Incidental Mutation 'IGL01598:Ccdc177'
ID91748
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccdc177
Ensembl Gene ENSMUSG00000062961
Gene Namecoiled-coil domain containing 177
SynonymsGm1568, LOC380768
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL01598
Quality Score
Status
Chromosome12
Chromosomal Location80754043-80760687 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 80758745 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 252 (S252P)
Ref Sequence ENSEMBL: ENSMUSP00000072982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073251]
Predicted Effect unknown
Transcript: ENSMUST00000073251
AA Change: S252P
SMART Domains Protein: ENSMUSP00000072982
Gene: ENSMUSG00000062961
AA Change: S252P

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
low complexity region 28 49 N/A INTRINSIC
internal_repeat_1 116 139 2.91e-5 PROSPERO
low complexity region 146 159 N/A INTRINSIC
low complexity region 165 227 N/A INTRINSIC
low complexity region 229 263 N/A INTRINSIC
Pfam:DUF4659 332 705 1.9e-115 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181092
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410124H12Rik T A 16: 92,478,929 noncoding transcript Het
Apc2 T A 10: 80,313,048 L1283Q probably damaging Het
Apol6 G A 15: 77,050,716 A62T probably damaging Het
AU018091 A T 7: 3,162,270 I204N possibly damaging Het
B4galnt4 G T 7: 141,070,515 R765L probably benign Het
Brca1 T C 11: 101,524,330 T993A probably benign Het
Cadps C T 14: 12,522,202 probably null Het
Cdc73 A G 1: 143,699,279 S59P probably damaging Het
Cep63 G T 9: 102,590,458 Q570K possibly damaging Het
Ces1c A T 8: 93,118,413 I120K probably benign Het
Cpeb1 T C 7: 81,361,801 M131V probably benign Het
Dync1h1 G A 12: 110,658,128 V3701I probably damaging Het
Fxr1 T C 3: 34,064,232 S535P possibly damaging Het
Gldc A T 19: 30,133,756 V540D probably damaging Het
Iqcf6 A G 9: 106,627,508 T124A probably benign Het
Itih4 A G 14: 30,887,817 I35V possibly damaging Het
Kmt2c T C 5: 25,273,666 *1525W probably null Het
Kmt2c A T 5: 25,354,771 V963E probably damaging Het
Lmnb2 T C 10: 80,907,165 S202G probably benign Het
Med23 T G 10: 24,903,798 S924R probably benign Het
Olfr1454 T C 19: 13,064,149 V246A probably damaging Het
Pcif1 T C 2: 164,886,611 F263L possibly damaging Het
Pon2 A T 6: 5,272,331 L163H probably damaging Het
Scn1a C T 2: 66,302,485 V165M possibly damaging Het
Sema6d C A 2: 124,665,098 P961Q probably damaging Het
Snx27 A G 3: 94,561,843 Y64H probably damaging Het
Srsf11 C T 3: 158,012,035 probably benign Het
Taok1 A G 11: 77,571,684 V193A probably damaging Het
Vps13d T C 4: 145,016,901 T4137A probably benign Het
Zbtb26 T C 2: 37,436,271 Y251C probably damaging Het
Zcchc11 A G 4: 108,550,820 probably benign Het
Other mutations in Ccdc177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02433:Ccdc177 APN 12 80757598 missense unknown
R0829:Ccdc177 UTSW 12 80759479 missense probably damaging 0.96
R1739:Ccdc177 UTSW 12 80759239 missense probably damaging 1.00
R1970:Ccdc177 UTSW 12 80758712 missense unknown
R2337:Ccdc177 UTSW 12 80758691 missense unknown
R5001:Ccdc177 UTSW 12 80757386 missense unknown
R5164:Ccdc177 UTSW 12 80758562 missense unknown
R5249:Ccdc177 UTSW 12 80758508 missense unknown
R5461:Ccdc177 UTSW 12 80758042 missense unknown
R6802:Ccdc177 UTSW 12 80759283 missense probably damaging 1.00
R7051:Ccdc177 UTSW 12 80759153 missense probably damaging 0.98
R7412:Ccdc177 UTSW 12 80759018 missense possibly damaging 0.85
R7510:Ccdc177 UTSW 12 80757683 missense unknown
R7511:Ccdc177 UTSW 12 80757683 missense unknown
R7712:Ccdc177 UTSW 12 80757938 nonsense probably null
R8036:Ccdc177 UTSW 12 80758123 missense unknown
R8693:Ccdc177 UTSW 12 80757808 missense unknown
R8708:Ccdc177 UTSW 12 80759117 missense probably benign 0.08
R8862:Ccdc177 UTSW 12 80757434 missense unknown
R8894:Ccdc177 UTSW 12 80759303 missense probably damaging 1.00
Z1177:Ccdc177 UTSW 12 80757736 missense unknown
Posted On2013-12-09