Incidental Mutation 'IGL01597:Taar8a'
ID91706
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Taar8a
Ensembl Gene ENSMUSG00000096442
Gene Nametrace amine-associated receptor 8A
SynonymsLOC215859
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.121) question?
Stock #IGL01597
Quality Score
Status
Chromosome10
Chromosomal Location24076500-24077534 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 24076858 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 120 (L120P)
Ref Sequence ENSEMBL: ENSMUSP00000062719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051133]
Predicted Effect possibly damaging
Transcript: ENSMUST00000051133
AA Change: L120P

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000062719
Gene: ENSMUSG00000096442
AA Change: L120P

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 40 244 3.9e-8 PFAM
Pfam:7TM_GPCR_Srsx 42 327 7.1e-15 PFAM
Pfam:7tm_1 48 312 9.1e-58 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cacna2d1 A T 5: 16,326,392 probably benign Het
Cdk12 A G 11: 98,250,264 probably benign Het
Ces1e T A 8: 93,210,373 I357F probably benign Het
Dicer1 G A 12: 104,705,210 R934* probably null Het
Dnah9 A T 11: 66,118,830 Y744N probably damaging Het
Fgd5 T A 6: 91,987,929 I381N probably damaging Het
Gabrg1 T C 5: 70,782,348 D147G probably damaging Het
Gpsm2 A T 3: 108,696,987 M385K probably benign Het
Hivep2 C T 10: 14,149,374 Q2311* probably null Het
Olfr368 A C 2: 37,332,011 D88A possibly damaging Het
Olfr615 A G 7: 103,561,142 I222V possibly damaging Het
Olfr64 A G 7: 103,893,096 V213A probably benign Het
Olfr866 A T 9: 20,027,686 M84K probably damaging Het
Papss2 G A 19: 32,638,258 R130H probably damaging Het
Pik3r5 A T 11: 68,496,001 I819F probably damaging Het
Pipox A G 11: 77,883,193 V199A probably damaging Het
Pkd1l3 G T 8: 109,623,521 V333L probably benign Het
Rbl1 A G 2: 157,195,449 probably benign Het
Scyl2 T A 10: 89,652,987 I489F probably damaging Het
Serinc4 T A 2: 121,454,991 L100F probably damaging Het
Slc39a12 T A 2: 14,434,309 F458Y possibly damaging Het
Snrnp200 T C 2: 127,238,732 probably benign Het
Syngr4 T C 7: 45,886,966 T211A probably benign Het
Tbx10 A G 19: 3,996,736 K72R probably benign Het
Tomm70a A G 16: 57,133,188 T149A probably benign Het
Traip T A 9: 107,955,924 probably null Het
Trpm3 G A 19: 22,715,246 G234R probably damaging Het
Tubgcp5 A G 7: 55,806,832 probably benign Het
Vstm5 T C 9: 15,257,379 W80R probably damaging Het
Vwa5a A T 9: 38,733,865 R415S probably damaging Het
Zfp39 A G 11: 58,891,543 V131A probably damaging Het
Other mutations in Taar8a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Taar8a APN 10 24076861 missense probably damaging 1.00
IGL01546:Taar8a APN 10 24076915 missense possibly damaging 0.95
IGL02387:Taar8a APN 10 24077362 missense possibly damaging 0.93
IGL02815:Taar8a APN 10 24077380 missense probably benign 0.02
R0762:Taar8a UTSW 10 24077077 missense probably benign 0.34
R1690:Taar8a UTSW 10 24076915 missense probably damaging 1.00
R2891:Taar8a UTSW 10 24077130 missense probably benign 0.02
R3889:Taar8a UTSW 10 24077025 missense probably benign 0.00
R3962:Taar8a UTSW 10 24077156 missense probably damaging 0.99
R4090:Taar8a UTSW 10 24077164 missense probably damaging 0.96
R6580:Taar8a UTSW 10 24076893 missense probably damaging 0.99
R6605:Taar8a UTSW 10 24076776 missense possibly damaging 0.88
R7422:Taar8a UTSW 10 24076864 missense probably damaging 1.00
R7571:Taar8a UTSW 10 24077408 nonsense probably null
R8265:Taar8a UTSW 10 24076941 missense probably damaging 1.00
X0022:Taar8a UTSW 10 24077508 missense possibly damaging 0.93
X0062:Taar8a UTSW 10 24077381 nonsense probably null
Posted On2013-12-09