Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01599:Wrn'

92067

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wrn

Ensembl Gene

ENSMUSG00000031583

Gene Name

Werner syndrome RecQ like helicase

Synonyms

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.381) question?

Stock #

IGL01599

Quality Score

Status

Chromosome

Chromosomal Location

33234384-33385527 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 33241011 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 1098 (P1098S)

Ref Sequence

ENSEMBL: ENSMUSP00000147379 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033990] [ENSMUST00000033991] [ENSMUST00000211498]

AlphaFold

O09053

Predicted Effect

probably benign
Transcript: ENSMUST00000033990
AA Change: P1341S

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000033990
Gene: ENSMUSG00000031583
AA Change: P1341S

Domain	Start	End	E-Value	Type
35EXOc	47	226	1e-47	SMART
low complexity region	484	489	N/A	INTRINSIC
DEXDc	509	704	2.3e-28	SMART
HELICc	743	824	3.7e-27	SMART
RQC	923	1028	3.1e-28	SMART
HRDC	1115	1194	1.5e-26	SMART
low complexity region	1205	1216	N/A	INTRINSIC
Pfam:HTH_40	1222	1318	2.7e-9	PFAM
low complexity region	1342	1356	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000033991
AA Change: P1341S

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000033991
Gene: ENSMUSG00000031583
AA Change: P1341S

Domain	Start	End	E-Value	Type
35EXOc	47	226	1.1e-47	SMART
low complexity region	484	489	N/A	INTRINSIC
DEXDc	509	704	2.4e-28	SMART
HELICc	743	824	3.7e-27	SMART
Pfam:RecQ_Zn_bind	835	905	2.2e-8	PFAM
RQC	923	1028	3.2e-28	SMART
HRDC	1115	1194	1.5e-26	SMART
low complexity region	1205	1216	N/A	INTRINSIC
Pfam:HTH_40	1223	1317	4.3e-10	PFAM
low complexity region	1342	1356	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000211498
AA Change: P1098S

PolyPhen 2 Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr3	T	C	1: 90,214,134 (GRCm38)	V105A	probably benign	Het
Acr	T	C	15: 89,568,414 (GRCm38)	V18A	probably benign	Het
Adgra2	G	A	8: 27,118,733 (GRCm38)	A540T	possibly damaging	Het
Aldh16a1	A	G	7: 45,142,093 (GRCm38)	F753L	probably damaging	Het
Ankfy1	T	A	11: 72,738,365 (GRCm38)	Y338N	probably benign	Het
Aox3	C	T	1: 58,169,794 (GRCm38)	R829C	probably damaging	Het
Arhgef11	T	C	3: 87,737,046 (GRCm38)	S1535P	probably benign	Het
C4b	A	G	17: 34,743,019 (GRCm38)		probably benign	Het
Ccdc157	A	G	11: 4,148,781 (GRCm38)	C242R	probably damaging	Het
Cep135	T	A	5: 76,593,347 (GRCm38)	M90K	possibly damaging	Het
Cfap36	A	T	11: 29,244,057 (GRCm38)		probably null	Het
Chl1	A	G	6: 103,708,484 (GRCm38)	T829A	probably benign	Het
Copb2	T	C	9: 98,581,150 (GRCm38)	S473P	probably damaging	Het
Cpb1	C	T	3: 20,251,954 (GRCm38)		probably null	Het
Cpsf1	A	G	15: 76,596,541 (GRCm38)	L1295P	probably damaging	Het
Dmp1	C	T	5: 104,212,462 (GRCm38)	Q335*	probably null	Het
Dyrk1a	T	A	16: 94,691,884 (GRCm38)	S621T	possibly damaging	Het
Exoc5	T	A	14: 49,034,964 (GRCm38)	Q331L	probably benign	Het
Fmnl1	G	A	11: 103,186,656 (GRCm38)	V287M	probably damaging	Het
Fras1	T	C	5: 96,709,891 (GRCm38)	S2015P	possibly damaging	Het
Gm7052	T	C	17: 22,040,004 (GRCm38)		probably benign	Het
Gprc5c	A	G	11: 114,864,252 (GRCm38)	I252V	probably benign	Het
Ints3	C	T	3: 90,394,322 (GRCm38)		probably null	Het
L1td1	A	G	4: 98,737,344 (GRCm38)	D592G	probably damaging	Het
Lamb3	A	G	1: 193,343,412 (GRCm38)	M1137V	probably benign	Het
Leng8	C	A	7: 4,145,482 (GRCm38)	A751E	probably benign	Het
Lfng	T	C	5: 140,612,535 (GRCm38)	V204A	probably damaging	Het
Lsm14b	A	G	2: 180,032,603 (GRCm38)	D233G	probably damaging	Het
Map4	C	T	9: 110,034,768 (GRCm38)	P354S	probably benign	Het
Mapt	G	A	11: 104,294,915 (GRCm38)	V53M	probably damaging	Het
Mier1	T	G	4: 103,155,541 (GRCm38)	S377A	possibly damaging	Het
Neurog1	T	C	13: 56,251,847 (GRCm38)	D29G	probably damaging	Het
Npr3	G	A	15: 11,895,789 (GRCm38)	A257V	probably damaging	Het
Nup188	T	C	2: 30,327,525 (GRCm38)	V824A	possibly damaging	Het
Olfm4	T	C	14: 80,021,310 (GRCm38)	S333P	probably damaging	Het
Or7g30	T	G	9: 19,441,815 (GRCm38)	F301V	probably benign	Het
Or9a4	A	C	6: 40,572,252 (GRCm38)	I289L	probably damaging	Het
Pbxip1	C	A	3: 89,443,590 (GRCm38)		probably benign	Het
Pde9a	G	T	17: 31,414,150 (GRCm38)	C38F	probably damaging	Het
Plb1	A	T	5: 32,342,544 (GRCm38)		probably benign	Het
Plcz1	T	C	6: 140,002,256 (GRCm38)		probably benign	Het
Plxnb1	T	C	9: 109,110,604 (GRCm38)	V1447A	probably damaging	Het
Pnldc1	A	T	17: 12,906,528 (GRCm38)	M73K	probably benign	Het
Psg20	C	T	7: 18,681,038 (GRCm38)	V311M	possibly damaging	Het
Psmd2	G	T	16: 20,659,405 (GRCm38)		probably null	Het
Rabgap1	T	C	2: 37,556,269 (GRCm38)	V859A	probably damaging	Het
Rad51b	T	A	12: 79,327,228 (GRCm38)	S194T	probably benign	Het
Rb1cc1	C	T	1: 6,248,771 (GRCm38)	Q788*	probably null	Het
Ror2	C	T	13: 53,111,617 (GRCm38)	G468R	probably damaging	Het
Slamf7	A	G	1: 171,641,186 (GRCm38)	I46T	possibly damaging	Het
Stab2	A	G	10: 86,922,895 (GRCm38)	S1060P	probably damaging	Het
Syndig1	T	A	2: 150,003,283 (GRCm38)	V242E	probably damaging	Het
Tgfbr3	G	A	5: 107,118,451 (GRCm38)	T801M	probably damaging	Het
Tmem132c	T	C	5: 127,359,552 (GRCm38)		probably benign	Het
Trav21-dv12	T	C	14: 53,876,731 (GRCm38)	Y103H	probably damaging	Het
Tut4	T	C	4: 108,513,399 (GRCm38)	S871P	possibly damaging	Het
Ubr3	T	C	2: 69,938,178 (GRCm38)	V443A	probably damaging	Het
Uhrf2	G	T	19: 30,092,120 (GRCm38)	C749F	probably damaging	Het
Ulk2	G	T	11: 61,791,436 (GRCm38)	S751*	probably null	Het
Xrcc5	T	C	1: 72,346,349 (GRCm38)	V533A	possibly damaging	Het
Zc3h13	T	C	14: 75,309,723 (GRCm38)	S223P	probably damaging	Het

Other mutations in Wrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Wrn	APN	8	33,322,377 (GRCm38)	splice site	probably benign
IGL00661:Wrn	APN	8	33,319,145 (GRCm38)	splice site	probably benign
IGL01472:Wrn	APN	8	33,329,172 (GRCm38)	missense	possibly damaging	0.93
IGL01544:Wrn	APN	8	33,324,526 (GRCm38)	missense	probably benign	0.00
IGL01688:Wrn	APN	8	33,310,702 (GRCm38)	splice site	probably benign
IGL01916:Wrn	APN	8	33,257,224 (GRCm38)	missense	possibly damaging	0.78
IGL01925:Wrn	APN	8	33,319,180 (GRCm38)	missense	probably benign	0.42
IGL02068:Wrn	APN	8	33,310,749 (GRCm38)	missense	probably benign	0.38
IGL02084:Wrn	APN	8	33,285,179 (GRCm38)	missense	probably benign
IGL02167:Wrn	APN	8	33,317,555 (GRCm38)	missense	probably damaging	1.00
IGL02230:Wrn	APN	8	33,317,563 (GRCm38)	missense	probably damaging	1.00
IGL02717:Wrn	APN	8	33,343,573 (GRCm38)	missense	probably damaging	1.00
IGL02982:Wrn	APN	8	33,343,066 (GRCm38)	missense	probably damaging	1.00
IGL03030:Wrn	APN	8	33,248,961 (GRCm38)	missense	possibly damaging	0.94
IGL03088:Wrn	APN	8	33,268,823 (GRCm38)	splice site	probably benign
IGL03179:Wrn	APN	8	33,310,706 (GRCm38)	splice site	probably null
IGL03306:Wrn	APN	8	33,336,121 (GRCm38)	missense	probably damaging	1.00
R0004:Wrn	UTSW	8	33,317,560 (GRCm38)	missense	probably damaging	1.00
R0190:Wrn	UTSW	8	33,240,983 (GRCm38)	missense	probably benign	0.02
R0441:Wrn	UTSW	8	33,268,750 (GRCm38)	missense	probably benign	0.24
R0463:Wrn	UTSW	8	33,280,815 (GRCm38)	missense	possibly damaging	0.84
R0538:Wrn	UTSW	8	33,336,091 (GRCm38)	missense	probably damaging	0.99
R0682:Wrn	UTSW	8	33,267,820 (GRCm38)	missense	probably benign	0.00
R0729:Wrn	UTSW	8	33,248,918 (GRCm38)	splice site	probably null
R0744:Wrn	UTSW	8	33,295,006 (GRCm38)	missense	possibly damaging	0.91
R0836:Wrn	UTSW	8	33,295,006 (GRCm38)	missense	possibly damaging	0.91
R1168:Wrn	UTSW	8	33,316,408 (GRCm38)	missense	probably damaging	1.00
R1301:Wrn	UTSW	8	33,292,686 (GRCm38)	missense	probably damaging	1.00
R1352:Wrn	UTSW	8	33,294,916 (GRCm38)	missense	probably benign	0.25
R1396:Wrn	UTSW	8	33,268,819 (GRCm38)	missense	probably damaging	1.00
R1432:Wrn	UTSW	8	33,319,141 (GRCm38)	splice site	probably benign
R1523:Wrn	UTSW	8	33,292,716 (GRCm38)	missense	probably benign	0.23
R1625:Wrn	UTSW	8	33,329,130 (GRCm38)	missense	probably benign	0.01
R1664:Wrn	UTSW	8	33,280,766 (GRCm38)	splice site	probably null
R1773:Wrn	UTSW	8	33,343,561 (GRCm38)	missense	probably damaging	1.00
R1864:Wrn	UTSW	8	33,288,864 (GRCm38)	missense	probably damaging	0.99
R1868:Wrn	UTSW	8	33,257,221 (GRCm38)	missense	probably benign	0.03
R2011:Wrn	UTSW	8	33,236,404 (GRCm38)	missense	probably benign	0.02
R2075:Wrn	UTSW	8	33,322,329 (GRCm38)	missense	probably benign	0.00
R2091:Wrn	UTSW	8	33,267,825 (GRCm38)	missense	probably benign
R2213:Wrn	UTSW	8	33,257,015 (GRCm38)	missense	probably benign	0.05
R2255:Wrn	UTSW	8	33,329,202 (GRCm38)	missense	probably benign	0.13
R2276:Wrn	UTSW	8	33,324,556 (GRCm38)	missense	probably benign	0.02
R3177:Wrn	UTSW	8	33,317,554 (GRCm38)	missense	probably damaging	1.00
R3277:Wrn	UTSW	8	33,317,554 (GRCm38)	missense	probably damaging	1.00
R3779:Wrn	UTSW	8	33,241,020 (GRCm38)	missense	probably damaging	1.00
R3827:Wrn	UTSW	8	33,324,520 (GRCm38)	missense	probably benign	0.00
R4111:Wrn	UTSW	8	33,352,155 (GRCm38)	missense	probably benign	0.02
R4392:Wrn	UTSW	8	33,251,832 (GRCm38)	missense	probably damaging	0.99
R4458:Wrn	UTSW	8	33,294,998 (GRCm38)	missense	probably damaging	0.99
R4650:Wrn	UTSW	8	33,255,509 (GRCm38)	missense	probably benign	0.05
R4656:Wrn	UTSW	8	33,335,991 (GRCm38)	splice site	probably null
R4657:Wrn	UTSW	8	33,335,991 (GRCm38)	splice site	probably null
R4667:Wrn	UTSW	8	33,324,338 (GRCm38)	missense	probably benign	0.00
R4735:Wrn	UTSW	8	33,285,222 (GRCm38)	missense	probably damaging	1.00
R4933:Wrn	UTSW	8	33,322,343 (GRCm38)	missense	probably benign	0.01
R5104:Wrn	UTSW	8	33,267,867 (GRCm38)	splice site	probably null
R5166:Wrn	UTSW	8	33,352,072 (GRCm38)	critical splice donor site	probably null
R5279:Wrn	UTSW	8	33,241,101 (GRCm38)	missense	probably damaging	1.00
R5400:Wrn	UTSW	8	33,294,917 (GRCm38)	missense	probably benign	0.02
R5575:Wrn	UTSW	8	33,336,130 (GRCm38)	missense	probably benign	0.02
R5695:Wrn	UTSW	8	33,324,318 (GRCm38)	missense	probably benign	0.26
R5729:Wrn	UTSW	8	33,268,778 (GRCm38)	missense	probably benign	0.02
R6044:Wrn	UTSW	8	33,236,429 (GRCm38)	missense	probably damaging	1.00
R6139:Wrn	UTSW	8	33,353,332 (GRCm38)	missense	probably damaging	1.00
R6158:Wrn	UTSW	8	33,319,172 (GRCm38)	missense	probably damaging	1.00
R6192:Wrn	UTSW	8	33,284,654 (GRCm38)	missense	probably benign	0.12
R6243:Wrn	UTSW	8	33,284,654 (GRCm38)	missense	possibly damaging	0.94
R6354:Wrn	UTSW	8	33,343,638 (GRCm38)	missense	possibly damaging	0.93
R6429:Wrn	UTSW	8	33,342,996 (GRCm38)	missense	probably damaging	1.00
R6490:Wrn	UTSW	8	33,319,220 (GRCm38)	missense	probably benign	0.01
R6529:Wrn	UTSW	8	33,335,976 (GRCm38)	splice site	probably null
R6535:Wrn	UTSW	8	33,336,103 (GRCm38)	missense	probably damaging	0.99
R7001:Wrn	UTSW	8	33,352,129 (GRCm38)	missense	probably benign	0.04
R7114:Wrn	UTSW	8	33,285,121 (GRCm38)	frame shift	probably null
R7198:Wrn	UTSW	8	33,324,318 (GRCm38)	missense	probably benign	0.00
R7200:Wrn	UTSW	8	33,322,348 (GRCm38)	missense	probably benign	0.00
R7227:Wrn	UTSW	8	33,248,946 (GRCm38)	missense	probably damaging	1.00
R7299:Wrn	UTSW	8	33,292,718 (GRCm38)	missense	probably damaging	1.00
R7374:Wrn	UTSW	8	33,268,911 (GRCm38)	missense	probably damaging	1.00
R7402:Wrn	UTSW	8	33,248,966 (GRCm38)	missense	probably benign	0.00
R7404:Wrn	UTSW	8	33,248,966 (GRCm38)	missense	probably benign	0.00
R7405:Wrn	UTSW	8	33,248,966 (GRCm38)	missense	probably benign	0.00
R7464:Wrn	UTSW	8	33,335,996 (GRCm38)	critical splice donor site	probably null
R7474:Wrn	UTSW	8	33,329,181 (GRCm38)	missense	probably damaging	0.96
R7609:Wrn	UTSW	8	33,310,713 (GRCm38)	missense	possibly damaging	0.50
R7729:Wrn	UTSW	8	33,324,426 (GRCm38)	missense	probably benign	0.21
R7830:Wrn	UTSW	8	33,269,054 (GRCm38)	missense	probably damaging	0.97
R7998:Wrn	UTSW	8	33,292,643 (GRCm38)	missense	probably benign	0.10
R8239:Wrn	UTSW	8	33,329,185 (GRCm38)	missense	probably damaging	1.00
R8262:Wrn	UTSW	8	33,324,246 (GRCm38)	missense	probably benign	0.07
R8410:Wrn	UTSW	8	33,269,020 (GRCm38)	missense	probably damaging	1.00
R8480:Wrn	UTSW	8	33,288,768 (GRCm38)	missense	probably benign	0.10
R8530:Wrn	UTSW	8	33,280,824 (GRCm38)	missense	possibly damaging	0.83
R8540:Wrn	UTSW	8	33,352,126 (GRCm38)	missense	probably damaging	0.96
R8708:Wrn	UTSW	8	33,292,643 (GRCm38)	missense	probably damaging	0.96
R8783:Wrn	UTSW	8	33,336,013 (GRCm38)	missense	probably null	1.00
R8870:Wrn	UTSW	8	33,329,192 (GRCm38)	missense	probably benign	0.01
R8876:Wrn	UTSW	8	33,324,394 (GRCm38)	missense	probably benign	0.00
R9050:Wrn	UTSW	8	33,342,993 (GRCm38)	missense	probably damaging	1.00
R9329:Wrn	UTSW	8	33,240,978 (GRCm38)	missense	probably benign
R9595:Wrn	UTSW	8	33,268,933 (GRCm38)	missense	probably benign
R9621:Wrn	UTSW	8	33,324,273 (GRCm38)	missense	probably benign	0.01
R9623:Wrn	UTSW	8	33,284,616 (GRCm38)	critical splice donor site	probably null
R9797:Wrn	UTSW	8	33,268,922 (GRCm38)	missense	probably benign	0.02
RF010:Wrn	UTSW	8	33,288,765 (GRCm38)	missense	probably benign	0.13
X0017:Wrn	UTSW	8	33,280,782 (GRCm38)	missense	probably damaging	1.00
Z1176:Wrn	UTSW	8	33,334,209 (GRCm38)	missense	probably damaging	0.98

Posted On

2013-12-09