Incidental Mutation 'IGL01613:Mgl2'
ID 92269
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mgl2
Ensembl Gene ENSMUSG00000040950
Gene Name macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms CD301b
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01613
Quality Score
Chromosome 11
Chromosomal Location 70021155-70028376 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70024984 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 2 (T2A)
Ref Sequence ENSEMBL: ENSMUSP00000131344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041550] [ENSMUST00000108584] [ENSMUST00000165951]
AlphaFold A9XX86
Predicted Effect probably benign
Transcript: ENSMUST00000041550
AA Change: T2A

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000048568
Gene: ENSMUSG00000040950
AA Change: T2A

Pfam:Lectin_N 6 179 4.6e-56 PFAM
CLECT 189 313 2.37e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108584
SMART Domains Protein: ENSMUSP00000104225
Gene: ENSMUSG00000040950

Pfam:Lectin_N 8 173 8.6e-56 PFAM
CLECT 183 355 5.76e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118803
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132645
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147502
Predicted Effect probably benign
Transcript: ENSMUST00000165951
AA Change: T2A

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000131344
Gene: ENSMUSG00000040950
AA Change: T2A

Pfam:Lectin_N 21 133 2.1e-35 PFAM
Pfam:Lectin_N 129 180 5.4e-19 PFAM
CLECT 190 362 5.76e-25 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T G 5: 125,589,716 (GRCm39) M446R possibly damaging Het
Abca16 A G 7: 120,140,500 (GRCm39) N1599S probably benign Het
Ankib1 G A 5: 3,763,146 (GRCm39) Q528* probably null Het
Ano10 A T 9: 122,088,606 (GRCm39) L347M possibly damaging Het
Bag6 T C 17: 35,361,992 (GRCm39) probably benign Het
Bpnt1 T C 1: 185,086,191 (GRCm39) V182A possibly damaging Het
Capn13 G T 17: 73,638,053 (GRCm39) T450N probably benign Het
Cbr3 A T 16: 93,480,331 (GRCm39) E40V probably benign Het
Cdk10 T C 8: 123,955,126 (GRCm39) I159T probably damaging Het
Cela3b T C 4: 137,152,382 (GRCm39) D65G possibly damaging Het
Csf2rb T G 15: 78,219,502 (GRCm39) probably benign Het
Cyp2b19 C T 7: 26,462,886 (GRCm39) T256I possibly damaging Het
Dpp9 T C 17: 56,497,713 (GRCm39) H687R probably benign Het
Elovl1 T C 4: 118,288,467 (GRCm39) V108A probably benign Het
Emb T A 13: 117,408,614 (GRCm39) N318K probably damaging Het
Ermp1 A G 19: 29,617,339 (GRCm39) L36P probably damaging Het
Esco2 T G 14: 66,064,044 (GRCm39) H380P possibly damaging Het
Gm9747 G A 1: 82,211,809 (GRCm39) probably benign Het
Golga1 A G 2: 38,910,138 (GRCm39) M603T probably benign Het
Hsph1 A G 5: 149,550,743 (GRCm39) V411A probably benign Het
Igsf21 C T 4: 139,834,675 (GRCm39) G66S possibly damaging Het
Ints11 T C 4: 155,969,655 (GRCm39) probably null Het
Jakmip1 G T 5: 37,258,112 (GRCm39) A253S probably damaging Het
Met A G 6: 17,540,576 (GRCm39) Y834C probably damaging Het
Myh2 G T 11: 67,088,170 (GRCm39) V1929L probably benign Het
Myh8 T C 11: 67,192,536 (GRCm39) S1472P probably benign Het
Myo1e T C 9: 70,248,555 (GRCm39) probably benign Het
Ndufaf7 A G 17: 79,244,931 (GRCm39) I17V probably benign Het
Or4a47 T C 2: 89,666,152 (GRCm39) T46A probably damaging Het
Or5ak22 C T 2: 85,230,515 (GRCm39) D121N probably damaging Het
Or5h25 A T 16: 58,930,284 (GRCm39) S230T probably damaging Het
Or6c6c A G 10: 129,541,492 (GRCm39) I248M probably benign Het
Or7g18 T A 9: 18,786,617 (GRCm39) probably benign Het
Or8b50 A G 9: 38,517,850 (GRCm39) I30V probably null Het
Or8k1 T G 2: 86,047,505 (GRCm39) D183A probably damaging Het
Ppef2 T C 5: 92,383,679 (GRCm39) E477G probably benign Het
Scmh1 T A 4: 120,387,097 (GRCm39) probably benign Het
Scn1a C A 2: 66,116,281 (GRCm39) D1473Y probably damaging Het
Sdr42e1 C T 8: 118,389,676 (GRCm39) V322I probably benign Het
Slco1a7 G T 6: 141,658,940 (GRCm39) T552K possibly damaging Het
Spta1 G A 1: 174,035,960 (GRCm39) A1089T probably damaging Het
Sufu T C 19: 46,464,059 (GRCm39) Y424H probably damaging Het
Tgs1 T C 4: 3,585,183 (GRCm39) F108L possibly damaging Het
Ttn T C 2: 76,805,308 (GRCm39) N177S probably benign Het
Tyk2 T C 9: 21,031,872 (GRCm39) D401G probably damaging Het
Vav1 T C 17: 57,614,067 (GRCm39) F650L possibly damaging Het
Wdr12 T C 1: 60,119,718 (GRCm39) H385R probably damaging Het
Xab2 T C 8: 3,660,880 (GRCm39) M745V probably benign Het
Other mutations in Mgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Mgl2 APN 11 70,027,932 (GRCm39) missense probably benign 0.33
IGL00757:Mgl2 APN 11 70,025,976 (GRCm39) missense probably damaging 1.00
IGL00838:Mgl2 APN 11 70,025,038 (GRCm39) missense probably benign 0.00
IGL01118:Mgl2 APN 11 70,025,015 (GRCm39) missense probably benign 0.00
IGL02094:Mgl2 APN 11 70,027,923 (GRCm39) missense possibly damaging 0.73
IGL03000:Mgl2 APN 11 70,025,026 (GRCm39) nonsense probably null
R1893:Mgl2 UTSW 11 70,024,993 (GRCm39) splice site probably null
R3767:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3768:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3769:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R5467:Mgl2 UTSW 11 70,025,878 (GRCm39) missense possibly damaging 0.46
R5742:Mgl2 UTSW 11 70,027,510 (GRCm39) missense probably benign 0.00
R6018:Mgl2 UTSW 11 70,027,937 (GRCm39) makesense probably null
R7189:Mgl2 UTSW 11 70,027,869 (GRCm39) missense probably damaging 1.00
R7270:Mgl2 UTSW 11 70,026,506 (GRCm39) missense probably damaging 1.00
R7536:Mgl2 UTSW 11 70,027,833 (GRCm39) missense probably benign 0.02
R8330:Mgl2 UTSW 11 70,026,785 (GRCm39) missense probably benign 0.03
R9174:Mgl2 UTSW 11 70,026,606 (GRCm39) missense probably benign 0.00
Posted On 2013-12-09