Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01598:Zbtb26'

91743

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zbtb26

Ensembl Gene

ENSMUSG00000050714

Gene Name

zinc finger and BTB domain containing 26

Synonyms

A630026F21Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.429) question?

Stock #

IGL01598

Quality Score

Status

Chromosome

Chromosomal Location

37432168-37443135 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 37436271 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 251 (Y251C)

Ref Sequence

ENSEMBL: ENSMUSP00000099850 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067043] [ENSMUST00000102789] [ENSMUST00000112932]

AlphaFold

Q8C8S0

Predicted Effect

probably damaging
Transcript: ENSMUST00000067043
AA Change: Y240C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000070071
Gene: ENSMUSG00000050714
AA Change: Y240C

Domain	Start	End	E-Value	Type
BTB	33	127	4.38e-12	SMART
low complexity region	169	179	N/A	INTRINSIC
ZnF_C2H2	273	295	1.36e-2	SMART
ZnF_C2H2	298	320	1.4e-4	SMART
ZnF_C2H2	326	348	2.99e-4	SMART
ZnF_C2H2	354	377	2.09e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000102789
AA Change: Y251C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000099850
Gene: ENSMUSG00000050714
AA Change: Y251C

Domain	Start	End	E-Value	Type
BTB	44	138	4.38e-12	SMART
low complexity region	180	190	N/A	INTRINSIC
ZnF_C2H2	284	306	1.36e-2	SMART
ZnF_C2H2	309	331	1.4e-4	SMART
ZnF_C2H2	337	359	2.99e-4	SMART
ZnF_C2H2	365	388	2.09e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112932

SMART Domains

Protein: ENSMUSP00000108554
Gene: ENSMUSG00000066798

Domain	Start	End	E-Value	Type
BTB	33	127	2.67e-16	SMART
Blast:BTB	161	196	1e-5	BLAST
ZnF_C2H2	300	322	7.15e-2	SMART
ZnF_C2H2	325	347	1.58e-3	SMART
ZnF_C2H2	353	375	3.63e-3	SMART
ZnF_C2H2	381	404	8.81e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203522

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410124H12Rik	T	A	16: 92,478,929		noncoding transcript	Het
Apc2	T	A	10: 80,313,048	L1283Q	probably damaging	Het
Apol6	G	A	15: 77,050,716	A62T	probably damaging	Het
AU018091	A	T	7: 3,162,270	I204N	possibly damaging	Het
B4galnt4	G	T	7: 141,070,515	R765L	probably benign	Het
Brca1	T	C	11: 101,524,330	T993A	probably benign	Het
Cadps	C	T	14: 12,522,202		probably null	Het
Ccdc177	A	G	12: 80,758,745	S252P	unknown	Het
Cdc73	A	G	1: 143,699,279	S59P	probably damaging	Het
Cep63	G	T	9: 102,590,458	Q570K	possibly damaging	Het
Ces1c	A	T	8: 93,118,413	I120K	probably benign	Het
Cpeb1	T	C	7: 81,361,801	M131V	probably benign	Het
Dync1h1	G	A	12: 110,658,128	V3701I	probably damaging	Het
Fxr1	T	C	3: 34,064,232	S535P	possibly damaging	Het
Gldc	A	T	19: 30,133,756	V540D	probably damaging	Het
Iqcf6	A	G	9: 106,627,508	T124A	probably benign	Het
Itih4	A	G	14: 30,887,817	I35V	possibly damaging	Het
Kmt2c	T	C	5: 25,273,666	*1525W	probably null	Het
Kmt2c	A	T	5: 25,354,771	V963E	probably damaging	Het
Lmnb2	T	C	10: 80,907,165	S202G	probably benign	Het
Med23	T	G	10: 24,903,798	S924R	probably benign	Het
Olfr1454	T	C	19: 13,064,149	V246A	probably damaging	Het
Pcif1	T	C	2: 164,886,611	F263L	possibly damaging	Het
Pon2	A	T	6: 5,272,331	L163H	probably damaging	Het
Scn1a	C	T	2: 66,302,485	V165M	possibly damaging	Het
Sema6d	C	A	2: 124,665,098	P961Q	probably damaging	Het
Snx27	A	G	3: 94,561,843	Y64H	probably damaging	Het
Srsf11	C	T	3: 158,012,035		probably benign	Het
Taok1	A	G	11: 77,571,684	V193A	probably damaging	Het
Vps13d	T	C	4: 145,016,901	T4137A	probably benign	Het
Zcchc11	A	G	4: 108,550,820		probably benign	Het

Other mutations in Zbtb26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00579:Zbtb26	APN	2	37436442	missense	possibly damaging	0.82
IGL00899:Zbtb26	APN	2	37436258	nonsense	probably null
IGL01940:Zbtb26	APN	2	37435975	missense	possibly damaging	0.93
IGL02152:Zbtb26	APN	2	37436691	missense	possibly damaging	0.95
IGL02867:Zbtb26	APN	2	37436249	missense	probably benign	0.00
IGL02889:Zbtb26	APN	2	37436249	missense	probably benign	0.00
IGL03081:Zbtb26	APN	2	37436600	missense	possibly damaging	0.67
R0138:Zbtb26	UTSW	2	37436041	missense	probably benign	0.16
R0328:Zbtb26	UTSW	2	37436795	missense	possibly damaging	0.81
R0927:Zbtb26	UTSW	2	37436325	missense	possibly damaging	0.91
R1671:Zbtb26	UTSW	2	37436365	missense	probably benign	0.00
R1813:Zbtb26	UTSW	2	37436335	missense	possibly damaging	0.68
R1896:Zbtb26	UTSW	2	37436335	missense	possibly damaging	0.68
R2128:Zbtb26	UTSW	2	37436551	missense	probably benign	0.00
R2374:Zbtb26	UTSW	2	37436485	missense	probably benign
R4050:Zbtb26	UTSW	2	37436988	start codon destroyed	probably null	0.46
R4631:Zbtb26	UTSW	2	37436956	missense	probably benign	0.00
R4940:Zbtb26	UTSW	2	37436769	missense	probably damaging	0.98
R5071:Zbtb26	UTSW	2	37435929	missense	probably benign	0.26
R6348:Zbtb26	UTSW	2	37435675	missense	probably benign	0.43
R6962:Zbtb26	UTSW	2	37436094	missense	possibly damaging	0.71
R6990:Zbtb26	UTSW	2	37436545	missense	probably benign	0.00
R7261:Zbtb26	UTSW	2	37436655	missense	possibly damaging	0.71
R7981:Zbtb26	UTSW	2	37436875	missense	possibly damaging	0.51
R8013:Zbtb26	UTSW	2	37437001	critical splice acceptor site	probably null
R8014:Zbtb26	UTSW	2	37437001	critical splice acceptor site	probably null
R8872:Zbtb26	UTSW	2	37436901	missense	probably damaging	0.99
R8876:Zbtb26	UTSW	2	37436884	missense	probably benign
R8905:Zbtb26	UTSW	2	37436915	missense	probably benign	0.00

Posted On

2013-12-09