Incidental Mutation 'IGL01594:Olfr544'
ID91692
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr544
Ensembl Gene ENSMUSG00000043925
Gene Nameolfactory receptor 544
SynonymsGA_x6K02T2PBJ9-5206624-5205620, MOR42-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL01594
Quality Score
Status
Chromosome7
Chromosomal Location102482031-102488313 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 102485047 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 24 (M24I)
Ref Sequence ENSEMBL: ENSMUSP00000051280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051201] [ENSMUST00000219647]
Predicted Effect probably benign
Transcript: ENSMUST00000051201
AA Change: M24I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000051280
Gene: ENSMUSG00000043925
AA Change: M24I

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.2e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 6.3e-8 PFAM
Pfam:7tm_1 45 296 2.4e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219647
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,946,071 probably null Het
Acss1 A T 2: 150,621,530 V618E probably damaging Het
Adgrg6 T C 10: 14,434,340 N774D probably damaging Het
Atp9a A G 2: 168,691,012 V134A probably damaging Het
Csmd3 T A 15: 47,629,239 T3169S probably benign Het
D030068K23Rik T A 8: 109,251,377 Q52L unknown Het
Dnah5 T C 15: 28,311,334 S1820P possibly damaging Het
Fem1c A C 18: 46,506,276 S220A probably benign Het
Gm10305 G A 4: 99,273,177 D108N unknown Het
Gtdc1 A G 2: 44,591,879 probably null Het
Il2ra T C 2: 11,680,396 V181A possibly damaging Het
Lrrn1 T C 6: 107,567,493 I84T probably damaging Het
Map3k1 T A 13: 111,758,189 probably null Het
Mical1 T G 10: 41,480,329 Y293D probably damaging Het
Mpzl1 T C 1: 165,593,592 D266G probably damaging Het
Pabpc4l A T 3: 46,447,146 V21D probably damaging Het
Prdm10 T C 9: 31,346,853 C525R probably damaging Het
Ptprj C A 2: 90,440,795 probably benign Het
Rgs3 T C 4: 62,619,744 F4S probably damaging Het
Ryr3 G A 2: 112,772,728 T2457I probably damaging Het
Scn3a A G 2: 65,461,431 I1657T probably damaging Het
Sema6a A G 18: 47,248,817 S888P probably damaging Het
Slc37a1 T A 17: 31,319,148 Y148* probably null Het
Tex10 T C 4: 48,469,906 N53S possibly damaging Het
Tyr A T 7: 87,483,814 probably benign Het
Vmn2r100 A G 17: 19,531,233 S513G possibly damaging Het
Other mutations in Olfr544
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Olfr544 APN 7 102484478 missense probably damaging 1.00
IGL01380:Olfr544 APN 7 102484385 missense probably damaging 1.00
R0732:Olfr544 UTSW 7 102484443 missense probably benign 0.15
R1061:Olfr544 UTSW 7 102484114 makesense probably null
R1387:Olfr544 UTSW 7 102484704 missense probably benign 0.01
R2760:Olfr544 UTSW 7 102484376 missense probably damaging 1.00
R5151:Olfr544 UTSW 7 102484985 missense probably benign 0.00
R5916:Olfr544 UTSW 7 102484379 missense probably damaging 1.00
R6084:Olfr544 UTSW 7 102484389 missense probably damaging 1.00
R7069:Olfr544 UTSW 7 102484772 missense possibly damaging 0.85
R7195:Olfr544 UTSW 7 102484367 missense probably damaging 1.00
R7738:Olfr544 UTSW 7 102484611 missense probably damaging 0.99
R8299:Olfr544 UTSW 7 102484202 missense probably benign 0.01
Posted On2013-12-09