Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01599:Tmem132c'

92078

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132c

Ensembl Gene

ENSMUSG00000034324

Gene Name

transmembrane protein 132C

Synonyms

2810482M11Rik, 4632425D07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL01599

Quality Score

Status

Chromosome

Chromosomal Location

127241808-127565793 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 127359552 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113090 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000119026]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000119026

SMART Domains

Protein: ENSMUSP00000113090
Gene: ENSMUSG00000034324

Domain	Start	End	E-Value	Type
low complexity region	14	21	N/A	INTRINSIC
Pfam:TMEM132D_N	58	187	1.2e-54	PFAM
Pfam:TMEM132	444	787	4.5e-143	PFAM
Pfam:TMEM132D_C	892	980	2.4e-39	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr3	T	C	1: 90,214,134	V105A	probably benign	Het
Acr	T	C	15: 89,568,414	V18A	probably benign	Het
Adgra2	G	A	8: 27,118,733	A540T	possibly damaging	Het
Aldh16a1	A	G	7: 45,142,093	F753L	probably damaging	Het
Ankfy1	T	A	11: 72,738,365	Y338N	probably benign	Het
Aox3	C	T	1: 58,169,794	R829C	probably damaging	Het
Arhgef11	T	C	3: 87,737,046	S1535P	probably benign	Het
C4b	A	G	17: 34,743,019		probably benign	Het
Ccdc157	A	G	11: 4,148,781	C242R	probably damaging	Het
Cep135	T	A	5: 76,593,347	M90K	possibly damaging	Het
Cfap36	A	T	11: 29,244,057		probably null	Het
Chl1	A	G	6: 103,708,484	T829A	probably benign	Het
Copb2	T	C	9: 98,581,150	S473P	probably damaging	Het
Cpb1	C	T	3: 20,251,954		probably null	Het
Cpsf1	A	G	15: 76,596,541	L1295P	probably damaging	Het
Dmp1	C	T	5: 104,212,462	Q335*	probably null	Het
Dyrk1a	T	A	16: 94,691,884	S621T	possibly damaging	Het
Exoc5	T	A	14: 49,034,964	Q331L	probably benign	Het
Fmnl1	G	A	11: 103,186,656	V287M	probably damaging	Het
Fras1	T	C	5: 96,709,891	S2015P	possibly damaging	Het
Gm7052	T	C	17: 22,040,004		probably benign	Het
Gprc5c	A	G	11: 114,864,252	I252V	probably benign	Het
Ints3	C	T	3: 90,394,322		probably null	Het
L1td1	A	G	4: 98,737,344	D592G	probably damaging	Het
Lamb3	A	G	1: 193,343,412	M1137V	probably benign	Het
Leng8	C	A	7: 4,145,482	A751E	probably benign	Het
Lfng	T	C	5: 140,612,535	V204A	probably damaging	Het
Lsm14b	A	G	2: 180,032,603	D233G	probably damaging	Het
Map4	C	T	9: 110,034,768	P354S	probably benign	Het
Mapt	G	A	11: 104,294,915	V53M	probably damaging	Het
Mier1	T	G	4: 103,155,541	S377A	possibly damaging	Het
Neurog1	T	C	13: 56,251,847	D29G	probably damaging	Het
Npr3	G	A	15: 11,895,789	A257V	probably damaging	Het
Nup188	T	C	2: 30,327,525	V824A	possibly damaging	Het
Olfm4	T	C	14: 80,021,310	S333P	probably damaging	Het
Olfr460	A	C	6: 40,572,252	I289L	probably damaging	Het
Olfr849	T	G	9: 19,441,815	F301V	probably benign	Het
Pbxip1	C	A	3: 89,443,590		probably benign	Het
Pde9a	G	T	17: 31,414,150	C38F	probably damaging	Het
Plb1	A	T	5: 32,342,544		probably benign	Het
Plcz1	T	C	6: 140,002,256		probably benign	Het
Plxnb1	T	C	9: 109,110,604	V1447A	probably damaging	Het
Pnldc1	A	T	17: 12,906,528	M73K	probably benign	Het
Psg20	C	T	7: 18,681,038	V311M	possibly damaging	Het
Psmd2	G	T	16: 20,659,405		probably null	Het
Rabgap1	T	C	2: 37,556,269	V859A	probably damaging	Het
Rad51b	T	A	12: 79,327,228	S194T	probably benign	Het
Rb1cc1	C	T	1: 6,248,771	Q788*	probably null	Het
Ror2	C	T	13: 53,111,617	G468R	probably damaging	Het
Slamf7	A	G	1: 171,641,186	I46T	possibly damaging	Het
Stab2	A	G	10: 86,922,895	S1060P	probably damaging	Het
Syndig1	T	A	2: 150,003,283	V242E	probably damaging	Het
Tgfbr3	G	A	5: 107,118,451	T801M	probably damaging	Het
Trav21-dv12	T	C	14: 53,876,731	Y103H	probably damaging	Het
Ubr3	T	C	2: 69,938,178	V443A	probably damaging	Het
Uhrf2	G	T	19: 30,092,120	C749F	probably damaging	Het
Ulk2	G	T	11: 61,791,436	S751*	probably null	Het
Wrn	G	A	8: 33,241,011	P1098S	possibly damaging	Het
Xrcc5	T	C	1: 72,346,349	V533A	possibly damaging	Het
Zc3h13	T	C	14: 75,309,723	S223P	probably damaging	Het
Zcchc11	T	C	4: 108,513,399	S871P	possibly damaging	Het

Other mutations in Tmem132c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00869:Tmem132c	APN	5	127563242	missense	possibly damaging	0.95
IGL00985:Tmem132c	APN	5	127504866	missense	probably damaging	0.99
IGL01750:Tmem132c	APN	5	127462959	missense	possibly damaging	0.91
IGL01893:Tmem132c	APN	5	127463029	missense	possibly damaging	0.51
IGL02143:Tmem132c	APN	5	127563402	missense	probably benign	0.03
IGL02164:Tmem132c	APN	5	127536377	missense	probably damaging	1.00
IGL02252:Tmem132c	APN	5	127462927	missense	possibly damaging	0.91
IGL02527:Tmem132c	APN	5	127359611	missense	possibly damaging	0.95
IGL02584:Tmem132c	APN	5	127504999	missense	probably damaging	1.00
IGL02878:Tmem132c	APN	5	127563090	missense	probably damaging	0.99
IGL03065:Tmem132c	APN	5	127563624	missense	probably damaging	1.00
IGL03120:Tmem132c	APN	5	127563384	missense	probably benign	0.06
IGL03380:Tmem132c	APN	5	127536442	missense	probably benign	0.00
IGL03387:Tmem132c	APN	5	127563720	missense	probably benign	0.00
R0106:Tmem132c	UTSW	5	127554669	missense	possibly damaging	0.94
R0106:Tmem132c	UTSW	5	127554669	missense	possibly damaging	0.94
R0415:Tmem132c	UTSW	5	127563705	missense	probably damaging	1.00
R0607:Tmem132c	UTSW	5	127563553	nonsense	probably null
R1413:Tmem132c	UTSW	5	127563567	missense	probably damaging	1.00
R1531:Tmem132c	UTSW	5	127359891	missense	probably damaging	1.00
R1648:Tmem132c	UTSW	5	127463056	splice site	probably benign
R2148:Tmem132c	UTSW	5	127462962	missense	probably damaging	1.00
R2149:Tmem132c	UTSW	5	127462962	missense	probably damaging	1.00
R2259:Tmem132c	UTSW	5	127504924	missense	probably benign	0.01
R3853:Tmem132c	UTSW	5	127359869	missense	probably benign	0.00
R4204:Tmem132c	UTSW	5	127563765	missense	possibly damaging	0.73
R4543:Tmem132c	UTSW	5	127504977	missense	probably benign	0.00
R4701:Tmem132c	UTSW	5	127564496	unclassified	probably benign
R5017:Tmem132c	UTSW	5	127563350	missense	probably benign	0.13
R5037:Tmem132c	UTSW	5	127553135	missense	probably benign	0.42
R5327:Tmem132c	UTSW	5	127563752	missense	possibly damaging	0.50
R5423:Tmem132c	UTSW	5	127563843	missense	probably benign	0.02
R5548:Tmem132c	UTSW	5	127551523	nonsense	probably null
R6425:Tmem132c	UTSW	5	127553265	missense	possibly damaging	0.95
R6717:Tmem132c	UTSW	5	127564029	missense	possibly damaging	0.93
R6899:Tmem132c	UTSW	5	127551680	missense	probably damaging	1.00
R7007:Tmem132c	UTSW	5	127359615	missense	probably damaging	1.00
R7297:Tmem132c	UTSW	5	127360217	missense	probably benign	0.06
R7326:Tmem132c	UTSW	5	127564059	missense	possibly damaging	0.51
R7386:Tmem132c	UTSW	5	127563926	missense	probably benign	0.16
R7504:Tmem132c	UTSW	5	127554632	missense	probably damaging	1.00
R7640:Tmem132c	UTSW	5	127563006	missense	probably damaging	1.00
R7718:Tmem132c	UTSW	5	127563440	missense	probably benign	0.06
R7762:Tmem132c	UTSW	5	127554696	missense	possibly damaging	0.90
R7818:Tmem132c	UTSW	5	127564088	makesense	probably null
R8117:Tmem132c	UTSW	5	127360112	missense	probably benign	0.22
R8425:Tmem132c	UTSW	5	127564357	missense
R8749:Tmem132c	UTSW	5	127359939	missense	possibly damaging	0.75
R8771:Tmem132c	UTSW	5	127360128	missense	probably benign	0.00
R8798:Tmem132c	UTSW	5	127360153	nonsense	probably null
R9372:Tmem132c	UTSW	5	127563081	missense	probably damaging	1.00
X0067:Tmem132c	UTSW	5	127536407	missense	possibly damaging	0.79
Z1088:Tmem132c	UTSW	5	127504921	missense	probably benign	0.14

Posted On

2013-12-09