Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01613:Cdk10'

92241

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdk10

Ensembl Gene

ENSMUSG00000033862

Gene Name

cyclin-dependent kinase 10

Synonyms

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.251) question?

Stock #

IGL01613

Quality Score

Status

Chromosome

Chromosomal Location

123224842-123232250 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123228387 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 159 (I159T)

Ref Sequence

ENSEMBL: ENSMUSP00000045527 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036880] [ENSMUST00000098327] [ENSMUST00000127664] [ENSMUST00000166768] [ENSMUST00000212193] [ENSMUST00000212361] [ENSMUST00000213005]

Predicted Effect

probably damaging
Transcript: ENSMUST00000036880
AA Change: I159T

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000045527
Gene: ENSMUSG00000033862
AA Change: I159T

Domain	Start	End	E-Value	Type
S_TKc	39	323	1.52e-87	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000098327

SMART Domains

Protein: ENSMUSP00000095932
Gene: ENSMUSG00000033594

Domain	Start	End	E-Value	Type
low complexity region	74	91	N/A	INTRINSIC
low complexity region	209	214	N/A	INTRINSIC
low complexity region	294	308	N/A	INTRINSIC
low complexity region	309	318	N/A	INTRINSIC
low complexity region	340	347	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000127664

SMART Domains

Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

Domain	Start	End	E-Value	Type
Pfam:Glycos_transf_2	104	287	7.4e-31	PFAM
Pfam:Glyco_transf_7C	261	331	4.9e-8	PFAM
RICIN	406	531	9.28e-27	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000166768

SMART Domains

Protein: ENSMUSP00000130306
Gene: ENSMUSG00000033594

Domain	Start	End	E-Value	Type
low complexity region	74	91	N/A	INTRINSIC
low complexity region	209	214	N/A	INTRINSIC
low complexity region	294	308	N/A	INTRINSIC
low complexity region	309	318	N/A	INTRINSIC
low complexity region	340	347	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211845

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211876

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212021

Predicted Effect

probably benign
Transcript: ENSMUST00000212028

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212035

Predicted Effect

probably benign
Transcript: ENSMUST00000212193

Predicted Effect

unknown
Transcript: ENSMUST00000212361
AA Change: S125P

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212497

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212532

Predicted Effect

probably damaging
Transcript: ENSMUST00000213005
AA Change: I88T

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212904

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212784

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212749

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	T	G	5: 125,512,652	M446R	possibly damaging	Het
Abca16	A	G	7: 120,541,277	N1599S	probably benign	Het
Ankib1	G	A	5: 3,713,146	Q528*	probably null	Het
Ano10	A	T	9: 122,259,540	L347M	possibly damaging	Het
Bag6	T	C	17: 35,143,016		probably benign	Het
Bpnt1	T	C	1: 185,353,994	V182A	possibly damaging	Het
Capn13	G	T	17: 73,331,058	T450N	probably benign	Het
Cbr3	A	T	16: 93,683,443	E40V	probably benign	Het
Cela3b	T	C	4: 137,425,071	D65G	possibly damaging	Het
Csf2rb	T	G	15: 78,335,302		probably benign	Het
Cyp2b19	C	T	7: 26,763,461	T256I	possibly damaging	Het
Dpp9	T	C	17: 56,190,713	H687R	probably benign	Het
Elovl1	T	C	4: 118,431,270	V108A	probably benign	Het
Emb	T	A	13: 117,272,078	N318K	probably damaging	Het
Ermp1	A	G	19: 29,639,939	L36P	probably damaging	Het
Esco2	T	G	14: 65,826,595	H380P	possibly damaging	Het
Gm5724	G	T	6: 141,713,214	T552K	possibly damaging	Het
Gm9747	G	A	1: 82,234,088		probably benign	Het
Golga1	A	G	2: 39,020,126	M603T	probably benign	Het
Hsph1	A	G	5: 149,627,278	V411A	probably benign	Het
Igsf21	C	T	4: 140,107,364	G66S	possibly damaging	Het
Ints11	T	C	4: 155,885,198		probably null	Het
Jakmip1	G	T	5: 37,100,768	A253S	probably damaging	Het
Met	A	G	6: 17,540,577	Y834C	probably damaging	Het
Mgl2	A	G	11: 70,134,158	T2A	probably benign	Het
Myh2	G	T	11: 67,197,344	V1929L	probably benign	Het
Myh8	T	C	11: 67,301,710	S1472P	probably benign	Het
Myo1e	T	C	9: 70,341,273		probably benign	Het
Ndufaf7	A	G	17: 78,937,502	I17V	probably benign	Het
Olfr1046	T	G	2: 86,217,161	D183A	probably damaging	Het
Olfr1256	T	C	2: 89,835,808	T46A	probably damaging	Het
Olfr193	A	T	16: 59,109,921	S230T	probably damaging	Het
Olfr804	A	G	10: 129,705,623	I248M	probably benign	Het
Olfr830	T	A	9: 18,875,321		probably benign	Het
Olfr914	A	G	9: 38,606,554	I30V	probably null	Het
Olfr992	C	T	2: 85,400,171	D121N	probably damaging	Het
Ppef2	T	C	5: 92,235,820	E477G	probably benign	Het
Scmh1	T	A	4: 120,529,900		probably benign	Het
Scn1a	C	A	2: 66,285,937	D1473Y	probably damaging	Het
Sdr42e1	C	T	8: 117,662,937	V322I	probably benign	Het
Spta1	G	A	1: 174,208,394	A1089T	probably damaging	Het
Sufu	T	C	19: 46,475,620	Y424H	probably damaging	Het
Tgs1	T	C	4: 3,585,183	F108L	possibly damaging	Het
Ttn	T	C	2: 76,974,964	N177S	probably benign	Het
Tyk2	T	C	9: 21,120,576	D401G	probably damaging	Het
Vav1	T	C	17: 57,307,067	F650L	possibly damaging	Het
Wdr12	T	C	1: 60,080,559	H385R	probably damaging	Het
Xab2	T	C	8: 3,610,880	M745V	probably benign	Het

Other mutations in Cdk10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Cdk10	APN	8	123230324	missense	possibly damaging	0.78
IGL01682:Cdk10	APN	8	123227658	critical splice acceptor site	probably null
IGL02536:Cdk10	APN	8	123227015	missense	possibly damaging	0.64
R0612:Cdk10	UTSW	8	123230680	missense	probably benign	0.16
R1159:Cdk10	UTSW	8	123228323	splice site	probably benign
R2356:Cdk10	UTSW	8	123229169	missense	probably damaging	0.99
R4838:Cdk10	UTSW	8	123230614	missense	probably damaging	1.00
R5453:Cdk10	UTSW	8	123226392	missense	probably benign	0.42
R5517:Cdk10	UTSW	8	123230587	splice site	probably null
R5804:Cdk10	UTSW	8	123228840	splice site	probably null
R6930:Cdk10	UTSW	8	123230608	missense	probably damaging	1.00
R6971:Cdk10	UTSW	8	123227674	missense	probably damaging	1.00
R7910:Cdk10	UTSW	8	123226366	missense	probably damaging	1.00
R8356:Cdk10	UTSW	8	123228357	missense	probably benign	0.00

Posted On

2013-12-09