Incidental Mutation 'IGL01598:Tut4'
ID 91760
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tut4
Ensembl Gene ENSMUSG00000034610
Gene Name terminal uridylyl transferase 4
Synonyms 9230115F04Rik, Tent3a, 6030404K05Rik, Zcchc11
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01598
Quality Score
Status
Chromosome 4
Chromosomal Location 108316623-108416618 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 108408017 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000116253 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043368] [ENSMUST00000097925] [ENSMUST00000128042]
AlphaFold B2RX14
Predicted Effect probably benign
Transcript: ENSMUST00000043368
SMART Domains Protein: ENSMUSP00000044836
Gene: ENSMUSG00000034610

DomainStartEndE-ValueType
low complexity region 260 275 N/A INTRINSIC
SCOP:d1f5aa2 363 569 2e-23 SMART
Pfam:PAP_assoc 648 701 1.2e-13 PFAM
low complexity region 743 758 N/A INTRINSIC
low complexity region 815 828 N/A INTRINSIC
ZnF_C2HC 931 947 7.79e-3 SMART
Pfam:NTP_transf_2 995 1085 4.2e-10 PFAM
Pfam:PAP_assoc 1201 1254 4.7e-19 PFAM
ZnF_C2HC 1311 1327 3.83e-3 SMART
ZnF_C2HC 1359 1375 3.44e-4 SMART
low complexity region 1398 1412 N/A INTRINSIC
low complexity region 1418 1473 N/A INTRINSIC
low complexity region 1628 1639 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000097925
SMART Domains Protein: ENSMUSP00000095538
Gene: ENSMUSG00000034610

DomainStartEndE-ValueType
low complexity region 260 275 N/A INTRINSIC
SCOP:d1f5aa2 363 569 2e-23 SMART
Pfam:PAP_assoc 648 701 8e-14 PFAM
low complexity region 743 758 N/A INTRINSIC
low complexity region 815 828 N/A INTRINSIC
ZnF_C2HC 931 947 7.79e-3 SMART
Pfam:NTP_transf_2 994 1082 6.3e-11 PFAM
Pfam:PAP_assoc 1201 1254 5.2e-19 PFAM
ZnF_C2HC 1311 1327 3.83e-3 SMART
ZnF_C2HC 1364 1380 3.44e-4 SMART
low complexity region 1403 1417 N/A INTRINSIC
low complexity region 1423 1478 N/A INTRINSIC
low complexity region 1632 1643 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127602
Predicted Effect probably benign
Transcript: ENSMUST00000128042
SMART Domains Protein: ENSMUSP00000116253
Gene: ENSMUSG00000034610

DomainStartEndE-ValueType
low complexity region 89 100 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145590
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151349
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit partial postnatal lethality associated with postnatal growth retardation and reduced circulating insulin-like growth factor I levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410124H12Rik T A 16: 92,275,817 (GRCm39) noncoding transcript Het
Apc2 T A 10: 80,148,882 (GRCm39) L1283Q probably damaging Het
Apol6 G A 15: 76,934,916 (GRCm39) A62T probably damaging Het
AU018091 A T 7: 3,212,110 (GRCm39) I204N possibly damaging Het
B4galnt4 G T 7: 140,650,428 (GRCm39) R765L probably benign Het
Brca1 T C 11: 101,415,156 (GRCm39) T993A probably benign Het
Cadps C T 14: 12,522,202 (GRCm38) probably null Het
Ccdc177 A G 12: 80,805,519 (GRCm39) S252P unknown Het
Cdc73 A G 1: 143,575,017 (GRCm39) S59P probably damaging Het
Cep63 G T 9: 102,467,657 (GRCm39) Q570K possibly damaging Het
Ces1c A T 8: 93,845,041 (GRCm39) I120K probably benign Het
Cpeb1 T C 7: 81,011,549 (GRCm39) M131V probably benign Het
Dync1h1 G A 12: 110,624,562 (GRCm39) V3701I probably damaging Het
Fxr1 T C 3: 34,118,381 (GRCm39) S535P possibly damaging Het
Gldc A T 19: 30,111,156 (GRCm39) V540D probably damaging Het
Iqcf6 A G 9: 106,504,707 (GRCm39) T124A probably benign Het
Itih4 A G 14: 30,609,774 (GRCm39) I35V possibly damaging Het
Kmt2c T C 5: 25,478,664 (GRCm39) *1525W probably null Het
Kmt2c A T 5: 25,559,769 (GRCm39) V963E probably damaging Het
Lmnb2 T C 10: 80,742,999 (GRCm39) S202G probably benign Het
Med23 T G 10: 24,779,696 (GRCm39) S924R probably benign Het
Or5b102 T C 19: 13,041,513 (GRCm39) V246A probably damaging Het
Pcif1 T C 2: 164,728,531 (GRCm39) F263L possibly damaging Het
Pon2 A T 6: 5,272,331 (GRCm39) L163H probably damaging Het
Scn1a C T 2: 66,132,829 (GRCm39) V165M possibly damaging Het
Sema6d C A 2: 124,507,018 (GRCm39) P961Q probably damaging Het
Snx27 A G 3: 94,469,150 (GRCm39) Y64H probably damaging Het
Srsf11 C T 3: 157,717,672 (GRCm39) probably benign Het
Taok1 A G 11: 77,462,510 (GRCm39) V193A probably damaging Het
Vps13d T C 4: 144,743,471 (GRCm39) T4137A probably benign Het
Zbtb26 T C 2: 37,326,283 (GRCm39) Y251C probably damaging Het
Other mutations in Tut4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Tut4 APN 4 108,407,925 (GRCm39) missense probably damaging 1.00
IGL00684:Tut4 APN 4 108,336,663 (GRCm39) missense possibly damaging 0.80
IGL01599:Tut4 APN 4 108,370,596 (GRCm39) missense possibly damaging 0.85
IGL02088:Tut4 APN 4 108,369,415 (GRCm39) splice site probably benign
IGL02451:Tut4 APN 4 108,386,473 (GRCm39) nonsense probably null
IGL02667:Tut4 APN 4 108,415,905 (GRCm39) splice site probably benign
IGL03080:Tut4 APN 4 108,363,021 (GRCm39) missense probably damaging 1.00
IGL03374:Tut4 APN 4 108,415,974 (GRCm39) missense probably damaging 1.00
Flatter UTSW 4 108,399,908 (GRCm39) critical splice donor site probably null
Ingratiate UTSW 4 108,369,392 (GRCm39) missense probably damaging 1.00
oedipus UTSW 4 108,406,552 (GRCm39) missense probably damaging 1.00
Please UTSW 4 108,370,083 (GRCm39) nonsense probably null
H8786:Tut4 UTSW 4 108,408,012 (GRCm39) critical splice donor site probably null
IGL02799:Tut4 UTSW 4 108,370,725 (GRCm39) missense probably benign
R0013:Tut4 UTSW 4 108,388,152 (GRCm39) splice site probably benign
R0013:Tut4 UTSW 4 108,388,152 (GRCm39) splice site probably benign
R0051:Tut4 UTSW 4 108,384,201 (GRCm39) missense probably damaging 1.00
R0051:Tut4 UTSW 4 108,384,201 (GRCm39) missense probably damaging 1.00
R0410:Tut4 UTSW 4 108,343,752 (GRCm39) missense probably benign 0.27
R0698:Tut4 UTSW 4 108,412,730 (GRCm39) missense probably benign 0.22
R0745:Tut4 UTSW 4 108,360,152 (GRCm39) splice site probably benign
R1080:Tut4 UTSW 4 108,336,696 (GRCm39) missense possibly damaging 0.82
R1774:Tut4 UTSW 4 108,365,152 (GRCm39) missense probably damaging 1.00
R1809:Tut4 UTSW 4 108,406,552 (GRCm39) missense probably damaging 1.00
R1869:Tut4 UTSW 4 108,386,497 (GRCm39) missense probably damaging 1.00
R1874:Tut4 UTSW 4 108,407,922 (GRCm39) missense probably damaging 1.00
R1958:Tut4 UTSW 4 108,412,903 (GRCm39) missense probably damaging 1.00
R1976:Tut4 UTSW 4 108,336,720 (GRCm39) missense probably benign 0.01
R2034:Tut4 UTSW 4 108,369,392 (GRCm39) missense probably damaging 1.00
R2164:Tut4 UTSW 4 108,360,226 (GRCm39) missense possibly damaging 0.73
R2251:Tut4 UTSW 4 108,377,405 (GRCm39) missense probably damaging 1.00
R3001:Tut4 UTSW 4 108,370,125 (GRCm39) missense probably damaging 1.00
R3002:Tut4 UTSW 4 108,370,125 (GRCm39) missense probably damaging 1.00
R3003:Tut4 UTSW 4 108,370,125 (GRCm39) missense probably damaging 1.00
R4170:Tut4 UTSW 4 108,405,256 (GRCm39) missense probably damaging 1.00
R4667:Tut4 UTSW 4 108,352,356 (GRCm39) missense probably damaging 1.00
R4868:Tut4 UTSW 4 108,406,417 (GRCm39) splice site probably benign
R4989:Tut4 UTSW 4 108,384,042 (GRCm39) unclassified probably benign
R5014:Tut4 UTSW 4 108,384,043 (GRCm39) unclassified probably benign
R5118:Tut4 UTSW 4 108,377,489 (GRCm39) missense possibly damaging 0.92
R5431:Tut4 UTSW 4 108,348,609 (GRCm39) missense probably damaging 1.00
R5645:Tut4 UTSW 4 108,414,570 (GRCm39) missense probably damaging 1.00
R5661:Tut4 UTSW 4 108,370,384 (GRCm39) missense probably benign 0.05
R5877:Tut4 UTSW 4 108,370,120 (GRCm39) missense probably damaging 0.99
R6307:Tut4 UTSW 4 108,412,817 (GRCm39) missense probably damaging 1.00
R6326:Tut4 UTSW 4 108,336,177 (GRCm39) missense probably benign 0.02
R6407:Tut4 UTSW 4 108,415,979 (GRCm39) missense probably damaging 1.00
R6493:Tut4 UTSW 4 108,384,002 (GRCm39) missense probably damaging 1.00
R6587:Tut4 UTSW 4 108,336,646 (GRCm39) missense probably benign
R7215:Tut4 UTSW 4 108,384,205 (GRCm39) missense probably damaging 1.00
R7413:Tut4 UTSW 4 108,406,533 (GRCm39) missense possibly damaging 0.69
R7584:Tut4 UTSW 4 108,336,543 (GRCm39) missense probably benign 0.00
R7872:Tut4 UTSW 4 108,374,715 (GRCm39) missense probably damaging 1.00
R7970:Tut4 UTSW 4 108,343,651 (GRCm39) missense probably benign 0.00
R8214:Tut4 UTSW 4 108,369,347 (GRCm39) missense probably benign 0.00
R8297:Tut4 UTSW 4 108,336,905 (GRCm39) missense possibly damaging 0.86
R8504:Tut4 UTSW 4 108,388,139 (GRCm39) missense probably damaging 1.00
R8514:Tut4 UTSW 4 108,414,554 (GRCm39) missense possibly damaging 0.65
R8557:Tut4 UTSW 4 108,399,908 (GRCm39) critical splice donor site probably null
R8750:Tut4 UTSW 4 108,407,940 (GRCm39) missense probably damaging 1.00
R8805:Tut4 UTSW 4 108,406,575 (GRCm39) missense possibly damaging 0.83
R8903:Tut4 UTSW 4 108,336,408 (GRCm39) missense probably damaging 1.00
R9003:Tut4 UTSW 4 108,400,029 (GRCm39) missense probably damaging 0.98
R9218:Tut4 UTSW 4 108,370,083 (GRCm39) nonsense probably null
R9412:Tut4 UTSW 4 108,414,561 (GRCm39) missense
R9546:Tut4 UTSW 4 108,370,429 (GRCm39) missense probably benign 0.05
R9547:Tut4 UTSW 4 108,370,429 (GRCm39) missense probably benign 0.05
R9721:Tut4 UTSW 4 108,412,778 (GRCm39) missense probably benign 0.22
Posted On 2013-12-09