Incidental Mutation 'IGL01610:Acot10'
ID 91961
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Acot10
Ensembl Gene ENSMUSG00000047565
Gene Name acyl-CoA thioesterase 10
Synonyms p48, MT-ACT48, Acate3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # IGL01610
Quality Score
Status
Chromosome 15
Chromosomal Location 20665300-20666836 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20665781 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 320 (Y320C)
Ref Sequence ENSEMBL: ENSMUSP00000051333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052910]
AlphaFold Q32MW3
Predicted Effect probably damaging
Transcript: ENSMUST00000052910
AA Change: Y320C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000051333
Gene: ENSMUSG00000047565
AA Change: Y320C

DomainStartEndE-ValueType
SCOP:d1lo7a_ 108 222 1e-4 SMART
PDB:4IEN|D 277 400 3e-6 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226407
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227439
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228652
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018A14Rik T C 18: 46,332,633 (GRCm39) probably benign Het
4921524J17Rik T C 8: 86,138,871 (GRCm39) I73V probably benign Het
4930562C15Rik T A 16: 4,669,429 (GRCm39) probably benign Het
Abca15 T A 7: 119,939,867 (GRCm39) V323D probably damaging Het
Acp6 T A 3: 97,083,036 (GRCm39) V349D possibly damaging Het
Adcy9 G T 16: 4,235,978 (GRCm39) Q478K probably damaging Het
Akap13 A G 7: 75,369,928 (GRCm39) I1843V possibly damaging Het
Akap13 A T 7: 75,397,353 (GRCm39) I2528F probably damaging Het
Akap9 G A 5: 4,082,839 (GRCm39) A1988T possibly damaging Het
Alox5 C T 6: 116,390,508 (GRCm39) V490M probably damaging Het
Aspm C T 1: 139,417,408 (GRCm39) R1537* probably null Het
Bmf G A 2: 118,379,639 (GRCm39) P46S probably benign Het
Brf1 T A 12: 112,951,703 (GRCm39) H92L probably benign Het
Chchd1 A G 14: 20,753,245 (GRCm39) N35S probably benign Het
Cntnap3 C T 13: 64,905,115 (GRCm39) G889S probably damaging Het
Col6a4 T C 9: 105,924,906 (GRCm39) probably benign Het
Crispld1 A G 1: 17,816,949 (GRCm39) probably null Het
Ddx27 T C 2: 166,863,964 (GRCm39) probably benign Het
Dennd1b A G 1: 139,097,504 (GRCm39) probably benign Het
Dennd4a T C 9: 64,814,166 (GRCm39) V1461A probably damaging Het
Drc7 C T 8: 95,804,430 (GRCm39) R843W probably damaging Het
Dync2li1 A G 17: 84,935,742 (GRCm39) E13G probably damaging Het
Egf A G 3: 129,499,909 (GRCm39) probably benign Het
Hpse2 T C 19: 43,373,228 (GRCm39) S134G probably benign Het
Hydin A G 8: 111,284,345 (GRCm39) T3206A probably benign Het
Ier5l T A 2: 30,363,966 (GRCm39) S20C probably damaging Het
Il1r1 A G 1: 40,341,560 (GRCm39) E324G probably benign Het
Kdm4b C T 17: 56,660,522 (GRCm39) probably benign Het
Lztfl1 T A 9: 123,529,156 (GRCm39) E298D probably benign Het
Myo1b A T 1: 51,815,405 (GRCm39) M647K probably damaging Het
Or13a25 C T 7: 140,247,584 (GRCm39) A128V probably damaging Het
Or52z14 A T 7: 103,253,274 (GRCm39) T138S probably benign Het
Or5j1 G T 2: 86,878,632 (GRCm39) probably benign Het
Parvb A T 15: 84,187,666 (GRCm39) K258M probably damaging Het
Pcdhb11 T G 18: 37,556,412 (GRCm39) S581A probably benign Het
Pcnx2 C A 8: 126,566,372 (GRCm39) A1024S possibly damaging Het
Pde4a T C 9: 21,122,646 (GRCm39) probably benign Het
Pgr A T 9: 8,903,692 (GRCm39) H571L possibly damaging Het
Phf20 G T 2: 156,144,809 (GRCm39) E806* probably null Het
Pilra T A 5: 137,833,803 (GRCm39) I85F probably damaging Het
Pla2g2f C T 4: 138,480,622 (GRCm39) V125M probably damaging Het
Rb1cc1 A G 1: 6,318,705 (GRCm39) N708S probably benign Het
Resf1 C T 6: 149,230,449 (GRCm39) T1165M probably benign Het
Rnase4 A T 14: 51,342,378 (GRCm39) Y34F probably damaging Het
Ropn1 A T 16: 34,487,141 (GRCm39) I26F probably damaging Het
Rpl9-ps6 T A 19: 32,443,699 (GRCm39) T85S probably benign Het
Scaf8 C T 17: 3,246,124 (GRCm39) P738S probably damaging Het
Sec31a A T 5: 100,550,217 (GRCm39) probably benign Het
Sel1l C T 12: 91,784,064 (GRCm39) V459I probably damaging Het
Senp7 A T 16: 55,996,186 (GRCm39) D755V possibly damaging Het
Serpinb9d A T 13: 33,381,985 (GRCm39) K151N probably benign Het
Slc8a3 A G 12: 81,362,576 (GRCm39) F81S probably damaging Het
Spire2 T A 8: 124,083,502 (GRCm39) L162Q probably damaging Het
Syt17 A G 7: 118,033,216 (GRCm39) I264T possibly damaging Het
Tbl3 A T 17: 24,923,018 (GRCm39) V379D probably damaging Het
Tenm3 A T 8: 48,707,512 (GRCm39) L1762Q probably damaging Het
Trerf1 A T 17: 47,630,501 (GRCm39) noncoding transcript Het
Ttc13 T C 8: 125,403,083 (GRCm39) D552G probably damaging Het
Tuba3a G T 6: 125,255,529 (GRCm39) T382K possibly damaging Het
Vmn1r210 A T 13: 23,011,977 (GRCm39) V103E probably damaging Het
Vmn1r80 A G 7: 11,927,307 (GRCm39) H139R possibly damaging Het
Xpo7 A T 14: 70,940,670 (GRCm39) F141Y probably damaging Het
Zfp143 T A 7: 109,673,333 (GRCm39) Y143* probably null Het
Zfp207 T A 11: 80,276,796 (GRCm39) C26S probably damaging Het
Other mutations in Acot10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01306:Acot10 APN 15 20,666,051 (GRCm39) missense probably benign 0.11
IGL02457:Acot10 APN 15 20,666,229 (GRCm39) missense possibly damaging 0.88
IGL02587:Acot10 APN 15 20,665,883 (GRCm39) missense possibly damaging 0.93
IGL02951:Acot10 APN 15 20,665,868 (GRCm39) missense probably benign 0.36
ANU23:Acot10 UTSW 15 20,666,051 (GRCm39) missense probably benign 0.11
PIT4151001:Acot10 UTSW 15 20,666,684 (GRCm39) missense probably damaging 0.98
R0026:Acot10 UTSW 15 20,666,322 (GRCm39) missense probably benign 0.10
R0026:Acot10 UTSW 15 20,666,322 (GRCm39) missense probably benign 0.10
R0462:Acot10 UTSW 15 20,666,712 (GRCm39) missense possibly damaging 0.85
R1312:Acot10 UTSW 15 20,666,585 (GRCm39) missense probably benign 0.00
R1495:Acot10 UTSW 15 20,665,593 (GRCm39) missense probably damaging 0.99
R2128:Acot10 UTSW 15 20,666,712 (GRCm39) missense probably benign 0.00
R3779:Acot10 UTSW 15 20,665,628 (GRCm39) missense probably damaging 0.98
R4110:Acot10 UTSW 15 20,666,612 (GRCm39) missense probably damaging 1.00
R4111:Acot10 UTSW 15 20,666,612 (GRCm39) missense probably damaging 1.00
R4464:Acot10 UTSW 15 20,665,830 (GRCm39) nonsense probably null
R4668:Acot10 UTSW 15 20,666,028 (GRCm39) missense probably benign
R4933:Acot10 UTSW 15 20,666,416 (GRCm39) missense possibly damaging 0.88
R5255:Acot10 UTSW 15 20,666,018 (GRCm39) missense probably benign 0.01
R5885:Acot10 UTSW 15 20,666,190 (GRCm39) missense probably benign 0.01
R6190:Acot10 UTSW 15 20,665,871 (GRCm39) missense possibly damaging 0.80
R6301:Acot10 UTSW 15 20,666,348 (GRCm39) missense probably benign 0.05
R6805:Acot10 UTSW 15 20,665,452 (GRCm39) missense probably benign 0.42
R7334:Acot10 UTSW 15 20,665,629 (GRCm39) missense possibly damaging 0.86
R7601:Acot10 UTSW 15 20,665,715 (GRCm39) missense probably damaging 1.00
R8400:Acot10 UTSW 15 20,666,258 (GRCm39) missense possibly damaging 0.56
R9195:Acot10 UTSW 15 20,665,517 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-09