Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01597:Vstm5'

91719

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vstm5

Ensembl Gene

ENSMUSG00000031937

Gene Name

V-set and transmembrane domain containing 5

Synonyms

2200002K05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL01597

Quality Score

Status

Chromosome

Chromosomal Location

15150341-15170712 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 15168675 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 80 (W80R)

Ref Sequence

ENSEMBL: ENSMUSP00000034413 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034411] [ENSMUST00000034413] [ENSMUST00000213788]

AlphaFold

Q9D806

Predicted Effect

probably benign
Transcript: ENSMUST00000034411

SMART Domains

Protein: ENSMUSP00000034411
Gene: ENSMUSG00000031935

Domain	Start	End	E-Value	Type
low complexity region	51	82	N/A	INTRINSIC
Pfam:Med17	123	452	8.5e-13	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000034413
AA Change: W80R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000034413
Gene: ENSMUSG00000031937
AA Change: W80R

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
IG	39	138	2e-3	SMART
transmembrane domain	147	169	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000213788

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cacna2d1	A	T	5: 16,531,390 (GRCm39)		probably benign	Het
Cdk12	A	G	11: 98,141,090 (GRCm39)		probably benign	Het
Ces1e	T	A	8: 93,937,001 (GRCm39)	I357F	probably benign	Het
Dicer1	G	A	12: 104,671,469 (GRCm39)	R934*	probably null	Het
Dnah9	A	T	11: 66,009,656 (GRCm39)	Y744N	probably damaging	Het
Fgd5	T	A	6: 91,964,910 (GRCm39)	I381N	probably damaging	Het
Gabrg1	T	C	5: 70,939,691 (GRCm39)	D147G	probably damaging	Het
Gpsm2	A	T	3: 108,604,303 (GRCm39)	M385K	probably benign	Het
Hivep2	C	T	10: 14,025,118 (GRCm39)	Q2311*	probably null	Het
Or51ah3	A	G	7: 103,210,349 (GRCm39)	I222V	possibly damaging	Het
Or51b17	A	G	7: 103,542,303 (GRCm39)	V213A	probably benign	Het
Or5c1	A	C	2: 37,222,023 (GRCm39)	D88A	possibly damaging	Het
Or7e173	A	T	9: 19,938,982 (GRCm39)	M84K	probably damaging	Het
Papss2	G	A	19: 32,615,658 (GRCm39)	R130H	probably damaging	Het
Pik3r5	A	T	11: 68,386,827 (GRCm39)	I819F	probably damaging	Het
Pipox	A	G	11: 77,774,019 (GRCm39)	V199A	probably damaging	Het
Pkd1l3	G	T	8: 110,350,153 (GRCm39)	V333L	probably benign	Het
Rbl1	A	G	2: 157,037,369 (GRCm39)		probably benign	Het
Scyl2	T	A	10: 89,488,849 (GRCm39)	I489F	probably damaging	Het
Serinc4	T	A	2: 121,285,472 (GRCm39)	L100F	probably damaging	Het
Slc39a12	T	A	2: 14,439,120 (GRCm39)	F458Y	possibly damaging	Het
Snrnp200	T	C	2: 127,080,652 (GRCm39)		probably benign	Het
Syngr4	T	C	7: 45,536,390 (GRCm39)	T211A	probably benign	Het
Taar8a	T	C	10: 23,952,756 (GRCm39)	L120P	possibly damaging	Het
Tbx10	A	G	19: 4,046,736 (GRCm39)	K72R	probably benign	Het
Tomm70a	A	G	16: 56,953,551 (GRCm39)	T149A	probably benign	Het
Traip	T	A	9: 107,833,123 (GRCm39)		probably null	Het
Trpm3	G	A	19: 22,692,610 (GRCm39)	G234R	probably damaging	Het
Tubgcp5	A	G	7: 55,456,580 (GRCm39)		probably benign	Het
Vwa5a	A	T	9: 38,645,161 (GRCm39)	R415S	probably damaging	Het
Zfp39	A	G	11: 58,782,369 (GRCm39)	V131A	probably damaging	Het

Other mutations in Vstm5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01781:Vstm5	APN	9	15,168,968 (GRCm39)	missense	probably damaging	1.00
IGL02940:Vstm5	APN	9	15,168,962 (GRCm39)	missense	probably damaging	1.00
R1155:Vstm5	UTSW	9	15,168,849 (GRCm39)	missense	probably damaging	1.00
R1721:Vstm5	UTSW	9	15,168,663 (GRCm39)	missense	probably benign	0.13
R2368:Vstm5	UTSW	9	15,169,027 (GRCm39)	missense	probably benign	0.00
R3160:Vstm5	UTSW	9	15,168,594 (GRCm39)	missense	probably benign	0.02
R3161:Vstm5	UTSW	9	15,168,594 (GRCm39)	missense	probably benign	0.02
R3162:Vstm5	UTSW	9	15,168,594 (GRCm39)	missense	probably benign	0.02
R4612:Vstm5	UTSW	9	15,168,789 (GRCm39)	missense	probably benign	0.22
R4692:Vstm5	UTSW	9	15,168,718 (GRCm39)	missense	probably damaging	0.99
R4950:Vstm5	UTSW	9	15,169,090 (GRCm39)	splice site	probably null
R5088:Vstm5	UTSW	9	15,168,601 (GRCm39)	missense	possibly damaging	0.87
R6351:Vstm5	UTSW	9	15,168,829 (GRCm39)	missense	probably damaging	1.00
R7063:Vstm5	UTSW	9	15,150,549 (GRCm39)	start gained	probably benign
R7720:Vstm5	UTSW	9	15,150,652 (GRCm39)	missense	probably benign	0.08
R9300:Vstm5	UTSW	9	15,168,585 (GRCm39)	missense	probably damaging	1.00
R9491:Vstm5	UTSW	9	15,168,586 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-12-09