Incidental Mutation 'IGL01597:Vstm5'
ID91719
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vstm5
Ensembl Gene ENSMUSG00000031937
Gene NameV-set and transmembrane domain containing 5
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL01597
Quality Score
Status
Chromosome9
Chromosomal Location15239045-15259416 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 15257379 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 80 (W80R)
Ref Sequence ENSEMBL: ENSMUSP00000034413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034411] [ENSMUST00000034413] [ENSMUST00000213788]
Predicted Effect probably benign
Transcript: ENSMUST00000034411
SMART Domains Protein: ENSMUSP00000034411
Gene: ENSMUSG00000031935

DomainStartEndE-ValueType
low complexity region 51 82 N/A INTRINSIC
Pfam:Med17 123 452 8.5e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000034413
AA Change: W80R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034413
Gene: ENSMUSG00000031937
AA Change: W80R

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
IG 39 138 2e-3 SMART
transmembrane domain 147 169 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213788
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cacna2d1 A T 5: 16,326,392 probably benign Het
Cdk12 A G 11: 98,250,264 probably benign Het
Ces1e T A 8: 93,210,373 I357F probably benign Het
Dicer1 G A 12: 104,705,210 R934* probably null Het
Dnah9 A T 11: 66,118,830 Y744N probably damaging Het
Fgd5 T A 6: 91,987,929 I381N probably damaging Het
Gabrg1 T C 5: 70,782,348 D147G probably damaging Het
Gpsm2 A T 3: 108,696,987 M385K probably benign Het
Hivep2 C T 10: 14,149,374 Q2311* probably null Het
Olfr368 A C 2: 37,332,011 D88A possibly damaging Het
Olfr615 A G 7: 103,561,142 I222V possibly damaging Het
Olfr64 A G 7: 103,893,096 V213A probably benign Het
Olfr866 A T 9: 20,027,686 M84K probably damaging Het
Papss2 G A 19: 32,638,258 R130H probably damaging Het
Pik3r5 A T 11: 68,496,001 I819F probably damaging Het
Pipox A G 11: 77,883,193 V199A probably damaging Het
Pkd1l3 G T 8: 109,623,521 V333L probably benign Het
Rbl1 A G 2: 157,195,449 probably benign Het
Scyl2 T A 10: 89,652,987 I489F probably damaging Het
Serinc4 T A 2: 121,454,991 L100F probably damaging Het
Slc39a12 T A 2: 14,434,309 F458Y possibly damaging Het
Snrnp200 T C 2: 127,238,732 probably benign Het
Syngr4 T C 7: 45,886,966 T211A probably benign Het
Taar8a T C 10: 24,076,858 L120P possibly damaging Het
Tbx10 A G 19: 3,996,736 K72R probably benign Het
Tomm70a A G 16: 57,133,188 T149A probably benign Het
Traip T A 9: 107,955,924 probably null Het
Trpm3 G A 19: 22,715,246 G234R probably damaging Het
Tubgcp5 A G 7: 55,806,832 probably benign Het
Vwa5a A T 9: 38,733,865 R415S probably damaging Het
Zfp39 A G 11: 58,891,543 V131A probably damaging Het
Other mutations in Vstm5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01781:Vstm5 APN 9 15257672 missense probably damaging 1.00
IGL02940:Vstm5 APN 9 15257666 missense probably damaging 1.00
R1155:Vstm5 UTSW 9 15257553 missense probably damaging 1.00
R1721:Vstm5 UTSW 9 15257367 missense probably benign 0.13
R2368:Vstm5 UTSW 9 15257731 missense probably benign 0.00
R3160:Vstm5 UTSW 9 15257298 missense probably benign 0.02
R3161:Vstm5 UTSW 9 15257298 missense probably benign 0.02
R3162:Vstm5 UTSW 9 15257298 missense probably benign 0.02
R4612:Vstm5 UTSW 9 15257493 missense probably benign 0.22
R4692:Vstm5 UTSW 9 15257422 missense probably damaging 0.99
R4950:Vstm5 UTSW 9 15257794 splice site probably null
R5088:Vstm5 UTSW 9 15257305 missense possibly damaging 0.87
R6351:Vstm5 UTSW 9 15257533 missense probably damaging 1.00
R7063:Vstm5 UTSW 9 15239253 start gained probably benign
R7720:Vstm5 UTSW 9 15239356 missense probably benign 0.08
Posted On2013-12-09