Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01611:Tas2r117'

92123

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r117

Ensembl Gene

ENSMUSG00000058349

Gene Name

taste receptor, type 2, member 117

Synonyms

T2R17, mGR17, Tas2r17, mt2r54

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL01611

Quality Score

Status

Chromosome

Chromosomal Location

132779864-132780856 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 132780450 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 196 (V196A)

Ref Sequence

ENSEMBL: ENSMUSP00000069768 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068302]

AlphaFold

Q7M715

Predicted Effect

probably damaging
Transcript: ENSMUST00000068302
AA Change: V196A

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349
AA Change: V196A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	307	1.2e-85	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447C04Rik	A	G	12: 72,954,644 (GRCm39)	L209S	possibly damaging	Het
Abcc2	G	T	19: 43,815,068 (GRCm39)	V1152F	probably damaging	Het
Adam9	C	T	8: 25,457,212 (GRCm39)	V639I	probably benign	Het
Cdc6	A	G	11: 98,805,989 (GRCm39)	I388V	probably benign	Het
Chrm5	C	T	2: 112,310,651 (GRCm39)	W155*	probably null	Het
Chrna9	A	G	5: 66,128,287 (GRCm39)	D161G	probably damaging	Het
Det1	A	G	7: 78,477,702 (GRCm39)	V541A	possibly damaging	Het
Efhc1	G	T	1: 21,060,911 (GRCm39)	*649L	probably null	Het
Ehbp1	C	T	11: 22,122,883 (GRCm39)	V146M	probably damaging	Het
Enam	A	C	5: 88,651,608 (GRCm39)	D1039A	probably damaging	Het
Fam20b	A	T	1: 156,530,035 (GRCm39)	V133E	probably benign	Het
Frem2	T	A	3: 53,563,130 (GRCm39)	Q459L	probably benign	Het
Gapdhs	C	T	7: 30,429,866 (GRCm39)		probably benign	Het
Gm3404	T	A	5: 146,465,157 (GRCm39)	V299D	possibly damaging	Het
Gorasp2	C	A	2: 70,519,604 (GRCm39)	H310N	possibly damaging	Het
Gpr157	T	C	4: 150,186,094 (GRCm39)	S219P	possibly damaging	Het
Gpt2	T	A	8: 86,246,167 (GRCm39)	C375*	probably null	Het
Gtf2h3	T	C	5: 124,733,748 (GRCm39)	S274P	probably damaging	Het
Hmg20b	C	T	10: 81,183,309 (GRCm39)	V83M	probably benign	Het
Igf2r	G	T	17: 12,944,302 (GRCm39)	Y400*	probably null	Het
Ipo9	A	T	1: 135,314,431 (GRCm39)	W942R	possibly damaging	Het
Iqch	T	C	9: 63,403,519 (GRCm39)		probably null	Het
Kcnh3	T	C	15: 99,127,383 (GRCm39)	L393P	probably benign	Het
Kcnk12	T	A	17: 88,104,495 (GRCm39)	I130L	probably benign	Het
Lcorl	T	C	5: 45,904,434 (GRCm39)	T205A	probably damaging	Het
Lpar6	G	T	14: 73,476,878 (GRCm39)	A280S	probably damaging	Het
Mgarp	A	T	3: 51,296,570 (GRCm39)	V152E	probably damaging	Het
Pard3b	A	G	1: 62,677,021 (GRCm39)	D1184G	probably damaging	Het
Pcnt	A	G	10: 76,272,258 (GRCm39)		probably null	Het
Pde6b	A	G	5: 108,551,262 (GRCm39)	N182S	possibly damaging	Het
Pom121	T	C	5: 135,412,526 (GRCm39)	K516E	unknown	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Ptpn18	T	C	1: 34,498,898 (GRCm39)		probably benign	Het
Rapgef5	C	T	12: 117,717,154 (GRCm39)		probably benign	Het
Ryr2	A	G	13: 11,606,202 (GRCm39)	L4460S	possibly damaging	Het
Sema6b	T	C	17: 56,436,969 (GRCm39)		probably null	Het
Serpinb6d	T	A	13: 33,850,375 (GRCm39)	C67*	probably null	Het
Sorbs2	T	G	8: 46,248,381 (GRCm39)	V510G	probably null	Het
Spic	T	A	10: 88,511,864 (GRCm39)	I131F	possibly damaging	Het
Spire2	T	C	8: 124,086,137 (GRCm39)	S290P	probably damaging	Het
Tff1	C	T	17: 31,381,703 (GRCm39)	G58D	probably damaging	Het
Tmprss11g	T	C	5: 86,638,640 (GRCm39)	T283A	probably benign	Het
Toporsl	T	A	4: 52,610,794 (GRCm39)	L229H	probably damaging	Het
Vmn2r80	G	A	10: 79,007,488 (GRCm39)	G488D	probably damaging	Het
Vps54	T	A	11: 21,261,082 (GRCm39)	V583D	probably damaging	Het
Vwa1	T	C	4: 155,855,255 (GRCm39)	E286G	possibly damaging	Het
Vwde	A	T	6: 13,219,977 (GRCm39)	I58N	probably damaging	Het
Zbtb11	T	C	16: 55,800,973 (GRCm39)	V109A	probably damaging	Het
Zfp319	C	T	8: 96,055,540 (GRCm39)	R221Q	probably benign	Het

Other mutations in Tas2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01611:Tas2r117	APN	6	132,780,447 (GRCm39)	missense	probably benign	0.00
IGL02140:Tas2r117	APN	6	132,780,558 (GRCm39)	missense	probably benign	0.15
IGL02154:Tas2r117	APN	6	132,780,678 (GRCm39)	missense	probably benign	0.00
IGL02466:Tas2r117	APN	6	132,779,963 (GRCm39)	missense	probably benign	0.12
IGL02942:Tas2r117	APN	6	132,780,657 (GRCm39)	missense	probably benign	0.00
IGL03328:Tas2r117	APN	6	132,780,041 (GRCm39)	missense	probably benign	0.40
PIT4480001:Tas2r117	UTSW	6	132,780,014 (GRCm39)	missense	possibly damaging	0.91
R0380:Tas2r117	UTSW	6	132,780,551 (GRCm39)	nonsense	probably null
R0456:Tas2r117	UTSW	6	132,780,354 (GRCm39)	missense	probably benign	0.12
R0699:Tas2r117	UTSW	6	132,780,161 (GRCm39)	missense	probably damaging	1.00
R2118:Tas2r117	UTSW	6	132,780,129 (GRCm39)	missense	probably damaging	0.96
R2265:Tas2r117	UTSW	6	132,780,188 (GRCm39)	missense	probably benign	0.06
R4420:Tas2r117	UTSW	6	132,780,312 (GRCm39)	nonsense	probably null
R4861:Tas2r117	UTSW	6	132,780,092 (GRCm39)	missense	probably benign	0.00
R4861:Tas2r117	UTSW	6	132,780,092 (GRCm39)	missense	probably benign	0.00
R5233:Tas2r117	UTSW	6	132,780,585 (GRCm39)	missense	possibly damaging	0.95
R5384:Tas2r117	UTSW	6	132,780,117 (GRCm39)	missense	probably benign	0.04
R6750:Tas2r117	UTSW	6	132,779,817 (GRCm39)	start gained	probably benign
R6852:Tas2r117	UTSW	6	132,779,892 (GRCm39)	missense	probably benign	0.00
R6902:Tas2r117	UTSW	6	132,780,288 (GRCm39)	missense	probably damaging	0.98
R6946:Tas2r117	UTSW	6	132,780,288 (GRCm39)	missense	probably damaging	0.98
R7129:Tas2r117	UTSW	6	132,780,350 (GRCm39)	missense	probably benign	0.01
R7412:Tas2r117	UTSW	6	132,780,192 (GRCm39)	missense	probably damaging	1.00
R7733:Tas2r117	UTSW	6	132,780,138 (GRCm39)	missense	probably benign	0.02
R7768:Tas2r117	UTSW	6	132,780,485 (GRCm39)	missense	probably damaging	1.00
R7953:Tas2r117	UTSW	6	132,780,281 (GRCm39)	missense	probably damaging	1.00
R9629:Tas2r117	UTSW	6	132,780,374 (GRCm39)	missense	probably benign	0.41

Posted On

2013-12-09