Incidental Mutation 'IGL01607:Stk38l'
ID92310
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk38l
Ensembl Gene ENSMUSG00000001630
Gene Nameserine/threonine kinase 38 like
Synonyms4930473A22Rik, Ndr2
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.566) question?
Stock #IGL01607
Quality Score
Status
Chromosome6
Chromosomal Location146724995-146778812 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 146772227 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001675] [ENSMUST00000111644]
Predicted Effect probably benign
Transcript: ENSMUST00000001675
SMART Domains Protein: ENSMUSP00000001675
Gene: ENSMUSG00000001630

DomainStartEndE-ValueType
S_TKc 90 383 5.62e-100 SMART
S_TK_X 384 445 2.88e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111644
SMART Domains Protein: ENSMUSP00000107271
Gene: ENSMUSG00000001630

DomainStartEndE-ValueType
S_TKc 90 383 5.62e-100 SMART
S_TK_X 384 452 3.66e-1 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous gene-trapped mice exhibit premature dendritic branching of CA3 pyramidal neurons. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A G 11: 54,352,997 K556E possibly damaging Het
Adgre4 A C 17: 55,794,748 probably benign Het
Ajap1 C T 4: 153,432,279 G202S probably damaging Het
Catsperb G T 12: 101,480,726 probably benign Het
Ccdc178 T A 18: 22,067,721 D393V probably benign Het
Cfap74 A G 4: 155,418,986 T95A possibly damaging Het
Dis3l2 A G 1: 86,745,487 T67A probably benign Het
Dnaja3 T C 16: 4,693,395 F205L probably damaging Het
Dsc1 C T 18: 20,089,663 C584Y probably damaging Het
Duox2 C A 2: 122,292,319 V545L probably benign Het
Etaa1 A G 11: 17,953,637 L53P probably benign Het
Gm14184 C T 11: 99,699,664 C4Y unknown Het
Inpp4b C T 8: 82,010,663 A563V probably benign Het
Kcnc3 A G 7: 44,591,304 D140G probably damaging Het
Ly6a A T 15: 74,995,413 M85K probably benign Het
Map4k2 C T 19: 6,345,593 probably null Het
Mttp T C 3: 138,104,698 Y652C probably damaging Het
Neu1 A T 17: 34,934,716 N372I probably benign Het
Nuak2 G A 1: 132,328,140 V184I probably damaging Het
Phf11a T C 14: 59,287,501 I85V probably damaging Het
Polr2e C A 10: 80,039,633 D3Y probably damaging Het
Ralb A G 1: 119,483,549 V20A probably damaging Het
Rln1 A T 19: 29,331,860 V173D probably benign Het
Tjp1 G T 7: 65,336,178 D288E possibly damaging Het
Trpm3 A G 19: 22,987,127 I1319V probably benign Het
Zic2 T G 14: 122,478,882 probably benign Het
Other mutations in Stk38l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Stk38l APN 6 146758473 start codon destroyed probably null 0.05
IGL00976:Stk38l APN 6 146775402 missense probably benign 0.37
IGL01607:Stk38l APN 6 146771654 missense probably damaging 0.99
IGL02552:Stk38l APN 6 146767533 missense probably damaging 1.00
IGL02582:Stk38l APN 6 146766823 critical splice donor site probably null
IGL03036:Stk38l APN 6 146768874 missense probably damaging 1.00
R0445:Stk38l UTSW 6 146775686 missense probably benign
R1518:Stk38l UTSW 6 146771631 missense probably benign 0.09
R2117:Stk38l UTSW 6 146768846 missense probably damaging 1.00
R5297:Stk38l UTSW 6 146775655 nonsense probably null
R5602:Stk38l UTSW 6 146758500 missense probably benign 0.39
R5652:Stk38l UTSW 6 146773328 missense possibly damaging 0.91
R6830:Stk38l UTSW 6 146766771 missense possibly damaging 0.88
R7572:Stk38l UTSW 6 146775654 missense probably damaging 1.00
R8028:Stk38l UTSW 6 146773383 missense probably damaging 1.00
R8120:Stk38l UTSW 6 146758601 missense probably benign
R8142:Stk38l UTSW 6 146758572 missense probably benign 0.33
Posted On2013-12-09