Incidental Mutation 'IGL01614:Or1o1'
ID 92312
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1o1
Ensembl Gene ENSMUSG00000063188
Gene Name olfactory receptor family 1 subfamily O member 1
Synonyms MOR156-3, GA_x6K02T2PSCP-1867165-1868094, Olfr107
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL01614
Quality Score
Status
Chromosome 17
Chromosomal Location 37716368-37717400 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37716529 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 30 (C30Y)
Ref Sequence ENSEMBL: ENSMUSP00000148879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077008] [ENSMUST00000215894] [ENSMUST00000215947] [ENSMUST00000215974] [ENSMUST00000216844]
AlphaFold Q7TRK4
Predicted Effect probably benign
Transcript: ENSMUST00000077008
AA Change: C30Y

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000076267
Gene: ENSMUSG00000063188
AA Change: C30Y

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.3e-5 PFAM
Pfam:7tm_1 38 287 3.7e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174238
Predicted Effect probably benign
Transcript: ENSMUST00000215894
AA Change: C30Y

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000215947
AA Change: C30Y

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000215974
AA Change: C30Y

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000216844
AA Change: C30Y

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf5 T A 17: 43,735,362 (GRCm39) S143T possibly damaging Het
Arhgap32 G T 9: 32,171,801 (GRCm39) S1527I probably damaging Het
Atp8a2 A G 14: 60,282,437 (GRCm39) V128A probably damaging Het
Bpi T C 2: 158,113,866 (GRCm39) F255L probably damaging Het
Clptm1 A T 7: 19,371,625 (GRCm39) D269E probably benign Het
Cyria T C 12: 12,411,574 (GRCm39) probably null Het
E2f7 T C 10: 110,595,839 (GRCm39) V63A probably damaging Het
Eif4e1b T A 13: 54,934,729 (GRCm39) I184N probably damaging Het
Gal3st1 T A 11: 3,948,996 (GRCm39) L401Q probably damaging Het
Gm7808 G A 9: 19,839,442 (GRCm39) probably benign Het
Hdac5 G A 11: 102,090,854 (GRCm39) T741I probably benign Het
Ipo5 A G 14: 121,172,507 (GRCm39) T522A probably benign Het
Lama5 A C 2: 179,822,657 (GRCm39) F2832V probably damaging Het
Ltk A C 2: 119,583,968 (GRCm39) L230R probably damaging Het
Mettl14 A T 3: 123,167,609 (GRCm39) probably benign Het
Myom1 T C 17: 71,433,173 (GRCm39) F1507L possibly damaging Het
Nsd3 T A 8: 26,156,095 (GRCm39) I554K possibly damaging Het
Or1j12 T G 2: 36,342,636 (GRCm39) I13S probably benign Het
Or51a43 C T 7: 103,717,576 (GRCm39) V221I probably benign Het
Or8u9 A T 2: 86,001,741 (GRCm39) I140N possibly damaging Het
Prr14 T A 7: 127,074,305 (GRCm39) L279H probably damaging Het
Rbm25 G T 12: 83,706,341 (GRCm39) D229Y probably damaging Het
Sdk2 T C 11: 113,684,684 (GRCm39) K1926E probably damaging Het
Slc25a23 C T 17: 57,352,579 (GRCm39) R435Q probably null Het
Srebf2 A G 15: 82,063,054 (GRCm39) N457S probably benign Het
Stac2 T C 11: 97,943,774 (GRCm39) D12G probably benign Het
Tal1 A C 4: 114,920,325 (GRCm39) probably null Het
Usp25 G A 16: 76,874,005 (GRCm39) R527Q probably damaging Het
Other mutations in Or1o1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Or1o1 APN 17 37,717,031 (GRCm39) missense probably benign 0.00
IGL02390:Or1o1 APN 17 37,716,986 (GRCm39) missense probably benign 0.04
R1051:Or1o1 UTSW 17 37,717,341 (GRCm39) missense possibly damaging 0.74
R4767:Or1o1 UTSW 17 37,717,091 (GRCm39) nonsense probably null
R4849:Or1o1 UTSW 17 37,716,589 (GRCm39) missense probably benign 0.16
R6182:Or1o1 UTSW 17 37,716,883 (GRCm39) missense possibly damaging 0.65
R6550:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6551:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6552:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6555:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6584:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6586:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6588:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6688:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6758:Or1o1 UTSW 17 37,716,586 (GRCm39) missense probably damaging 0.97
R7024:Or1o1 UTSW 17 37,717,095 (GRCm39) missense probably benign 0.04
R7083:Or1o1 UTSW 17 37,717,063 (GRCm39) missense probably benign 0.00
R8350:Or1o1 UTSW 17 37,717,260 (GRCm39) missense probably benign 0.00
Posted On 2013-12-09