Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01598:Ccdc177'

91748

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccdc177

Ensembl Gene

ENSMUSG00000062961

Gene Name

coiled-coil domain containing 177

Synonyms

Gm1568, LOC380768

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

IGL01598

Quality Score

Status

Chromosome

Chromosomal Location

80754043-80760687 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 80758745 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 252 (S252P)

Ref Sequence

ENSEMBL: ENSMUSP00000072982 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073251]

AlphaFold

Q3UHB8

Predicted Effect

unknown
Transcript: ENSMUST00000073251
AA Change: S252P

SMART Domains

Protein: ENSMUSP00000072982
Gene: ENSMUSG00000062961
AA Change: S252P

Domain	Start	End	E-Value	Type
low complexity region	7	20	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
internal_repeat_1	116	139	2.91e-5	PROSPERO
low complexity region	146	159	N/A	INTRINSIC
low complexity region	165	227	N/A	INTRINSIC
low complexity region	229	263	N/A	INTRINSIC
Pfam:DUF4659	332	705	1.9e-115	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181092

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410124H12Rik	T	A	16: 92,478,929		noncoding transcript	Het
Apc2	T	A	10: 80,313,048	L1283Q	probably damaging	Het
Apol6	G	A	15: 77,050,716	A62T	probably damaging	Het
AU018091	A	T	7: 3,162,270	I204N	possibly damaging	Het
B4galnt4	G	T	7: 141,070,515	R765L	probably benign	Het
Brca1	T	C	11: 101,524,330	T993A	probably benign	Het
Cadps	C	T	14: 12,522,202		probably null	Het
Cdc73	A	G	1: 143,699,279	S59P	probably damaging	Het
Cep63	G	T	9: 102,590,458	Q570K	possibly damaging	Het
Ces1c	A	T	8: 93,118,413	I120K	probably benign	Het
Cpeb1	T	C	7: 81,361,801	M131V	probably benign	Het
Dync1h1	G	A	12: 110,658,128	V3701I	probably damaging	Het
Fxr1	T	C	3: 34,064,232	S535P	possibly damaging	Het
Gldc	A	T	19: 30,133,756	V540D	probably damaging	Het
Iqcf6	A	G	9: 106,627,508	T124A	probably benign	Het
Itih4	A	G	14: 30,887,817	I35V	possibly damaging	Het
Kmt2c	T	C	5: 25,273,666	*1525W	probably null	Het
Kmt2c	A	T	5: 25,354,771	V963E	probably damaging	Het
Lmnb2	T	C	10: 80,907,165	S202G	probably benign	Het
Med23	T	G	10: 24,903,798	S924R	probably benign	Het
Olfr1454	T	C	19: 13,064,149	V246A	probably damaging	Het
Pcif1	T	C	2: 164,886,611	F263L	possibly damaging	Het
Pon2	A	T	6: 5,272,331	L163H	probably damaging	Het
Scn1a	C	T	2: 66,302,485	V165M	possibly damaging	Het
Sema6d	C	A	2: 124,665,098	P961Q	probably damaging	Het
Snx27	A	G	3: 94,561,843	Y64H	probably damaging	Het
Srsf11	C	T	3: 158,012,035		probably benign	Het
Taok1	A	G	11: 77,571,684	V193A	probably damaging	Het
Vps13d	T	C	4: 145,016,901	T4137A	probably benign	Het
Zbtb26	T	C	2: 37,436,271	Y251C	probably damaging	Het
Zcchc11	A	G	4: 108,550,820		probably benign	Het

Other mutations in Ccdc177

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02433:Ccdc177	APN	12	80757598	missense	unknown
R0829:Ccdc177	UTSW	12	80759479	missense	probably damaging	0.96
R1739:Ccdc177	UTSW	12	80759239	missense	probably damaging	1.00
R1970:Ccdc177	UTSW	12	80758712	missense	unknown
R2337:Ccdc177	UTSW	12	80758691	missense	unknown
R5001:Ccdc177	UTSW	12	80757386	missense	unknown
R5164:Ccdc177	UTSW	12	80758562	missense	unknown
R5249:Ccdc177	UTSW	12	80758508	missense	unknown
R5461:Ccdc177	UTSW	12	80758042	missense	unknown
R6802:Ccdc177	UTSW	12	80759283	missense	probably damaging	1.00
R7051:Ccdc177	UTSW	12	80759153	missense	probably damaging	0.98
R7412:Ccdc177	UTSW	12	80759018	missense	possibly damaging	0.85
R7510:Ccdc177	UTSW	12	80757683	missense	unknown
R7511:Ccdc177	UTSW	12	80757683	missense	unknown
R7712:Ccdc177	UTSW	12	80757938	nonsense	probably null
R8036:Ccdc177	UTSW	12	80758123	missense	unknown
R8693:Ccdc177	UTSW	12	80757808	missense	unknown
R8708:Ccdc177	UTSW	12	80759117	missense	probably benign	0.08
R8862:Ccdc177	UTSW	12	80757434	missense	unknown
R8894:Ccdc177	UTSW	12	80759303	missense	probably damaging	1.00
R9423:Ccdc177	UTSW	12	80757388	missense	unknown
R9727:Ccdc177	UTSW	12	80759270	missense	probably benign	0.04
Z1177:Ccdc177	UTSW	12	80757736	missense	unknown

Posted On

2013-12-09