414 (GRCm39)	D108N	unknown	Het
Gtdc1	A	G	2: 44,481,891 (GRCm39)		probably null	Het
Il2ra	T	C	2: 11,685,207 (GRCm39)	V181A	possibly damaging	Het
Lrrn1	T	C	6: 107,544,454 (GRCm39)	I84T	probably damaging	Het
Map3k1	T	A	13: 111,894,723 (GRCm39)		probably null	Het
Mical1	T	G	10: 41,356,325 (GRCm39)	Y293D	probably damaging	Het
Mpzl1	T	C	1: 165,421,161 (GRCm39)	D266G	probably damaging	Het
Or55b4	C	A	7: 102,134,254 (GRCm39)	M24I	probably benign	Het
Pabpc4l	A	T	3: 46,401,581 (GRCm39)	V21D	probably damaging	Het
Prdm10	T	C	9: 31,258,149 (GRCm39)	C525R	probably damaging	Het
Ptprj	C	A	2: 90,271,139 (GRCm39)		probably benign	Het
Rgs3	T	C	4: 62,537,981 (GRCm39)	F4S	probably damaging	Het
Ryr3	G	A	2: 112,603,073 (GRCm39)	T2457I	probably damaging	Het
Scn3a	A	G	2: 65,291,775 (GRCm39)	I1657T	probably damaging	Het
Sema6a	A	G	18: 47,381,884 (GRCm39)	S888P	probably damaging	Het
Slc37a1	T	A	17: 31,538,122 (GRCm39)	Y148*	probably null	Het
Tyr	A	T	7: 87,133,022 (GRCm39)		probably benign	Het
Vmn2r100	A	G	17: 19,751,495 (GRCm39)	S513G	possibly damaging	Het

Other mutations in Tex10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00574:Tex10	APN	4	48,469,937 (GRCm39)	nonsense	probably null
IGL00832:Tex10	APN	4	48,468,864 (GRCm39)	missense	probably benign
IGL01376:Tex10	APN	4	48,456,740 (GRCm39)	missense	possibly damaging	0.90
IGL02754:Tex10	APN	4	48,435,028 (GRCm39)	missense	possibly damaging	0.46
IGL03071:Tex10	APN	4	48,452,946 (GRCm39)	missense	probably benign	0.00
IGL03399:Tex10	APN	4	48,459,915 (GRCm39)	missense	probably benign	0.04
R0105:Tex10	UTSW	4	48,468,957 (GRCm39)	missense	probably damaging	0.99
R0105:Tex10	UTSW	4	48,468,957 (GRCm39)	missense	probably damaging	0.99
R0544:Tex10	UTSW	4	48,462,766 (GRCm39)	splice site	probably null
R0583:Tex10	UTSW	4	48,451,952 (GRCm39)	missense	probably damaging	1.00
R0591:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R0592:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R0593:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R0893:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1485:Tex10	UTSW	4	48,436,492 (GRCm39)	missense	possibly damaging	0.54
R1703:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1704:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1706:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1911:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1912:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1930:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R1983:Tex10	UTSW	4	48,460,059 (GRCm39)	missense	possibly damaging	0.93
R2001:Tex10	UTSW	4	48,451,940 (GRCm39)	missense	probably damaging	1.00
R2074:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R2075:Tex10	UTSW	4	48,456,800 (GRCm39)	missense	probably benign	0.04
R2157:Tex10	UTSW	4	48,436,522 (GRCm39)	splice site	probably benign
R3000:Tex10	UTSW	4	48,459,393 (GRCm39)	splice site	probably null
R4067:Tex10	UTSW	4	48,459,355 (GRCm39)	nonsense	probably null
R4081:Tex10	UTSW	4	48,468,873 (GRCm39)	missense	probably benign	0.11
R4133:Tex10	UTSW	4	48,468,968 (GRCm39)	missense	probably damaging	1.00
R4352:Tex10	UTSW	4	48,452,039 (GRCm39)	missense	possibly damaging	0.77
R4364:Tex10	UTSW	4	48,468,774 (GRCm39)	missense	probably benign	0.13
R4601:Tex10	UTSW	4	48,452,946 (GRCm39)	missense	probably benign	0.00
R4602:Tex10	UTSW	4	48,452,946 (GRCm39)	missense	probably benign	0.00
R4610:Tex10	UTSW	4	48,452,946 (GRCm39)	missense	probably benign	0.00
R4707:Tex10	UTSW	4	48,468,984 (GRCm39)	missense	probably benign	0.00
R4744:Tex10	UTSW	4	48,469,990 (GRCm39)	missense	probably benign	0.00
R4778:Tex10	UTSW	4	48,436,468 (GRCm39)	missense	probably damaging	1.00
R4989:Tex10	UTSW	4	48,458,525 (GRCm39)	splice site	probably benign
R5051:Tex10	UTSW	4	48,460,019 (GRCm39)	missense	possibly damaging	0.86
R5120:Tex10	UTSW	4	48,459,272 (GRCm39)	missense	possibly damaging	0.68
R5732:Tex10	UTSW	4	48,460,046 (GRCm39)	missense	probably damaging	1.00
R5799:Tex10	UTSW	4	48,433,295 (GRCm39)	missense	possibly damaging	0.62
R5813:Tex10	UTSW	4	48,452,928 (GRCm39)	missense	probably benign	0.00
R6091:Tex10	UTSW	4	48,459,891 (GRCm39)	missense	probably damaging	0.98
R6223:Tex10	UTSW	4	48,468,525 (GRCm39)	missense	probably damaging	0.98
R6493:Tex10	UTSW	4	48,436,450 (GRCm39)	missense	probably damaging	1.00
R7567:Tex10	UTSW	4	48,468,787 (GRCm39)	missense	possibly damaging	0.93
R7590:Tex10	UTSW	4	48,467,725 (GRCm39)	missense	probably damaging	0.99
R7808:Tex10	UTSW	4	48,459,984 (GRCm39)	missense	probably benign
R8004:Tex10	UTSW	4	48,452,047 (GRCm39)	missense	possibly damaging	0.64
R8084:Tex10	UTSW	4	48,431,066 (GRCm39)	missense	probably benign	0.05
R9030:Tex10	UTSW	4	48,452,056 (GRCm39)	missense	probably damaging	1.00
X0017:Tex10	UTSW	4	48,460,080 (GRCm39)	missense	probably benign	0.00

Posted On

2013-12-09