Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01610:Or13a25'

91964

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or13a25

Ensembl Gene

ENSMUSG00000059136

Gene Name

olfactory receptor family 13 subfamily A member 25

Synonyms

GA_x6K02T2PBJ9-42813436-42814368, Olfr539, MOR253-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01610

Quality Score

Status

Chromosome

Chromosomal Location

140247202-140248161 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 140247584 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 128 (A128V)

Ref Sequence

ENSEMBL: ENSMUSP00000077990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078967] [ENSMUST00000210973] [ENSMUST00000218865]

AlphaFold

Q8VGL9

Predicted Effect

probably damaging
Transcript: ENSMUST00000078967
AA Change: A128V

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000077990
Gene: ENSMUSG00000059136
AA Change: A128V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	40	316	6.5e-50	PFAM
Pfam:7tm_1	50	299	4.9e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210499

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210973
AA Change: A121V

Predicted Effect

probably damaging
Transcript: ENSMUST00000218865
AA Change: A121V

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219579

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219853

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018A14Rik	T	C	18: 46,332,633 (GRCm39)		probably benign	Het
4921524J17Rik	T	C	8: 86,138,871 (GRCm39)	I73V	probably benign	Het
4930562C15Rik	T	A	16: 4,669,429 (GRCm39)		probably benign	Het
Abca15	T	A	7: 119,939,867 (GRCm39)	V323D	probably damaging	Het
Acot10	T	C	15: 20,665,781 (GRCm39)	Y320C	probably damaging	Het
Acp6	T	A	3: 97,083,036 (GRCm39)	V349D	possibly damaging	Het
Adcy9	G	T	16: 4,235,978 (GRCm39)	Q478K	probably damaging	Het
Akap13	A	G	7: 75,369,928 (GRCm39)	I1843V	possibly damaging	Het
Akap13	A	T	7: 75,397,353 (GRCm39)	I2528F	probably damaging	Het
Akap9	G	A	5: 4,082,839 (GRCm39)	A1988T	possibly damaging	Het
Alox5	C	T	6: 116,390,508 (GRCm39)	V490M	probably damaging	Het
Aspm	C	T	1: 139,417,408 (GRCm39)	R1537*	probably null	Het
Bmf	G	A	2: 118,379,639 (GRCm39)	P46S	probably benign	Het
Brf1	T	A	12: 112,951,703 (GRCm39)	H92L	probably benign	Het
Chchd1	A	G	14: 20,753,245 (GRCm39)	N35S	probably benign	Het
Cntnap3	C	T	13: 64,905,115 (GRCm39)	G889S	probably damaging	Het
Col6a4	T	C	9: 105,924,906 (GRCm39)		probably benign	Het
Crispld1	A	G	1: 17,816,949 (GRCm39)		probably null	Het
Ddx27	T	C	2: 166,863,964 (GRCm39)		probably benign	Het
Dennd1b	A	G	1: 139,097,504 (GRCm39)		probably benign	Het
Dennd4a	T	C	9: 64,814,166 (GRCm39)	V1461A	probably damaging	Het
Drc7	C	T	8: 95,804,430 (GRCm39)	R843W	probably damaging	Het
Dync2li1	A	G	17: 84,935,742 (GRCm39)	E13G	probably damaging	Het
Egf	A	G	3: 129,499,909 (GRCm39)		probably benign	Het
Hpse2	T	C	19: 43,373,228 (GRCm39)	S134G	probably benign	Het
Hydin	A	G	8: 111,284,345 (GRCm39)	T3206A	probably benign	Het
Ier5l	T	A	2: 30,363,966 (GRCm39)	S20C	probably damaging	Het
Il1r1	A	G	1: 40,341,560 (GRCm39)	E324G	probably benign	Het
Kdm4b	C	T	17: 56,660,522 (GRCm39)		probably benign	Het
Lztfl1	T	A	9: 123,529,156 (GRCm39)	E298D	probably benign	Het
Myo1b	A	T	1: 51,815,405 (GRCm39)	M647K	probably damaging	Het
Or52z14	A	T	7: 103,253,274 (GRCm39)	T138S	probably benign	Het
Or5j1	G	T	2: 86,878,632 (GRCm39)		probably benign	Het
Parvb	A	T	15: 84,187,666 (GRCm39)	K258M	probably damaging	Het
Pcdhb11	T	G	18: 37,556,412 (GRCm39)	S581A	probably benign	Het
Pcnx2	C	A	8: 126,566,372 (GRCm39)	A1024S	possibly damaging	Het
Pde4a	T	C	9: 21,122,646 (GRCm39)		probably benign	Het
Pgr	A	T	9: 8,903,692 (GRCm39)	H571L	possibly damaging	Het
Phf20	G	T	2: 156,144,809 (GRCm39)	E806*	probably null	Het
Pilra	T	A	5: 137,833,803 (GRCm39)	I85F	probably damaging	Het
Pla2g2f	C	T	4: 138,480,622 (GRCm39)	V125M	probably damaging	Het
Rb1cc1	A	G	1: 6,318,705 (GRCm39)	N708S	probably benign	Het
Resf1	C	T	6: 149,230,449 (GRCm39)	T1165M	probably benign	Het
Rnase4	A	T	14: 51,342,378 (GRCm39)	Y34F	probably damaging	Het
Ropn1	A	T	16: 34,487,141 (GRCm39)	I26F	probably damaging	Het
Rpl9-ps6	T	A	19: 32,443,699 (GRCm39)	T85S	probably benign	Het
Scaf8	C	T	17: 3,246,124 (GRCm39)	P738S	probably damaging	Het
Sec31a	A	T	5: 100,550,217 (GRCm39)		probably benign	Het
Sel1l	C	T	12: 91,784,064 (GRCm39)	V459I	probably damaging	Het
Senp7	A	T	16: 55,996,186 (GRCm39)	D755V	possibly damaging	Het
Serpinb9d	A	T	13: 33,381,985 (GRCm39)	K151N	probably benign	Het
Slc8a3	A	G	12: 81,362,576 (GRCm39)	F81S	probably damaging	Het
Spire2	T	A	8: 124,083,502 (GRCm39)	L162Q	probably damaging	Het
Syt17	A	G	7: 118,033,216 (GRCm39)	I264T	possibly damaging	Het
Tbl3	A	T	17: 24,923,018 (GRCm39)	V379D	probably damaging	Het
Tenm3	A	T	8: 48,707,512 (GRCm39)	L1762Q	probably damaging	Het
Trerf1	A	T	17: 47,630,501 (GRCm39)		noncoding transcript	Het
Ttc13	T	C	8: 125,403,083 (GRCm39)	D552G	probably damaging	Het
Tuba3a	G	T	6: 125,255,529 (GRCm39)	T382K	possibly damaging	Het
Vmn1r210	A	T	13: 23,011,977 (GRCm39)	V103E	probably damaging	Het
Vmn1r80	A	G	7: 11,927,307 (GRCm39)	H139R	possibly damaging	Het
Xpo7	A	T	14: 70,940,670 (GRCm39)	F141Y	probably damaging	Het
Zfp143	T	A	7: 109,673,333 (GRCm39)	Y143*	probably null	Het
Zfp207	T	A	11: 80,276,796 (GRCm39)	C26S	probably damaging	Het

Other mutations in Or13a25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Or13a25	APN	7	140,247,854 (GRCm39)	missense	probably benign	0.01
IGL02959:Or13a25	APN	7	140,247,463 (GRCm39)	missense	probably damaging	1.00
IGL03406:Or13a25	APN	7	140,247,424 (GRCm39)	missense	probably damaging	1.00
R0671:Or13a25	UTSW	7	140,247,590 (GRCm39)	missense	probably damaging	1.00
R1771:Or13a25	UTSW	7	140,248,048 (GRCm39)	missense	probably benign
R1934:Or13a25	UTSW	7	140,247,951 (GRCm39)	nonsense	probably null
R1985:Or13a25	UTSW	7	140,247,734 (GRCm39)	missense	probably damaging	1.00
R2962:Or13a25	UTSW	7	140,247,862 (GRCm39)	missense	probably benign
R4239:Or13a25	UTSW	7	140,247,496 (GRCm39)	missense	probably benign	0.07
R4240:Or13a25	UTSW	7	140,247,496 (GRCm39)	missense	probably benign	0.07
R4360:Or13a25	UTSW	7	140,247,730 (GRCm39)	missense	probably damaging	0.98
R4841:Or13a25	UTSW	7	140,247,502 (GRCm39)	missense	probably damaging	1.00
R4842:Or13a25	UTSW	7	140,247,502 (GRCm39)	missense	probably damaging	1.00
R4851:Or13a25	UTSW	7	140,247,226 (GRCm39)	missense	probably benign
R5325:Or13a25	UTSW	7	140,247,705 (GRCm39)	missense	probably benign	0.33
R5766:Or13a25	UTSW	7	140,247,266 (GRCm39)	missense	probably benign	0.02
R6363:Or13a25	UTSW	7	140,247,995 (GRCm39)	missense	possibly damaging	0.93
R6836:Or13a25	UTSW	7	140,248,093 (GRCm39)	missense	possibly damaging	0.86
R7777:Or13a25	UTSW	7	140,247,854 (GRCm39)	missense	probably benign	0.01
R7920:Or13a25	UTSW	7	140,247,814 (GRCm39)	missense	possibly damaging	0.92
R8134:Or13a25	UTSW	7	140,247,680 (GRCm39)	missense	possibly damaging	0.90
R8712:Or13a25	UTSW	7	140,248,052 (GRCm39)	missense	possibly damaging	0.89
R9095:Or13a25	UTSW	7	140,247,813 (GRCm39)	missense	probably damaging	1.00
R9158:Or13a25	UTSW	7	140,247,547 (GRCm39)	missense	possibly damaging	0.76
R9603:Or13a25	UTSW	7	140,247,794 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09